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All Journal International Journal of Health and Pharmaceutical (IJHP) Cerdika: Jurnal Ilmiah Indonesia
Muhammad Gugun, Adang
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Humanities Economics, Econometrics & Finance Education Health Professions Nursing Public Health Social Sciences

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THE EFFECT OF DYSLIPIDEMIA ON THE INCIDENCE OF CORONARY HEART DISEASE IN WOMEN Muhammad Gugun, Adang; Sheina Fernanda, Aldina; Ardia Pramono, Nabila; Pradhipta Cahya, Sartika; Febri Ferryana, Vella
Cerdika: Jurnal Ilmiah Indonesia Vol. 4 No. 1 (2024): Cerdika : Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v4i1.739

Abstract

Coronary heart disease (CHD) is one of the non-communicable diseases that causes the highest mortality in the world. Dyslipidemia is an important risk factor for CHD. This study aims to determine the relationship of dyslipidemia in detail including increased cholesterol, increased triglycerides, increased LDL cholesterol and decreased HDL cholesterol on the incidence of CHD in women at PKU Muhammadiyah Hospital Yogyakarta. This study used a case-control design involving 58 women as research subjects. The case group consisted of 29 women diagnosed with CHD and the control group consisted of 29 women diagnosed as non-CHD patients, including chronic lung disease, pneumonia, heart failure, dyspepsia and malignancy. Data tracing through medical records was carried out in March-September 2019. The results of this study the age range in the case group was 45-84 years and in the control group was 42-90 years. Based on the Chi-Square test, there was a significant relationship between dyslipidemia (RO = 7.04 (1.73-28.6), p = 0.003), high total cholesterol levels (RO = 5.14 (1.54-17.2), p = 0.012), high LDL cholesterol levels (RO = 9.286 (2.29-37.6), p = 0.001) and the incidence of CHD in women. From the Chi-Square test there was no significant relationship between high triglyceride levels (OR=2.16 (CI:0.62-7.49), p=0.358), low HDL cholesterol levels (RO=2,554 (0.83-7.84), p=0.167) and CHD incidence in women. The conclusion of this study is the effect of dyslipidemia including increased cholesterol and LDL cholesterol on the incidence of CHD in women at PKU Muhammadiyah Hospital Yogyakarta.
The Difference In Potassium Levels In Fresh Blood Bags With Blood Bags Stored At Pku Muhammadiyah Gamping Hospital Suryanto, Suryanto; Muhammad Gugun, Adang; Nurpratami, Diah
Cerdika: Jurnal Ilmiah Indonesia Vol. 4 No. 2 (2024): Cerdika : Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v4i2.758

Abstract

Blood transfusion, one of them, is a process of transferring blood components containing glucose, lactate, and potassium. During storage, blood cells undergo metabolic changes such as decreased blood pH, hemolysis, and increased potassium levels. One of the complications of transfusion that must be avoided is hyperkalemia due to the release of potassium. This study aimed to determine differences in stored blood potassium levels and PRC QC results during 11 days of storage. This was an analytic observational study with a cross sectional approach. A T-test was used to analyze the difference. In addition, PRC blood quality control (QC) was also carried out for stored blood according to standards. This study used 40 samples of fresh blood bags obtained from UTD PMI Yogyakarta City. The mean potassium level in fresh blood bags was 4.373 ± 0.417 mmol/L (3.70-5.50) and the average potassium level in blood bags stored for 6 days was 8.290 ± 0.275 mmol/L (7.80-8.90). There was a significant difference in potassium levels between fresh blood bags and blood bags stored for 6 days (p = 0.000). The overall QC PRC result is 50% which indicates the need for improvement in terms of the blood component separation process.
The Effect of Initial Anti-tuberculosis Drug Therapy on Transminase Enzymes Muhammad Gugun, Adang; Suryanto, Suryanto; Ranti Ayuningtyas, Dyah Nova
Cerdika: Jurnal Ilmiah Indonesia Vol. 4 No. 3 (2024): Cerdika : Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v4i03.762

Abstract

Tuberculosis is still a health problem in the world. TB treatment is carried out in 2 phases, namely early and advanced. This study aims to determine changes in serum transaminase enzyme levels (SGOT and SGPT) in pulmonary TB patients before and after initial drug administration. This study was observational with a cohort study design study. Observations were conducted in tuberculosis patients who received initial ATD therapy for 2 months for SGOT and SGPT enzyme levels before and after treatment. The subject of the study was a new case of a pulmonary TB patient aged ?16 years. Subjects received initial therapy in the form of isoniazid, rifampicin, pyrazinamide, and ethambutol. Recruitment of subjects through successive sampling methods with informed consent. Using a spectrophotometer, SGOT and SGPT enzyme tests were performed on the median blood serum cubital vein. Data analysis using the Wilcoxon Test. The study involved 19 subjects (10 men and 9 women) aged 16-65 years. Before ATD, the mean SGOT was 22.84 IU/L, and SGPT was 21.37 IU/L. After ATD, SGOT increased to 58.63 IU/L (p = 0.023), and SGPT to 80.84 IU/L (p = 0.007). Of the 19 subjects, 8 experienced a significant increase in SGOT and 5 SGPT. Five cases showed an increase in SGPT in line with SGOT, and 3 cases showed an increase in SGOT without SGPT. One case saw an increase in SGOT and SGPT of more than 5 times the reference value. This study confirms an increase in transaminase enzymes during initial therapy with first-line ATD.
Hba1c and Blood Pressure Correlation In Patients With Uncontrolled Type 2 Diabetes Mellitus Muhammad Gugun, Adang; Suryanto, Suryanto; Emil Fadli Nugroho, Muhammad; Bintang Bari, Pravda
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 4 (2024): November 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i4.257

Abstract

The primary metabolic disorder in diabetes mellitus is hyperglycemia, which can be assessed through glycated hemoglobin (HbA1c) levels as an indicator of long-term blood glucose control. Abnormal glucose metabolism may affect vascular function and contribute to increased blood pressure, making hypertension a common complication among patients with uncontrolled diabetes mellitus. This study aimed to determine the correlation between HbA1c levels and blood pressure in patients with uncontrolled type 2 diabetes mellitus. An observational cross-sectional study was conducted at RSU PKU Muhammadiyah Gamping involving 90 subjects aged 31–65 years, consisting of 48 men and 42 women. HbA1c levels were measured using the boronate affinity method, and blood pressure was assessed with a sphygmomanometer. Statistical analysis used the independent t-test, Mann–Whitney U test, and Spearman correlation with a significance level of α = 0.05. The mean HbA1c level was 10 ± 2.08%, mean systolic pressure 132.75 ± 18.04 mmHg, and mean diastolic pressure 83.28 ± 10.38 mmHg. Hypertension occurred in 36.66% of subjects. The results showed no significant differences in blood pressure between sexes or glycemic control groups and no significant correlation between HbA1c levels and blood pressure. These findings suggest that factors other than glycemic control may influence blood pressure in diabetic patients.
Co-Authors Ardia Pramono, Nabila Bintang Bari, Pravda Emil Fadli Nugroho, Muhammad Febri Ferryana, Vella Nurpratami, Diah Pradhipta Cahya, Sartika Ranti Ayuningtyas, Dyah Nova Sheina Fernanda, Aldina Suryanto Suryanto