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All Journal International Journal Of Science, Technology & Management (IJSTM) Eduvest - Journal of Universal Studies
Muchlisyam, Muchlisyam
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Mechanical Engineering Neuroscience Social Sciences Transportation

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Determination of The Level of Paracetamol and Tramadol Hcl Mixture in Tablets by Chemometric Method by Fourier Transform Infrared Spectrophotometry Purba, Gratia Apulina Cindylawsa; Muchlisyam, Muchlisyam; Putra, Effendy De Lux
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.50283

Abstract

Fixed-dose combinations of paracetamol and tramadol HCl are effective in the treatment of moderate to severe pain. Therefore, the determination of the levels of the mixture of paracetamol and tramadol HCl is very important for the pharmaceutical industry. The purpose of this study was to determine the levels of paracetamol and tramadol HCl mixture using Fourier Transform Infrared combined with partial least square (PLS) chemometric method. This study was conducted by making a calibration model and chemometric validation of each of the five concentrations measured absorbance at specific wave numbers of paracetamol and tramadol HCl. The results of the study on PLS multivariate calibration of paracetamol and tramadol HCl with RMSECV values of 0.06279 and 0.03785, PRESS values of 0.02366 and 0.00860, and R2 values of 0.9995  0.9998, respectively. All validation parameters are within the acceptable range.  This indicates that the method can be used to accurately determine drug levels without separation
Simultaneous Analysis of Tablets Content Vitamin C And Zinc In Visible Spectrophotometry Sulasmi, Sulasmi; Muchlisyam, Muchlisyam; Haro, Ginda
International Journal of Science, Technology & Management Vol. 4 No. 2 (2023): March 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i2.782

Abstract

Most drugs on the market contain multiple active ingredients, each of which is intended to enhance the drug's therapeutic effect and ease of administration. Determination of the levels of efficacious substances in drug preparations is essential for agencies that conduct drug determinations, such as the Food and Drug Supervisory Agency (BPOM) and the drug industry; therefore, a rapid and dependable analytical method, as well as relatively inexpensive and easily accessible tools and operational costs, are required. In practice, however, it can produce accurate and precise results. This research will be conducted by optimizing the solvent and simultaneously analyzing the levels of Vitamin C and Zinc in the tablet preparation without any separation step using visible spectrophotometry. Vitamin C and Zinc were found to be soluble in a mixture of methanol and water with a ratio of 50:50 after a single examination with the addition of the complexing agent dhitizon at a concentration of 0.1%, which produced a pink color. Calculation of Vitamin C and Zinc's linearity. The linearity value described is the correlation coefficient value for both Vitamin C and Zinc, which is very close to one, indicating an excellent relationship between the drug concentration and the absorbance value. This also suggests that absorbance will increase as concentration increases. The method validation requirements for linearity, accuracy, and precision as well as the limit of detection (LOD) and the limit of quantification (LOQ) were met by the analytical method validation with promising results.
Co-Authors Effendy De Lux Putra, Effendy De Lux Haro, Ginda Purba, Gratia Apulina Cindylawsa Sulasmi Sulasmi