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All Journal AL KAUNIYAH Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks
Fadil, Muhammad Syukri
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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In Silico Insights Into Bioactive Compounds of Wild Sumatran Turmeric (Curcuma sumatrana, Zingiberaceae) as Potent Antioxidant Candidates Petrovsky, Ivan; Santoso, Putra; Fadil, Muhammad Syukri
Al-Kauniyah: Jurnal Biologi Vol. 19 No. 1 (2026): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v19i1.46136

Abstract

Oxidative stress, characterized by an imbalance between reactive oxygen species and antioxidant defenses, contributes to various diseases. Natural products, particularly plant-derived compounds, offer promising therapeutic avenues due to their antioxidant potential. This study investigates the antioxidant properties of wild Sumatran turmeric (Curcuma sumatrana), an endemic Zingiberaceae species from Sumatra, through in silico computational analyses of its rhizome’s bioactive compounds. Twenty-two compounds were evaluated for drug-likeness using Lipinski’s Rule of Five, revealing 21 compounds (95%) as orally bioavailable. Predictive bioactivity via PASS Online identified six compounds with moderate antioxidant activity (Pa >0.3). Molecular docking against antioxidant enzymes (GPx, SOD, CAT) and the Keap1-Nrf2 complex demonstrated significant binding affinities. Notably, 9,10-Epoxy-12-octadecenoate exhibited superior binding to SOD (-5.75 kcal/mol), GPx (-6.42 kcal/mol), and Keap1-Nrf2 (-8.39 kcal/mol), outperforming native ligands. Abietic acid and N-Octylgallate also showed strong interactions with Keap1-Nrf2, suggesting activation of antioxidant response pathways. The results highlight C. sumatrana’s potential to modulate enzymatic antioxidants and Nrf2 signalling. The findings underscore the species’ role as a source of bioactive compounds with drug-like properties, advocating further exploration of its phytochemicals for mitigating oxidative stress-related pathologies while highlighting C. sumatrana as a viable candidate for developing natural therapeutics targeting redox imbalance.
Community Empowerment in Rural Areas Through the Cultivation and Production of Traditional Medicines Based on Medicinal Plants in Batu Tanjung Village, Talawi, Sawahlunto City Dillasamola, Dwisari; Putri, Biomechy Oktomalio; Noverial; Fadil, Muhammad Syukri; Marwan; Hasibuan, Ahmad Daniel; Pratiwi, Eghinna Elsa; Hafsah, Nur; Oktafani, Reni; Fadhilla, Naylatul; Oktaviani, Dilla; Hendriansah; Putri, Popy Dwi; Amanda, Amelia; Muhadzid, Fayyadh Atsil; Dewi, Lativa Andam; Thoriq, Muhammad; Andrisyah, Fauzi; Azizi, Adni Salsabil; Yazid, Muhammad; Amalina, Azka; Naufal, Muhammad; Hanisa, Najma Syakina; Ramadhani, Nasywa Anjani; Mufadhdhal, Muhammad Asad
Warta Pengabdian Andalas Vol 32 No 4 (2025)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.32.04.446-454.2025

Abstract

The utilization of Family Medicinal Plants (TOGA) is a strategic effort to enhance community health self-reliance, reduce dependence on synthetic drugs, and preserve local biodiversity. In Nagari Batu Tanjung, Talawi District, Sawahlunto City, the potential for TOGA is high due to favorable geography and extensive backyard land. However, its use remains limited because of low herbal literacy, minimal organic cultivation skills, and the absence of a properly managed communal garden. This community service program aimed to empower residents through education, direct practice, and guidance in cultivating and processing medicinal plants. Activities included awareness sessions on TOGA’s benefits, land preparation, planting of herbal seeds (ginger, turmeric, cardamom, sungkai, Java turmeric, aloe vera), and the establishment of a model TOGA garden. Based on pre- and post-test results from 40 participants, knowledge and cultivation skills improved significantly—from 40% to 95% of participants understanding proper TOGA cultivation. Active collaboration among residents, village officials, and students ensured the program’s success. Through Q&A sessions and hands-on practice, the community gained practical skills suited to local conditions. The established TOGA garden now serves as a learning medium, a health-supporting initiative, and a foundation for developing herbal products that promote sustainable economic empowerment.
Co-Authors Amalina, Azka Amanda, Amelia Andrisyah, Fauzi Azizi, Adni Salsabil Dewi, Lativa Andam Dwisari Dillasamola Fadhilla, Naylatul Hafsah, Nur Hanisa, Najma Syakina Hasibuan, Ahmad Daniel Hendriansah Marwan Mufadhdhal, Muhammad Asad Muhadzid, Fayyadh Atsil Muhammad Naufal, Muhammad Muhammad Yazid Noverial Oktafani, Reni Oktaviani, Dilla Petrovsky, Ivan Pratiwi, Eghinna Elsa Putra Santoso Putri, Biomechy Oktomalio Putri, Popy Dwi Ramadhani, Nasywa Anjani Thoriq, Muhammad