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All Journal Jurnal Mandala Pharmacon Indonesia Jurnal Farmasi Sains dan Praktis
Rajab, Muhammad Andy
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Immunology & microbiology Medicine & Pharmacology Public Health

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Formulation Optimization and Antibacterial Activity of Citronella (Cymbopogon nardus (L.) Rendle) Topical Gel Spray Against Staphylococcus aureus Using a Simplex Lattice Design Rajab, Muhammad Andy; Putri, Chintiana Nindya; Suryani, Arman; Salamah, Nina
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.867

Abstract

Atopic dermatitis is skin inflammation in the form of dermatitis caused by Staphylococcus aureus bacterial infection. Citronella essential oil has the potential as an active ingredient in spray gel preparations to help overcome atopic dermatitis due to Staphylococcus aureus bacterial infection. The aim is to determine the optimal spray gel formula from citronella essential oil (Cymbopogon nardus (L.) Rendle) and antibacterial activity against Staphylococcus aureus bacteria. The methods material optimized are Na-CMC, Propylene glycol, and tween 20. Evaluation of the preparation in the form of organoleptic tests, homogeneity, pH, viscosity, drying time, spraying patterns, yeast mold numbers using the spread plate method, and antibacterial activity against Staphylococcus aureus bacteria using the good diffusion method. The results of the concentration of Na-CMC: Propylene glycol: Tween 20 (0.27: 4.72: 10) produced an optimal preparation formula. The spray gel is milky white, has a distinctive lemongrass odor, and is slightly thick. The spray gel is homogeneous with a pH of 4.94 ± 0.16, a viscosity of 76.73 ± 7.01 cPs, and a drying time of 3.60 ± 0.40 minutes. The mold/yeast count test showed that the spray gel was free from mold/yeast contamination and was stable at storage temperatures of 4?C and 40?C. The results of antibacterial activity were able to inhibit Staphylococcus aureus bacteria with an inhibition zone diameter of 6.85 mm ± 2.80. Conclusion: Na-CMC concentration of 0.27%, Propylene Glycol concentration of 4.72%, and Tween 20 concentration of 10% produced optimal spray gel and inhibited Staphylococcus aureus.
THE EFFECT OF EDUCATIONAL VIDEOS AS AN EFFORT TO IMPROVE THERAPY SUCCESS USING THE HEALTH BELIEF MODEL APPROACH: PERCEPTION OF SEVERITY Sundari, Trias Kania; Rajab, Muhammad Andy; Mukaromah, Diyana Latifatul; Afidah, Malikatul; Kamiela, Annisa Azkiya; Sulistyaningrum, Indriyati Hadi
Jurnal Farmasi Sains dan Praktis Vol 12 No 1 (2026)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/hpgsk614

Abstract

Patient compliance with hypertension treatment is often a problem in therapy, so pharmacists and other health workers need to make an effort to improve patients' understanding of the disease and complications that can occur when patients do not take their medication, in order to achieve the clinical outcome of controlled blood pressure. This study aims to determine the effect of educational videos accompanied by the health belief model component of perceived severity on the compliance of hypertensive patients at the Gayamsari Community Health Center in Semarang. The method used in this study was a quasi-experiment using a pre-test and post-test group control conducted on 52 samples of Prolanis Hypertension patients who met the inclusion criteria at the Gayamsari Community Health Center in Semarang City, who were given the MARS (Medication Adherence Rate Scale) questionnaire. Results: From the intervention group that received educational videos accompanied by the health belief model component of perceived severity, the Wilcoxon signed rank test results had a p-value of 0.001, which means that there was a difference in patient compliance scores between the pretest and posttest. Meanwhile, the difference in post-test results between the two groups (control and intervention) also showed significance in the Mann-Whitney U Test with a p-value of 0.000, meaning that educational videos with health belief model components can influence the adherence of hypertensive patients at the Gayamsari Community Health Center in Semarang City. Conclusion: Showing educational videos accompanied by health belief model components to hypertensive patients at the Gayamsari Community Health Center in Semarang City can significantly influence patient compliance with p<0.05.
Co-Authors Afidah, Malikatul Indriyati Hadi Sulistyaningrum Kamiela, Annisa Azkiya Mukaromah, Diyana Latifatul Nina Salamah Putri, Chintiana Nindya Sundari, Trias Kania Suryani, Arman