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Uji Aktivitas Antibakteri Obat Kumur Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Terhadap Bakteri Streptococcus mutans Penyebab Karies Gigi Muhammad Nurul Fadel; Endang Setyowati; Yulis Trinovitawati; Wahid Sabaan
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Dental caries is a disease of the oral cavity caused by Streptococcus mutans bacteria. The mouthwash used continuously will cause side effects. So it is necessary to develop mouthwash preparations from natural ingredients, one of the plants is wuluh starfruit leaves (Averrhoa bilimbi L.) which contain flavonoids, tannins and saponins as antibacterial agents. The aim of this study was to determine the activity of the formulas for the mouthwash of wuluh starfruit leaves extract (Averrhoa bilimbi L.) which can affect the bacteria Streptococcus mutans. Research using the disc diffusion method, mouthwash made in 3 formulas, namely FI, FII, FIII with concentrations of 10%, 15% and 20%, which were placed on TSA media that had been overgrown with Streptococcus mutans bacteria incubated and the diameter of the inhibition zone (zone). clear). The results of the research on formula I (10%) on the first day get an average of 4.3 mm and day 14 get an average of 4 mm, this includes the classification of weak inhibition zones (less than 5 mm), formula II (15% ) get an average of 6.3 mm and day 14 get an average of 6 mm including the classification of moderate inhibition zone (5mm-10mm), formula III (20%) gets an average of 9.5mm and day 14 gets an average an average of 9.2 mm including the moderate inhibition zone classification (5mm-10mm), while the positive control (Povidone Iodine 1%) got an average of 13.8 mm and the 14th day got an average of 13.5 mm including the strong inhibition zone classification (more than 10mm) and negative control haven't drag zone. Based on the results of the data above, the formula of wuluh starfruit leaves mouthwash (Averrhoa bilimbi L.) can inhibit Streptococcus mutans bacteria.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 70% DAUN PEGAGAN (Centella asiatica L. Urban) TERHADAP BAKTERI Escherichia coli ATCC 25922 Arina Zulfah P; Ari Simbara; Dewi Septiyaningrum; Endang Setyowati
Prosiding University Research Colloquium Proceeding of The 12th University Research Colloquium 2020: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Daun pegagan (Centella asiatica L. Urban) memiliki senyawaantimikroba yang berkhasiat untuk mengatasi diare. Penelitian inibertujuan untuk mengetahui aktivitas ekstrak daun pegagan padaberbagai variasi konsentrasi dan untuk mengetahui perbandinganyang paling efektif dari berbagai varian konsentrasi tersebut. Daunpegagan diekstraksi menggunakan metode maserasi. Variankonsentrasi ekstrak etanol 70% daun pegagan dibuat seri konsentrasiyaitu 100 mg/ml; 50 mg/ml; 25 mg/ml; 12,5mg/ml; 6,25 mg/ml; 3,125mg/ml; 1,565 mg/ml; 0,781 mg/ml; 0,3905 mg/ml; kontrol negatif,dan kontrol positif serta kotrimoksazol sebagai kontrol pembanding.Pengujian dilakukan terhadap bakteri Escherichia coli ATCC 25922secara dilusi. Hasil uji antibakteri menunjukkan ekstrak etanol 70 %daun pegagan memiliki aktivitas antibakteri terhadap bakteriEscherichia coli ATCC 25922 dengan kadar bunuh minimal (KBM)100 mg/ml. Varian konsentrasi yang paling efektif adalah 100 mg/ml.Ekstrak etanol 70% daun pegagan terdapat kandungan flavonoid,alkaloid, tanin, saponin, dan glikosida triterpen.

