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All Journal Bioscientist : Jurnal Ilmiah Biologi
Raizma, Elda Zaelita Nurul
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Social Sciences

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Potensi Metabolit Sekunder Tanaman Syzygium sp. Terhadap LOX-1 Sebagai Target Terapi Penyakit Aterosklerosis: Studi In Silico Raizma, Elda Zaelita Nurul; Sopian, Devia Angelina; Alifianto, Handika Maulana; Eshananda, Yuriza; Simanjuntak, Sorta Basar Ida
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 1 (2025): March
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i1.14817

Abstract

Atherosclerosis is a cardiovascular disease characterized by the accumulation of oxidized lipoproteins in the arterial wall, which is triggered by LOX-1 receptor activation. The members of Syzygium genus contains secondary metabolites with antioxidant and anti-inflammatory activities that have the potential to inhibit LOX-1. This study aims to evaluate the interaction of compounds from Syzygium cumini, Syzygium aromaticum, Syzygium malaccense, and Syzygium jambos against LOX-1 using in silico method. Analysis was conducted through molecular docking, pharmacophore selection based on hydrophobic and hydrogen bond interaction criteria, and validation using Root Mean Square Deviation (RMSD ≤ 3 Å) values. The research results showed that gallic acid has the highest affinity (-4.1 kcal/mol), followed by linalool (-3.8 kcal/mol), kaempferol (-3.4 kcal/mol), oxalic acid (-3.4 kcal/mol), quercetin (-2.2 kcal/mol), and myricetin (-1.4 kcal/mol). The compounds with the highest affinity interacted with key LOX-1 residues, suggesting potential inhibition of the receptor. In conclusion, gallic acid is the most potent LOX-1 inhibitor candidate based on its stable interaction and highest affinity value. Further studies are needed to confirm its biological activity through in vitro and in vivo approaches.
Co-Authors Alifianto, Handika Maulana Eshananda, Yuriza Sopian, Devia Angelina Sorta Basar Ida Simanjuntak