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All Journal JURNAL FARMASIMED (JFM)
Lathifah, Sofiani
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Medicine & Pharmacology

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Antioxidant Potential of the Asteraceae Family in Counteracting Free Radicals in Cigarette Smoke: An Overview Azali, Aulia Syafadilla; Rajab, Muhammad Andy; Lathifah, Sofiani; Akrom
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/4vbm3x10

Abstract

Cigarette smoke exposure triggers oxidative stress in the respiratory system through an increase in free radicals and a decrease in endogenous antioxidant activity, which contributes to lung damage and chronic diseases such as COPD and lung cancer. This study aims to investigate the potential of species from the Asteraceae family as a source of natural antioxidants in protecting the lungs and trachea from damage caused by exposure to free radicals in cigarette smoke. The method used is a Systematic Literature Review (SLR) with reference to the PRISMA 2020 guidelines. Literature searches were conducted systematically through the PubMed, ScienceDirect, and Google Scholar databases until June 2025. The inclusion criteria included in vivo studies using Asteraceae plant extracts in animals with induced oxidative stress in the respiratory system, as well as involving the measurement of biomarkers such as MDA, GSH, SOD, and CAT. Of the 198 articles found, 10 articles met the criteria and included species such as Tridax procumbens, Chromolaena odorata, Pulicaria petiolaris, and Baccharis retusa. The results showed that these species had significant antioxidant activity through their flavonoid, polyphenol, and triterpenoid compound content. However, most studies did not use a direct cigarette smoke exposure model. In conclusion, the Asteraceae family has great potential as a source of natural antioxidants to protect the respiratory system from oxidative stress, although further research with more relevant exposure models is needed. Toxicology and metabolomics approaches are also needed to strengthen the evidence for practical application in the treatment of lung diseases caused by cigarette smoke.
Integrative Review of Indonesian Phytocosmetics: Resveratrol, Collagen, and Pachyrhizus erosus for Anti-Aging and Skin-Brightening in Multipurpose Serum Lathifah, Sofiani; Kintoko , Kintoko; Gulies Sentana, Pradanty Anaperta
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/nqkd8678

Abstract

Background: The demand for natural-based cosmetic products has increased substantially, driven by consumer awareness of safety, efficacy, and sustainability, with facial serums being preferred for anti-aging and skin-brightening applications. Objective: This review aimed to synthesise scientific evidence on the potential of resveratrol, marine collagen, and jicama (Pachyrhizus erosus) extract as key actives in multipurpose facial serum formulations with antioxidant, anti-ageing, and skin-brightening claims. Methods: A narrative review was conducted using original research articles published between 2015 and 2025 retrieved from PubMed and Crossref databases, focusing on quantitative outcomes including antioxidant and antityrosinase IC₅₀ values, changes in skin elasticity and hydration, transepidermal water loss (TEWL), and molecular biomarkers of skin ageing. Results: Of 1,393 identified records, 20 studies met the inclusion criteria (resveratrol n=6; collagen n=8; P. erosus n=6). Resveratrol shows strong antioxidant and anti-inflammatory activities that mitigate UV-induced photoaging; marine collagen, particularly hydrolysates, improves skin hydration and elasticity; and jicama extract provides antioxidant activity, including phenolic- and flavonoid-rich compounds, with tyrosinase inhibitory effects. Conclusion: Integrating these three actives may offer synergistic multi-target benefits; however, further formulation studies and clinical evaluations are required to confirm stability, compatibility, and combined efficacy within a single serum product.
Co-Authors Akrom, Akrom Azali, Aulia Syafadilla Gulies Sentana, Pradanty Anaperta Kintoko , Kintoko Rajab, Muhammad Andy