Uji Aktivitas Antibakteri Obat Kumur Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Terhadap Bakteri Streptococcus mutans Penyebab Karies Gigi Muhammad Nurul Fadel; Endang Setyowati; Yulis Trinovitawati; Wahid Sabaan
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v12i1.189

Dental caries is a disease of the oral cavity caused by Streptococcus mutans bacteria. The mouthwash used continuously will cause side effects. So it is necessary to develop mouthwash preparations from natural ingredients, one of the plants is wuluh starfruit leaves (Averrhoa bilimbi L.) which contain flavonoids, tannins and saponins as antibacterial agents. The aim of this study was to determine the activity of the formulas for the mouthwash of wuluh starfruit leaves extract (Averrhoa bilimbi L.) which can affect the bacteria Streptococcus mutans. Research using the disc diffusion method, mouthwash made in 3 formulas, namely FI, FII, FIII with concentrations of 10%, 15% and 20%, which were placed on TSA media that had been overgrown with Streptococcus mutans bacteria incubated and the diameter of the inhibition zone (zone). clear). The results of the research on formula I (10%) on the first day get an average of 4.3 mm and day 14 get an average of 4 mm, this includes the classification of weak inhibition zones (less than 5 mm), formula II (15% ) get an average of 6.3 mm and day 14 get an average of 6 mm including the classification of moderate inhibition zone (5mm-10mm), formula III (20%) gets an average of 9.5mm and day 14 gets an average an average of 9.2 mm including the moderate inhibition zone classification (5mm-10mm), while the positive control (Povidone Iodine 1%) got an average of 13.8 mm and the 14th day got an average of 13.5 mm including the strong inhibition zone classification (more than 10mm) and negative control haven't drag zone. Based on the results of the data above, the formula of wuluh starfruit leaves mouthwash (Averrhoa bilimbi L.) can inhibit Streptococcus mutans bacteria.

HUBUNGAN KARAKTERISTIK DENGAN PERIODE RAWAT INAP PASIEN COVID-19 YANG MENDAPAT TERAPI FAVIPIRAVIR DIRUMAH SAKIT MITRA BANGSA PATI Hardiyani Presticasari; Nur Farida Ulfa; Eko Retnowati; Endang Setyowati
IJF (Indonesia Jurnal Farmasi) Vol 6, No 2 (2021): Indonesia Jurnal Farmasi
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v6i2.1763

Covid-19 merupakan penyakit yang disebabkan oleh virus SARS-CoV-2 (Servere Acute Respiratory Syndrome Coronavirus 2). Penularan Covid-19 sangat cepat sehingga pada tanggal 30 Januari 2020 WHO menyatakan Coronavirus sebagai KKMD. Tingginya kasus Covid-19 membuat kurangnya daya tampung fasilitas kesehatan, sehingga menjadikan pelayanan medis rawat inap kurang optimal dan memadai. Tujuan penelitian ini adalah untuk mengetahui hubungan karakteristik dengan periode rawat inap pada pasien Covid-19 yang mendapat terapi favipiravir di Rumah Sakit Mitra Bangsa Pati. Jenis penelitian observasional analitik dengan pendekatan Retrospective, dilakukan pada bulan Mei-Juni 2021 di Rumah Sakit Mitra Bangsa Pati. Pengambilan sampel secara Purposive Sampling, dan pengumpulan data menggunakan Rekam Medis pasien Covid-19. Jumlah sampel yang diperoleh sebanyak 59 responden, dan analisis data dilakukan dengan cara statistik menggunakan analisi bivariat dengan uji Chi Square.Hasil penelitian didapatkan Jenis kelamin terbanyak yaitu laki-laki 32 pasien (54,2%), usia terbanyak 46-59 berjumlah 29 pasien (49,2%), kemudian pasien Covid-19 paling banyak memiliki komorbid sebanyak 39 pasien (66,1%) dengan penyakit terbanyak adalah diabetes melitus sebanyak 19 pasien (32,2%). Hasil uji Chi Square diperoleh hubungan jenis kelamin dengan lama perawatan nilai p-value: 0,640, hubungan usia dengan lama perawatan nilai p-value 0,806, dan hubungan komorbid dengan lama perawatan nilai p-value 0,301. Tidak terdapat hubungan karakteristik dengan periode rawat inap pasien Covid-19 yang mendapat terapi favipiravir di Rumah Sakit Mitra Bangsa Pati

