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All Journal Jurnal EduHealth International Journal of Health and Pharmaceutical (IJHP)
Marthin Simbolon, Boyke
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Health Professions Nursing Public Health Veterinary

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Comparison of the Effectiveness of Dermapen Using Trambosit Plasma and Scar Serum Dermapen Actions on Scar Acne Areas on the Skin Surface of Wistar Female Rats (Rattus Norvegicus) Riza Al Djoefri, Mohamad; Wienaldi, Wienaldi; Chailur, Muhammad; Marthin Simbolon, Boyke
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

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Abstract

This study aimed to analyze and compare the effectiveness of the action of dermapen using plasma from platelets with the movement of dermapen using scar serum on pockmarked areas on the skin surface of female Wistar rats (Rattus norvegicus). The results of wound observations based on the period (days) with an average healing time of 10.4 days and 12 days needed by each mouse to close the wound in the PRP dermapen group were faster than the serum scar group. This can be explained by the PRP content containing growth factors important for wound healing and tissue regeneration, thus accelerating healing. Meanwhile, scar serum contains concentrates that are useful for nourishing and moisturizing the skin, which can easily penetrate the deepest layers of the skin, thereby accelerating skin regeneration. Further microscopic studies, such as histopathological studies, are needed to examine the number of fibroblasts.
The Effect of Red Ginger Extract (Zingiber officinale Roscoe, Zingiberaceae) on Analgesia in Male White Rats (Rattus norvegicus) Wistar Strain with Head Injuries Marthin Simbolon, Boyke; Hasanah SB, Nurul; Br Tarigan, Elviyanti
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.498

Abstract

Head injury represents a significant clinical challenge requiring effective pain management strategies. This study examined the analgesic effects of red ginger extract on head injury in male Wistar rats. The research employed an experimental post-test only control group design with five treatment groups (n = 25 subjects; n = 5 per group). Group K1 received piroxicam (40 mg per 200 g body weight); K2 served as untreated control; groups K3, K4, K5 received red ginger extract at 50, 100, and 150 micrograms per kilogram of body weight per day respectively. Behavioral pain assessment was conducted on days 8 and 21 post-injury using standardized ethological procedures. Statistical analysis utilized Kruskal-Wallis test with post-hoc Mann-Whitney U comparisons. Results demonstrated that K4 (100 μg/kg/day) achieved the lowest mean rank (8.00), indicating superior analgesic efficacy compared to other groups. K4 exhibited comparable effectiveness to piroxicam (K1, mean rank 10.00) and superior outcomes to untreated controls (K2, mean rank 21.60). Selective COX-2 inhibition and inflammatory cytokine reduction mediated these effects. The optimal dose of red ginger extract (100 μg/kg/day) provides significant neuroprotection and may serve as an alternative pain management approach in developing healthcare contexts.
Co-Authors Br Tarigan, Elviyanti Chailur, Muhammad Hasanah SB, Nurul Riza Al Djoefri, Mohamad Wienaldi, Wienaldi