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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical and Clinical Research
Haro, Ginda
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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PENETAPAN KADAR KALIUM, KALSIUM, NATRIUM DAN MAGNESIUM DALAM BUNGA NANGKA (Artocarpus eterophyllus Lam.) JANTAN SECARA SPEKTROFOTOMETRI SERAPAN ATOM Masfria, Masfria; Maulidar, Nanda Putri; Haro, Ginda
Media Farmasi: Jurnal Ilmu Farmasi Vol. 15 No. 2: September 2018
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v15i2.12659

Abstract

Nangka merupakan salah satu buah tropis yang keberadaannya tidak mengenalmusim. Tanaman nangka adalah tanaman berumah satu, artinya dalam satutanaman dapat dijumpai bunga jantan dan bunga betina. Mineral memegangperanan penting dalam pemeliharaan fungsi tubuh secara keseluruhan. Mineraldigolongkan dalalm mineral makro yang dibutuhkan dalam jumlah 100 mg seharidan mineral mikro kurang dari 100 mg sehari. Bunga nangka kurang populerdikalangan masyarakat dan belum ada penelitian terdahulu yang meneliti tentangkandungan dalam sampel tersebut. Tujuan penelitian ini adalah untuk mengetahuikandungan mineral kalium, kalsium, natrium dan magnesium dalam bunganangka jantan. Preparasi sampel dilakukan dengan proses dekstruksi kering.Penentuan kadar kalium, kalsium, natrium dan magnesium dilakukan denganmetode spektrofotometri serapan atom (SSA) masing-masing pada panjanggelombang 766,5 nm; 422,7 nm; 589,0 nm dan 285,2 nm dengan nyala udaraasetilen.Hasil penelitian menunjukkan bahwa kadar kalium, kalsium, natrium danmagnesium pada bunga nangka jantan yaitu [530,810] ± 2,760 mg/100g; [54,928]± 0,519 mg/100g; [16,087] ± 1,208 mg/100g dan [16,653]± 0,205 mg/100g
Cytotoxicity Activity of Ethanol Extract of Andaliman Fruits (Zanthoxylum acanthopodium DC.) towards 4T1 Breast Cancer Cells Rosidah, Rosidah; Hasibuan, Poppy Anjelisa Zaitun; Haro, Ginda; Satria, Denny
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (888.661 KB) | DOI: 10.32734/idjpcr.v2i2.3220

Abstract

Breast cancer is one of the world's leading cause of death in women. Due to the resistance of chemotherapeutic agents, there is a continuous need to search of natural products with anticancer activity. The use of natural products is expected to increase the effectiveness and decrease side effect. The purpose of this study was to investigate the anticancer activity of ethanol extract of andaliman fruits (EEAF) towards 4T1 cells. Extracts were prepared by maceration using solvent ethanol 96%. 4T1 cells were grown in culture medium DMEM then given by EEAF and doxorubicin. Cytotoxic test in vitro was done by MTT method [3-(4,5-dimetiltiazol-2-il) -2.5 difeniltetrazolium bromide] which is then analyzed using SPSS 21. The results from this study showed that the cytotoxic results (IC50) after treatment with EEAF and doxorubicin were 54.48 ± 0.22 µg/mL dan 0.80 ± 0.02 µg/mL.Based on the result above, we conclude that EEAF has cytotoxic activity towards 4T1 cancer cells. Key words: andaliman fruits, Zanthoxylum acanthopodium DC., ethanol extract, breast cancer, 4T1 cell line.
Co-Authors Denny Satria, Denny Hasibuan, Poppy Anjelisa Zaitun Masfria Maulidar, Nanda Putri Rosidah Rosidah