PERBANDINGAN EFEKTIVITAS PENURUNAN TEKANAN DARAH DENGAN PEMBERIAN KOMBINASI AMLODIPIN DENGAN KAPTOPRIL DAN AMLODIPIN DENGAN LISINOPRIL PADA PASIEN HIPERTENSI DI RUMAH SAKIT PKU MUHAMMADIYAH MAYONG JEPARA Endang Setyowati; Ezara Mila Fawwazah Prayitno; Yayuk Mundriyastutik; Ratna Dewi Isnaeni
IJF (Indonesia Jurnal Farmasi) Vol 6, No 2 (2021): Indonesia Jurnal Farmasi
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v6i2.1744

Hypertension is a non-communicable disease as well as one of the mortality factors in the world with a prevalence of 22% of the world's population. According to riskesdas, the prevalence of hypertension in Indonesia increased by 8.3% and 8.2% per year 2018. The selection and treatment of hypertension also requires the use of effective drugs and can provide good tolerance. The effectiveness as well as the benefits in the treatment of hypertension race on the measurement of blood pressure that has reached the target. The drop in blood pressure can also be influenced by the rational use of drugs both monotherapy and in combination. The purpose of this study was to analyze the comparison of the effectiveness of the use of drugs combination of amlodipine with captopril and amlodipine with lysinopril. This research method includes qualitative research using the cross sectional method with a retrospective approach. The results of the independent t-test of the significance value of the systolic category are 0.7810.05 and the significance value of the diastolic category is 0.9230.05. Pacidists who received combination therapy of amlodipine-captopril and amlodipine-lisinopril who achieved the targetse number of 43 patients. After independent t-test before and after therapy, it can be concluded that both the systolic category and the diastolic category regarding the effectiveness of the two combinations have no significant differences and the amlodipine-lysinopril combination is more effective in achieving the target of lowering blood pressure than amlodipine-captopril

PENGARUH EDUKASI TERHADAP PERSEPSI VAKSINASI COVID-19 MELALUI MEDIA LEAFLET DI DESA SUMBEREJO KABUPATEN PATI Endang Setyowati; Amalia Khoirunnisa; Yayuk Mundriyastutik; Ria Etikasari
IJF (Indonesia Jurnal Farmasi) Vol 6, No 2 (2021): Indonesia Jurnal Farmasi
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v6i2.1752

Pandemi virus corona menjadi masalah kesehatan masyarakat utama saat ini. Indonesia merupakan salah satu negara yang terkena dampak pandemi Covid-19. Dalam upaya penanggulangan pandemi Covid-19, vaksinasi Covid-19 ini bertujuan untuk mengurangi penularan Covid-19, menurunkan angka kesakitan dan kematian akibat Covid19. Hambatan utama pelaksanaan vaksinasi Covid-19 adalah keraguan masyarakat terhadap vaksin. Kurangnya informasi dan edukasi tentang vaksinasi menjadikan persepsi masyarakat terhadap vaksin menjadi negatif. Oleh karena itu, pemberian edukasi pada penelitian ini dimaksudkan untuk memberikan informasi mengenai vaksinasi Covid-19 sehingga persepsi terhadap vaksin Covid-19 tidak mengarah ke arah persepsi negatif. Penelitian ini dilakukan untuk menganalisis pengaruh edukasi melalui leaflet terhadap persepsi masyarakat terhadap vaksinasi Covid-19. Pada penelitian ini menggunakan jenis penelitian pra eksperimen one grup pretest postest dengan penedekatan studi cross sectional. Pengambilan sampel secara non probability sampling menggunakan pendekatan purposive sampling Hasil pretest dan postest menujukkan bahwa pada setiap kategori pertanyaan yang diberikan, hampir semua mengalami kenaikan nilia yang signifikan yaitu nilai postest lebih tinggi dari nilai pretest. Pada uji normalitas didapatkan hasil 0,017 lebih besar dari 0,05 yang menunjukkan data berdistribusi normal. Uji hipotesis t-test berpasangan didapatkan hasil 0,000 kurang dari 0,05 yang menunjukkan bahwa hipotesis (H1) diterima. Berdasarkan hasil data diatas dapat disimpulkan bahwa pemberian edukasi berpengaruh terhadap persepsi masyarakat Desa Sumberejo terhadap vaksinasi Covid-19. Kata Kunci : vaksin Covid-19, edukasi, persepsi

