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All Journal Syntax Literate: Jurnal Ilmiah Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat International Journal of Islamic Education, Research and Multiculturalism (IJIERM) International Journal of Health and Pharmaceutical (IJHP) Ranah Research : Journal of Multidisciplinary Research and Development
Tarigan, Elviyanti
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ROLE OF CURCUMA ZEDOARIA EXTRACT ON PLACENTAL GROWTH FACTOR (PLGF) IN DIABETIC RETINOPATHY WHITE WISTAR RATS Ong, Gabriella Fransisca; Rusip, Gusbakti; Chiuman, Linda; Sulistijanto, Eddy; Tarigan, Elviyanti
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.400

Abstract

Diabetic retinopathy is damage to retinal capillaries in diabetics that can cause visual impairment, ranging from mild to permanent blindness. This study aims to analyze the effect of Curcuma zedoaria (temu putih) extract on placental growth factor (PLGF) levels in white Wistar rats with diabetic retinopathy. The research design used post-test only control group, involving six groups of wistar rats with five heads each. Data were analyzed using Oneway ANOVA and t-test. The results showed that the administration of Curcuma zedoaria extract at a dose of 500 mg/kgBB had the greatest effect on reducing PLGF in diabetic retinopathy rats. For reducing blood sugar levels (KGD), a dose of 7500 mg/kgBB proved to be the most effective. However, no significant relationship was found between PLGF levels and retinal histopathology results. Most of the rats had a retinal score of 0, which means no inflammatory cells were found in the retinal layer (0 cells/visual field). There were rats with a retinal score of 1, namely rats that received doses of 250 mg/kgBB and 500 mg/kgBB. In this score, inflammation was found in the outer plexiform layer (OPL). In addition, there were rats with a retinal score of 2 at a dose of 250 mg/kgBB, which also showed the distribution of inflammation in the OPL layer. In this study, Curcuma zedoaria extract can reduce PLGF and KGD in Wistar rats with diabetic retinopathy, although its effect on improving retinal histopathology is still limited.
PENGARUH KRIM EKSTRAK KULIT KAYU MANIS (CINNAMOMUM BURMANNII) TERHADAP PERTUMBUHAN RAMBUT DAN PENYEMBUHAN LUKA PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG MENGALAMI LUKA Safuranti, Aristya Maulida; Sopacua, Erwin; Tarigan, Elviyanti Br
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.41181

Abstract

Penelitian ini dilakukan untuk menguji dan menganalisis efektivitas pemberian krim ekstrak kulit kayu manis (Cinnamomum burmannii) terhadap pertumbuhan rambut dan penyembuhan luka pada tikus putih (Rattus norvegicus) jantan galur wistar yang mengalami luka dermapen. Penelitian yang digunakan pada penelitian ini yaitu kuantitatif eksperimental dengan menggunakan desain true experiment atau eksperimental laboratorium. Penelitian eksperimen dilaksanakan dengan mengontrol semua variabel luar yang dapat mempengaruhi kegiatan eksperimen. Penelitian ini menggunakan post-test only control group design untuk mengetahui dan menganalisis efek pemberian ekstrak kulit kayu manis dalam mempercepat penyembuhan luka dan pertumbuhan rambut pada tikus putih (Rattus norvegicus) galur wistar yang mengalami luka dermapen. Hasil uji fitokimia menunjukkan bahwa krim ekstrak kulit kayu manis mengandung metabolit sekunder berupa flavonoid, saponin, tannin, alkaloid, dan triterpenoid. Senyawa-senyawa ini yang membantu penyembuhan luka bekas dermapen serta merangsang pertumbuhan rambut. Pemberian krim ekstrak kulit kayu manis mempengaruhi pertumbuhan rambut. Berdasarkan perbedaan rata-rata panjang rambut peneliti menyimpulkan bahwa kelompok dengan pertumbuhan rambut paling besar ada pada kelompok perlakuan 3 yang diberi krim ekstrak kulit kayu manis dengan konsentrasi 7%. Sedangkan kelompok dengan pertumbuhan rambut paling sedikit yaitu pada kelompok kontrol yang hanya diberi krim basis. Pemberian krim ekstrak kulit kayu manis dengan konsentrasi 2%, 5%, dan 7% berpengaruh terhadap proses penyembuhan luka bekas dermapen pada tikus putih (Rattus norvegicus) galur wistar. Kelompok perlakuan mengalami penyembuhan total, sedangkan kelompok kontrol yang diberi krim basis tidak.
The Effect of Red Ginger Extract (Zingiber officinale Roscoe, Zingiberaceae) on Analgesia in Male White Rats (Rattus norvegicus) Wistar Strain with Head Injuries Marthin Simbolon, Boyke; Hasanah SB, Nurul; Br Tarigan, Elviyanti
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025 ( Indonesia - Thailand)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.498

