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All Journal Jurnal SOLMA JURNAL FARMASIMED (JFM) Journal of Biotechnology and Natural Science Berita Biologi
Azali, Aulia Syafadilla
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Other

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Antioxidant Potential of the Asteraceae Family in Counteracting Free Radicals in Cigarette Smoke: An Overview Azali, Aulia Syafadilla; Rajab, Muhammad Andy; Lathifah, Sofiani; Akrom
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/4vbm3x10

Abstract

Cigarette smoke exposure triggers oxidative stress in the respiratory system through an increase in free radicals and a decrease in endogenous antioxidant activity, which contributes to lung damage and chronic diseases such as COPD and lung cancer. This study aims to investigate the potential of species from the Asteraceae family as a source of natural antioxidants in protecting the lungs and trachea from damage caused by exposure to free radicals in cigarette smoke. The method used is a Systematic Literature Review (SLR) with reference to the PRISMA 2020 guidelines. Literature searches were conducted systematically through the PubMed, ScienceDirect, and Google Scholar databases until June 2025. The inclusion criteria included in vivo studies using Asteraceae plant extracts in animals with induced oxidative stress in the respiratory system, as well as involving the measurement of biomarkers such as MDA, GSH, SOD, and CAT. Of the 198 articles found, 10 articles met the criteria and included species such as Tridax procumbens, Chromolaena odorata, Pulicaria petiolaris, and Baccharis retusa. The results showed that these species had significant antioxidant activity through their flavonoid, polyphenol, and triterpenoid compound content. However, most studies did not use a direct cigarette smoke exposure model. In conclusion, the Asteraceae family has great potential as a source of natural antioxidants to protect the respiratory system from oxidative stress, although further research with more relevant exposure models is needed. Toxicology and metabolomics approaches are also needed to strengthen the evidence for practical application in the treatment of lung diseases caused by cigarette smoke.
EFEK PROTEKTIF EKSTRAK SONGGOLANGIT (Tridax procumbens L.) TERHADAP HISTOPATOLOGI ORGAN PERNAPASAN TIKUS YANG DIPAPAR ASAP ROKOK Nurrohiim, Annisaa’; Setiawan, Haris; Wardani, Diah Kartika; Nurazizah, Intan Faya; Azali, Aulia Syafadilla
Berita Biologi Vol 23 No 1 (2024): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/beritabiologi.2024.2063

Abstract

Asap rokok merupakan salah satu sumber radikal bebas yang menyebabkan gangguan pada saluran pernapasan. Songgolangit (Tridax procumbens L.) merupakan salah satu tanaman potensial yang kaya antioksidan dan dapat menangkal radikal bebas seperti paparan asap rokok. Penelitian bertujuan untuk mengetahui potensi songgolangit untuk melindungi saluran pernapasan Tikus Wistar yang terpapar asap rokok. Penelitian menggunakan 25 ekor Tikus Wistar jantan, dengan 5 perlakuan yang terdiri dari K (pemberian akuades), KN (pemaparan asap rokok), P1 (pemaparan asap asap rokok dan pemberian ekstrak 100 mg/kg BB), P2 (pemaparan asap asap rokok dan pemberian ekstrak 200 mg/kg BB), dan P3 (pemaparan asap asap rokok dan pemberian ekstrak 300 mg/kg BB). Pemberian ekstrak dilakukan pada hari ke 1-21, sedangkan pemaparan asap rokok diberikan pada hari ke 8-21. Pada hari ke 22, tikus dieutanasi dan dibedah untuk diambil paru-paru dan trakeanya. Organ dipreparasi menggunakan metode parafin dan pewarnaan hematoksilin-eosin. Parameter pengamatan terdiri dari rasio organ paru-paru, luar inflamasi, jumlah sel edema, diameter paru-paru, tebal epitel trakea dan diameter trakea. Seluruh parameter data dianalisis menggunakan uji ANOVA dan uji lanjutan Duncan (p<0,05). Hasil penelitian menunjukan bahwa perbaikan paling signifikan pada rasio paru-paru, diameter alveolus, jumlah sel edema dan tebal epitel trakea terdapat pada dosis 300 mg/Kg BB (p<0,05), namun tidak ada perbedaan secara signifikan pada luas inflamasi dan diameter lumen trakea (p>0,05). Kesimpulan menunjukan bahwa pemberian dosis 300 mg/kg BB ekstrak songgolangit dapat melindungi struktur saluran pernapasan Tikus Wistar yang dipapar asap rokok.  
Edukasi Kehalalan dan Keamanan Produk Berbasis Literasi Komunikasi Digital di Gilangharjo Pandak Bantul Azali, Aulia Syafadilla; Nuh, Muhammad; Rahmawati, Dhea; Saraswati, Yasti Rizkandar; Yuliani, Sapto; Sari, Eka Anisa
Jurnal SOLMA Vol. 14 No. 3 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i3.20962