HUBUNGAN KARAKTERISTIK DENGAN PERIODE RAWAT INAP PASIEN COVID-19 YANG MENDAPAT TERAPI FAVIPIRAVIR Endang Setyowati; Rika Muharyanti; Ari Simbara; Nura Ali Dahbul
IJF (Indonesia Jurnal Farmasi) Vol 7, No 2 (2022): Indonesia Jurnal Farmasi
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v7i2.1753

Background: Covid-19 is a disease caused by the SARS-CoV-2 (Server acute respiratory syndrome coronavirus 2) virus. The transmission of Covid-19 was so fast the on January 30, 2020 WHO declared Coronavirus as KKMD. The high number of cases of Covid-19 has resulted in a lack of capacity for health facilities, thus making inpatient medical services less than optimal and adequate. Objective: To determine the relationship between characteristics with the period of hospitalization of Covid-19 patients receiving favipiravir therapy at the Mitra Bangsa Hospital, Pati.Methods: this type of analytic observational study with a retrospective approach, was conducted in May-June 2021 at Mitra Bangsa Hospital, Pati. Purposive sampling, and data collection using Covid-19 patient medical record. The number of sampels obtained was 59 respondents, and data analysis was carried out statistically using bivariat analysis with Chi Square test.Results: the most gender was male 32 patients (54.2%), the most age 46-59 as many 29 patients (49.2%), then Covid-19 patients had the most comorbidities as many as 39 patients (67.8%) with the most common disiase was diabetes melitus with 19 patiens (32.2%). The result of the Chi Square test showed that there was a relationship between gender with lengts of stay p-value: 0.640, relationship between age with length of stay p-value: 0.806, and comorbid relationship with length of stay p-value: 0.301.Conclusion: There is relationship between characteristics with the period of hospitalization of Covid-19 patients receiving favipiravir therapy at the Mitra Bangsa hospital Pati.Keywords: Covid-19, Favipiravir, Hospitalization

HUBUNGAN PENGETAHUAN PEMILIHAN TERHADAP PERILAKU PENGGUNAAN SUPLEMEN KESEHATAN DI DESA BLIMBINGREJO MELALUI PROMOSI KESEHATAN DENGAN MEDIA LEAFLET Nisa Oktadayana; Endang Setyowati; Yayuk Mundriyastutik
IJF (Indonesia Jurnal Farmasi) Vol 6, No 2 (2021): Indonesia Jurnal Farmasi
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v6i2.1767

Health supplements are medicinal preparations containing vitamins, minerals, and mutivitamins as a complement and nutritional needs. Inovercoming the covid-19 pandemic, preventive movement as one of the health behaviors, namely by living a healthy lifestyle, maintaining cleanliness, wearing masks, and intake of adequate nutrients to increase immunity. Of this study was to determine the relationship selection and behavior of use health supplements in village Blimbingrejo through health promotion with in the media leaflet. In this study use non-experimental observational research with one group pretest and posttest using a cross-sectional study approach. Non-probability sampling with purposive sampling or judgement sampling. The results of the pretest and posttest showed that in each given category there was a significant increase, namely the pretest value was higher than the posttest value. For the selection of supplements made by respondents and the behavior of using supplements were categorized as good after being given an understanding through leaflets. The results of the contigency coefficient test on the analysis of the behavior of using supplements pretest being given health promotion using leaflet media 0.346 ≥ 0.05 indicating that the hypothesis Ho (rejected). While the analysis of the relationship between selection knowledge and the behavior of using health suplements posttest 0.186 ≥ 0,05 indicated that the hypothesis Ho (rejected). Based on the results of the data it can be concluded that there is no relations between knowledge of selection and behavior in using health promotion using leaflet media. The results of the paired t-test unit for analysis of the relationship between selection knowledge and the behavior of using health suplements pretest and posttest obtained results of 0.000 0.05 there is a relationship knowledge selection using health supplements pretest and posttest being given health promotion with the media leaflet.Keywords: health supplements, knowledge selection, behavior health, and leaflet.