Abstract

Head injury represents a significant clinical challenge requiring effective pain management strategies. This study examined the analgesic effects of red ginger extract on head injury in male Wistar rats. The research employed an experimental post-test only control group design with five treatment groups (n = 25 subjects; n = 5 per group). Group K1 received piroxicam (40 mg per 200 g body weight); K2 served as untreated control; groups K3, K4, K5 received red ginger extract at 50, 100, and 150 micrograms per kilogram of body weight per day respectively. Behavioral pain assessment was conducted on days 8 and 21 post-injury using standardized ethological procedures. Statistical analysis utilized Kruskal-Wallis test with post-hoc Mann-Whitney U comparisons. Results demonstrated that K4 (100 μg/kg/day) achieved the lowest mean rank (8.00), indicating superior analgesic efficacy compared to other groups. K4 exhibited comparable effectiveness to piroxicam (K1, mean rank 10.00) and superior outcomes to untreated controls (K2, mean rank 21.60). Selective COX-2 inhibition and inflammatory cytokine reduction mediated these effects. The optimal dose of red ginger extract (100 μg/kg/day) provides significant neuroprotection and may serve as an alternative pain management approach in developing healthcare contexts.
Efek Pemberian Ekstrak Daun Lidah Buaya (Aloe Vera) Terhadap Penyembuhan Luka Bakar Tikus Putih Jantan (Rattus Novergicus) Galur Wistar Simbolon, Boyke Marthin; Hutasoit, Maria Angelina Br; Tarigan , Elviyanti Br
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v11i1.63668

Abstract

Burn injuries are a major cause of morbidity and mortality worldwide, accounting for approximately 180,000 deaths annually. Conventional treatments for burns often cause side effects such as allergic reactions and antibiotic resistance. Aloe vera has been traditionally used as a natural remedy for burns due to its bioactive compounds. This study aims to investigate the effect of aloe vera leaf extract administration on burn wound healing in male Wistar rats (Rattus norvegicus). This experimental research employs a post-test only control group design with 12 rats divided into four groups: negative control, positive control (silver sulfadiazine), and two treatment groups receiving different doses of aloe vera extract. Second-degree burns were induced using a heated iron plate. Parameters observed include wound diameter, healing time, and histopathological analysis of skin tissue. Aloe vera leaf extract contains bioactive compounds such as vitamins A, C, E, flavonoids, saponins, and tannins that play roles in wound healing through anti-inflammatory, antibacterial activities, and collagen synthesis stimulation. This research is expected to provide scientific evidence regarding the effectiveness of aloe vera as a safe, affordable, and accessible natural treatment alternative for burns in the community.
Hubungan Kepatuhan Minum Obat Antiretroviral dengan Kadar Viral Load pada Pasien HIV/AIDS dengan Koinfeksi Sifilis di RS H. Adam Malik Medan Sukma, Triza Via; Br Tarigan, Elviyanti; Simbolon, Boyke Marthin; Br Ginting, Masita Unjuk; Sitompul, Christian Michael Oloan
Ranah Research : Journal of Multidisciplinary Research and Development Vol. 8 No. 2 (2026): Ranah Research : Journal Of Multidisciplinary Research and Development
Publisher : Dinasti Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/rrj.v8i2.1999

Abstract

The Human Immunodeficiency Virus (HIV) is a virus that targets and attacks the human immune system. Acquired immunodeficiency syndrome (AIDS) is an immunosuppressive condition (syndrome) closely associated with various opportunistic infections, secondary neoplasms, and certain neurological manifestations resulting from HIV infection. Adherence to antiretroviral therapy is a key factor in achieving optimal viral load suppression. Viral load testing is one indicator of the success of ARV treatment. The higher the viral load in the blood, the faster HIV disease progresses. Objective: To determine the relationship between adherence to antiretroviral medication and viral load levels in HIV/AIDS patients with syphilis co-infection at H. Adam Malik General Hospital. Methods: This study used an analytical observational research design with purposive sampling techniques, namely measuring antiretroviral medication adherence and viral load levels in HIV/AIDS patients with syphilis co-infection. Results: Of the 100 study subjects, the majority were male (82%) with the largest age group being 25-35 years (48%). The results of the analysis showed a highly significant relationship between the MMAS-8 compliance level and viral load status (χ² = 31.248; df = 2; p = 0.001). There was a clear pattern showing that the higher the level of adherence, the greater the proportion of patients who achieved viral suppression. Only 39% of patients achieved high adherence (score of 8), and there was a dramatic difference in viral suppression between low adherence (14.8%), moderate adherence (55.9%), and high adherence (76.9%).
Co-Authors Br Ginting, Masita Unjuk Chiuman, Linda Gusbakti Rusip Hasanah SB, Nurul Hutasoit, Maria Angelina Br Marthin Simbolon, Boyke Ong, Gabriella Fransisca Safuranti, Aristya Maulida Simbolon, Boyke Marthin Sitompul, Christian Michael Oloan Sopacua, Erwin Sukma, Triza Via Sulistijanto, Eddy