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Journal : CERATA

Formulasi Krim Ekstrak Etanol Herba Patah Tulang (Euphorbia tirucalli L) 10% Dengan Variasi Nilai Hlb Tween 80 Dan Span 80 Sebagai Emulsifying Agent julia megawati; Nurul Farida; Wahid Sabaan; Yulis Trinovitasari
CERATA Jurnal Ilmu Farmasi Vol 11 No 2 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v11i2.141

Abstract

Euphorbia tirucalli L is a plant that has antimicrobial, antioxidant, antiviral, immunomodulatory properties, numb feet and hands. Euphorbia tirucalli L contain compounds including flavonoids and tannins. The research objective was to determine the differences in cream formulations with variations in the HLB values ​​of tween 80 and span 80 as emulsifying agents, to test the physical properties and stability of the cream preparations. Fractures were macerated extracted using ethanol 96% solvent. The resulting viscous extract was formulated in the form of cream type A / M with variations of Tween 80 and Span 80, the stability of the cream preparations obtained were tested for their stability including organoleptic, homogeneity, pH, adhesion, dispersion and viscosity testing, then continued by using the freeze thaw testing method. The results showed that the fracture herb ethanol extract could be formulated into a cream preparation that met the criteria by using tween 80 1.26 grams and span 80 3.74 grams with an HLB value of 7.
Uji Aktivitas Antibakteri Obat Kumur Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Terhadap Bakteri Streptococcus mutans Penyebab Karies Gigi Muhammad Nurul Fadel; Endang Setyowati; Yulis Trinovitawati; Wahid Sabaan
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v12i1.189

Abstract

Dental caries is a disease of the oral cavity caused by Streptococcus mutans bacteria. The mouthwash used continuously will cause side effects. So it is necessary to develop mouthwash preparations from natural ingredients, one of the plants is wuluh starfruit leaves (Averrhoa bilimbi L.) which contain flavonoids, tannins and saponins as antibacterial agents. The aim of this study was to determine the activity of the formulas for the mouthwash of wuluh starfruit leaves extract (Averrhoa bilimbi L.) which can affect the bacteria Streptococcus mutans. Research using the disc diffusion method, mouthwash made in 3 formulas, namely FI, FII, FIII with concentrations of 10%, 15% and 20%, which were placed on TSA media that had been overgrown with Streptococcus mutans bacteria incubated and the diameter of the inhibition zone (zone). clear). The results of the research on formula I (10%) on the first day get an average of 4.3 mm and day 14 get an average of 4 mm, this includes the classification of weak inhibition zones (less than 5 mm), formula II (15% ) get an average of 6.3 mm and day 14 get an average of 6 mm including the classification of moderate inhibition zone (5mm-10mm), formula III (20%) gets an average of 9.5mm and day 14 gets an average an average of 9.2 mm including the moderate inhibition zone classification (5mm-10mm), while the positive control (Povidone Iodine 1%) got an average of 13.8 mm and the 14th day got an average of 13.5 mm including the strong inhibition zone classification (more than 10mm) and negative control haven't drag zone. Based on the results of the data above, the formula of wuluh starfruit leaves mouthwash (Averrhoa bilimbi L.) can inhibit Streptococcus mutans bacteria.