Abstract

Pendahuluan: Perkembangan teknologi digital membawa dampak besar pada penyebaran informasi, termasuk terkait kehalalan dan keamanan produk. Namun, literasi masyarakat, khususnya pelaku usaha mikro, kecil, dan menengah (UMKM), masih terbatas dalam memahami standar halal-thayyib dan keamanan pangan. Studi ini bertujuan untuk meningkatkan pemahaman masyarakat Desa Gilangharjo, Bantul melalui edukasi berbasis literasi komunikasi digital. Metode: Sosialisasi, pelatihan interaktif, simulasi penggunaan laman halal resmi, pendampingan, serta evaluasi. Hasil: Adanya peningkatan signifikan pengetahuan masyarakat dengan skor rata-rata pretest 41,53 meningkat menjadi 45,69 pada postest (p=0,000). Edukasi ini memberikan dampak positif yang merata tanpa dipengaruhi faktor usia maupun jenis kelamin. Kesimpulan: Edukasi kehalalan dan keamanan produk berbasis literasi digital efektif meningkatkan kesadaran masyarakat, mendorong perilaku konsumsi kritis, serta memperkuat kesiapan UMKM menghadapi sertifikasi halal nasional.
Study of Tridax procumbens L. Extract on SOD and MDA levels in Cingarette Smoke Exposed Rats setiawan, haris; Azali, Aulia Syafadilla; Wardani, Diah Kartika; Nurazizah, Intan Faya; Nurrohiim, Annisaa’
Journal of Biotechnology and Natural Science Vol. 5 No. 2 (2025): December
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jbns.v5i2.12948

Abstract

Cigarette smoke is a source of free radicals that can damage cells and tissues of the respiratory tract. Tridax procumbens L. has potential as an antioxidant because it contains flavonoids that play a role in counteracting free radicals. The study aims to determine the potential of Tridax procumbens L. as a source of antioxidants against SOD and MDA levels in Wistar rats exposed to cigarette smoke. The study used Wistar rats (25 heads) with 5 treatments consisting of K (aquadest), KN (exposed to cigarette smoke), P1 (exposed to cigarette smoke and given 100 mg/kg BW extract), P2 (exposed to cigarette smoke and given 200 mg/kg BW extract), and P3 (exposed to cigarette smoke and given 300 mg/kg BW extract). Extract administration was carried out on days 1-21 and cigarette smoke exposure was carried out on days 8-21. Parameters observed consisted of flavonoid content test (by KLT method, total flavonoid content, total phenolic content), body weight, SOD levels (whole blood method), and MDA levels (TBARs method). Data were analyzed by one-way ANOVA test (P<0.05) followed by Duncan post hoc test. The results showed that Tridax procumbens L. contains flavonoids with an Rf value of 0.23. Body weight showed no significant difference (P>0.05), but SOD and MDA levels were different between treatments (P<0.05) with the most optimum dose of 300 mg/kg BW. The conclusion shows that a dose of 300 mg/kg BW of ethanol extract of Tridax procumbens L. can act as a natural antioxidant from exposure to cigarette smoke in vitro.
Co-Authors Abda Abda Akrom, Akrom Aris Setiawan Lathifah, Sofiani Muhammad Nuh Nurazizah, Intan Faya Nurrohiim, Annisaa’ Rahmawati, Dhea Rajab, Muhammad Andy Sapto Yuliani Saraswati, Yasti Rizkandar Sari, Eka Anisa Wardani, Diah Kartika