UJI EFEKTIVITAS EKSTRAK BUNGA TELANG (CLITORIA TERNATEA L.) SEBAGAI ANALGESIK PADA MENCIT (MUS MUSCULUS) Yayuk Mundriyastutik; Diana Tri Lestari; Endang Setyowati; Diah Putri Nugraheni; Yunita Rusidah
Jurnal Ilmu Keperawatan dan Kebidanan Vol 14, No 2 (2023): JURNAL ILMU KEPERAWATAN DAN KEBIDANAN
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/jikk.v14i2.1963

Nyeri adalah kondisi tidak nyaman, karena terdapat kerusakan jaringan. Pengobatan nyeri diberikan golongan analgesik. Ekstrak etanol (Clitoria ternatea L.) memiliki senyawa flavonoid, saponin, terpenoid, yang berpotensi sebagai analgesik, pada mencit yang diinduksi asam asetat. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanol dari tanaman clitoria ternatea L. terhadap penurunan geliat mencit, yang diinduksi asam asetat 1%, dengan metode pengamatan writing test setelah diberikan dosis ekstrak 200;300; dan 400 mg, dan induksi asam asetat secara intraperitoneal dengan menghitung rata-rata geliat mencit, selanjutnya analisis data menggunakan SPSS versi 26. Perbandingan dosis I (200 mg/KgBB) mendapatkan rata-rata geliat 2,5; dosis II (300 mg/KgBB) mendapatkan rata-rata geliat 3,02; dosis III (400 mg/KgBB mendapatkan rata-rata geliat 2,30; dan uji kontrol positif ibuprofen (26 mg/KgBB) mendapatkan rata-rata geliat 3,22. Penelitian ini dapat disimpulkan bahwa masing-masing dosis tanaman (Clitoria ternatea L.) memiliki daya analgesik, akan tetapi dosis yang memiliki efektivitas signifikan adalah dosis II (300 mg/KgBB).

SOSIALISASI STOP BULLYING SEBAGAI UPAYA PENCEGAHAN DAN EDUKASI DALAM MEWUJUDKAN LINGKUNGAN SEKOLAH YANG AMAN DAN NYAMAN BAGI SISWA Endang Setyowati; Irma Ravika; Andhika Setyawan; Adinda Triatna Maullidiyah; Fina Sari Arstianti; Fatika Oktasari; Riska Ardiana; Dwi Asmawati; Eni Istiqamah; Mila Umdatunnisa
Jurnal Abdimas Indonesia Vol 6, No 2 (2024): JURNAL ABDIMAS INDONESIA
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/jai.v6i2.2745

Bullying merupakan permasalahan yang masih sering terjadi di lingkungan sekolah dan dapat berdampak negatif pada perkembangan psikologis serta akademik siswa. Untuk mengatasi permasalahan ini, program pengabdian masyarakat bertajuk "Sosialisasi Stop Bullying di SMP 2 Jekulo" dilaksanakan dengan tujuan meningkatkan pengetahuan dan pemahaman siswa mengenai dampak bullying serta cara mencegahnya. Kegiatan ini mencakup pemberian materi edukatif mengenai jenis-jenis bullying, dampaknya terhadap korban dan pelaku, serta strategi pencegahan yang dapat diterapkan di lingkungan sekolah. Metode yang digunakan yaitu observasi dengan analisa data menggunakan deskriptif kuantitatif dengan sasaran 150 siswa. Hasil dari sosialisasi ini menunjukkan adanya peningkatan pemahaman siswa mengenai pentingnya menciptakan lingkungan sekolah yang aman, nyaman, dan bebas dari bullying. Dengan adanya program ini, diharapkan siswa dapat menjadi agen perubahan yang turut berperan dalam menciptakan budaya saling menghormati dan mendukung di lingkungan sekolah, sehingga tercipta suasana belajar yang kondusif bagi semua pihak.

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