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All Journal AL KAUNIYAH Bioeksperimen: Jurnal Penelitian Biologi
Petrovsky, Ivan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Materials Science & Nanotechnology

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In Silico Insights Into Bioactive Compounds of Wild Sumatran Turmeric (Curcuma sumatrana, Zingiberaceae) as Potent Antioxidant Candidates Petrovsky, Ivan; Santoso, Putra; Fadil, Muhammad Syukri
Al-Kauniyah: Jurnal Biologi Vol. 19 No. 1 (2026): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v19i1.46136

Abstract

Oxidative stress, characterized by an imbalance between reactive oxygen species and antioxidant defenses, contributes to various diseases. Natural products, particularly plant-derived compounds, offer promising therapeutic avenues due to their antioxidant potential. This study investigates the antioxidant properties of wild Sumatran turmeric (Curcuma sumatrana), an endemic Zingiberaceae species from Sumatra, through in silico computational analyses of its rhizome’s bioactive compounds. Twenty-two compounds were evaluated for drug-likeness using Lipinski’s Rule of Five, revealing 21 compounds (95%) as orally bioavailable. Predictive bioactivity via PASS Online identified six compounds with moderate antioxidant activity (Pa >0.3). Molecular docking against antioxidant enzymes (GPx, SOD, CAT) and the Keap1-Nrf2 complex demonstrated significant binding affinities. Notably, 9,10-Epoxy-12-octadecenoate exhibited superior binding to SOD (-5.75 kcal/mol), GPx (-6.42 kcal/mol), and Keap1-Nrf2 (-8.39 kcal/mol), outperforming native ligands. Abietic acid and N-Octylgallate also showed strong interactions with Keap1-Nrf2, suggesting activation of antioxidant response pathways. The results highlight C. sumatrana’s potential to modulate enzymatic antioxidants and Nrf2 signalling. The findings underscore the species’ role as a source of bioactive compounds with drug-like properties, advocating further exploration of its phytochemicals for mitigating oxidative stress-related pathologies while highlighting C. sumatrana as a viable candidate for developing natural therapeutics targeting redox imbalance.
Potential of Bioactive Compounds in Hepatotoxicity Using Primary Cell Culture Method: A Systematic Review Illahi, Angga Illahi Kurnia; Raihan, Afdhal; Petrovsky, Ivan; Maliza, Rita
Bioeksperimen: Jurnal Penelitian Biologi Vol 10, No 1: March 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v10i1.23548

Abstract

Hepatotoxicity is a condition characterized by liver cell damage caused by toxic chemicals. This article aims to explore the effects of compounds that contribute to mitigating hepatotoxicity, focusing on in vitro studies, particularly primary cell culture. In this systematic review, we conducted searches in the PubMed, Science Direct, and Google Scholar databases to find articles published between 2008 and 2022. Several active compounds were identified, including N-Benzylpiperazine (BZP), 1-(3-trifluoromethylphenyl) piperazine (TFMPP), antimycin A, coenzyme Q (CoQ) substrates, the antioxidant Vitamin C, L-glutamine (Gln), Nimesulide, Luteolin, glutathione, angelica sinensis polysaccharide (ASP) from Angelica sinensis, ammonium glycyrrhizin (CAG) from Glycyrrhiza glabra, L-arginine, silymarin from Silybum marianum, and glucurolactone (GA). However, only six compounds were shown to have remedial and treatment effects on hepatotoxicity and utilized primary cell culture with MTT Assay. These six compounds are Luteolin, Glutathione (GSH), Angelica sinensis polysaccharide (ASP) from Angelica sinensis, Ammonium glycyrrhizin (CAG) from Glycyrrhiza glabra, Antimycin A (AA), and Glutamine (Gln). The mechanism of action of these compounds involves preventing further damage to liver cells and repairing cells that have already been damaged. In summary, these compounds play a significant role in addressing hepatotoxicity caused by toxic substances and drugs.
Co-Authors Fadil, Muhammad Syukri Illahi, Angga Illahi Kurnia Maliza, Rita Putra Santoso Raihan, Afdhal