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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Multidisiplin Madani (MUDIMA)
Rosnizar
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Industrial & Manufacturing Engineering Materials Science & Nanotechnology Physics Social Sciences

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Study of Antioxidant Activity and Hepatoprotector Potential of Ethanol Extracts of Bark Mezzettia Parviflora Becc. on Liver Function of Wistar Strain Rats (Rattus Novergicus L.) Masykur; Nurdin; Hakim, Lukman; Rosnizar; Sari, Widya; Husna, Asmaul; Ceriana, Ria
Jurnal Multidisiplin Madani Vol. 4 No. 5 (2024): May 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i5.9038

Abstract

This study aims to analyze the hepatoprotective potential of ethanol extract of Mezzetia Parviflora Becc. stem bark. (EEKBM) on serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels in rats induced by toxic doses of paracetamol, as well as measuring the antioxidant concentration of EEKBM. The method used in this research was a Completely Randomized Design (CRD) consisting of 6 treatment groups and 4 replications. The test animals used were 24 individual male rats that were induced by hepatotoxicity with 1350 mg/kgBW of paracetamol on day 7, except for the normal control (K0) which was given distilled water. Test animals received treatment with distilled water in the negative control (K-), Hepa-Q as much as 11.34 mg/kgBW in the positive control (K+), EEKBM dose of 150 mg/kgBW (P1), dose of 300 mg/kgBW (P2), and a dose of 600 mg/kgBB (P3) for 14 days. Data on SGOT and SGPT levels were analyzed using Analysis of Variance (ANOVA) with a significance level of 5% with the Tukey test as a further test. The results of the study showed that there was a significant difference (P<0.05) in the effect of giving EEKBM on SGOT and SGPT levels. Based on the research results, it was concluded that a dose of 150 mg/kgBB EEKBM has hepatoprotective potential. Spectrophotometric measurement results show that EEKBM has an IC50 value of 96.308 μg/mL, categorized as strong antioxidant activity
Effect of Ethanol Extract of Sugar Apple (Annona squamosa L.) Stem Bark on Rat SGPT and SGOT Masykur, Masykur; Nurdin; Hakim, Lukman; Rosnizar; Sari, Widya; Ulfa, Munira; Sari, Novi Yana; Ceriana, Ria
Jurnal Penelitian Pendidikan IPA Vol 9 No 10 (2023): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i10.4773

Abstract

This study aims to compare hepatoprotector potency of the ethanol extract of sugar apple (A. squamosa) stem bark (EESSB) against the enzyme activity of SGOT and SGPT in rats induced by toxic doses of paracetamol. The method used in this study is Completely Randomized (CRD) consisting of 6 treatment groups and 3 replications. The parameters that are being observed in this study are phytochemical, antioxidant, clinical symptoms, macroscopic, SGOT and SGPT rats. Data were analyzed using Analysis of Variance (ANOVA) with a significant level of 5% with the Duncan test as a follow-up test. The clinical and macroscopic symptoms of rat liver including changes in color, surface structure and consistency as well as relative organ weight. Data were analyzed using ANOVA significant level 5% and Duncan's test as a follow-up test.  Extracts contains alkaloid, steroid and phenolic compounds. The results showed that there was a significant difference (P <0.05) in the levels of SGOT and SGPT after giving ethanol extract of stem bark A.squamosa (EESSB). Based on the results of the study, it was concluded that all EESSB doses had the potential to reduce the levels of AST and ALT in paracetamol induced rats. The results showed that there was a significant difference (P <0.05) in the macroscopic changes in the liver based on changes in color and degree of liver damage. Relative organ weight had no significant effect (P> 0.05). The ethanol extract of  A. squamosa (EESSB) stem bark has the potential to be a hepatoprotector, however a dose of 150 mg/kg BW is a more effective dose as a hepatoprotector against paracetamol.
Co-Authors Asmaul Husna Lukman Hakim Masykur Masykur, Masykur Nurdin Ria Ceriana, Ria Sari, Novi Yana Ulfa, Munira Widya Sari