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Ria Ceriana, Ria
Bagian Klinik Hewan, Fakultas Kedokteran Hewan, Universitas Udayana, Bali
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Comparison of Phytochemical Screening of Ethanol Extracts from The Skin, Seeds, and Fruit of Aceh Rambai (Baccaurea motleyana Mull.Arg) Ceriana, Ria; Andayani, Thursina; Yuliana, Cut; Hizqiya Al Zuhra, Cut; Nadia, Ayu; Siti Baitul Mikraj; Susila Indrayani, Pocut; Arafah, Siti
The Health Researcher's Journal Vol. 1 No. 01 (2024): The Health Researchers Journal
Publisher : The SDGS Forum Communication

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Abstract

One of Indonesia's potentially rich plant species is the rambai (Baccaurea motleyana Muell.Arg). The rambai (Baccaurea motleyana Muell.Arg) belongs to a group of fruit-producing plants that grow wildly in Southeast Asian territories, such as Thailand, Malaysia, and Indonesia, particularly in Sumatra and Kalimantan. Closely related to the menteng/kepundung fruit family, the rambai plant is also found in the Aceh region. Known locally as rambe, it grows in the wild and has not been specifically cultivated. The fruit, along with its skin and seeds, has not been utilized specifically by the community for medicinal purposes, making this research significant. Furthermore, there has been no study on the phytochemical screening of various phytochemical contents in the skin and seeds of the rambai fruit. The objective of this study is to qualitatively determine the phytochemical screening results and contents in the ethanol extract of the skin and seeds of the rambai fruit (Baccaurea motleyana Muell. Arg). This research aims to add to the information on the phytochemical richness of the rambai fruit and serve as an initial reference for studies on the extracts of the fruit's skin, seeds, and flesh (Baccaurea motleyana Muell.Arg). The method for preparing the ethanol extract of the skin, seeds, and flesh of the rambai fruit was carried out through maceration using 96% alcohol solvent. The findings of this study indicate that the ethanol extracts of the fruit's skin and seeds contain the same chemical compounds, namely terpenoids, saponins, flavonoids, and phenolics/tannins.
Daya Analgesik Ekstrak Daun Picisan (Polypodium nummulariifolium Mett) Pada Mencit Putih Ceriana, Ria; Mukhlisa, Ida; Zafis, Fathiya Imaniyyah; Safira, Ulfia; Pratiwi, Silvia Putri; Desi, Navira Nava; Husni, Barada; Rumaida, Rumaida; Kinanti, Kinanti; Adisah, Nur; Putri, Virda
Science: Indonesian Journal of Science Vol. 1 No. 2 (2024)
Publisher : LPPI Yayasan Almahmudi bin Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/science.v1i2.15

Abstract

Pengalaman empirik tentang pemanfaatan aneka herba dalam seni pengobatan dunia timur telah menarik perhatian masyarakat barat untuk mempelajari lebih lanjut tanaman herba sebagai sumber obat- obatan masa depan. Daun picisan termasuk dalam famili Polypodiaceae. Daun picisan memiliki berbagai manfaat diantaranya dapat digunakan sebagai antinyeri atau analgesik. Penelitian ini menggunakan sampel dan konsentrasi yang berbeda dari penelitian sebelumnya dimana sampel diambil berasal dari daerah Aceh Besar dengan volume 0,5 ml. Oleh karena itu, penelitian ini perlu dilakukan untuk mengetahui daya analgesik ekstrak daun picisan (Polypodium nummulariifolium Mett) pada mencit putih. Penelitian ini menggunakan 3 kelompok perlakuan yaitu akuades, ekstrak daun picisan dan obat Ibuprofen. Perlakuan tersebut diulang sebanyak 3 kali. Data dianalisis secara deskriptif yang ditampilkan dalam bentuk tabel. Kesimpulan dari penelitian ini adalah ekstrak daun picisan memiliki daya analgesik yang dapat terlihat dari penurunan jumlah lompatan pada mencit.
FORMULASI SEDIAAN GEL EKSTRAK ETANOL BUNGA SOKA (Ixora coccinea L) SEBAGAI TERAPI INFEKSI PADA KULIT YANG DISEBABKAN OLEH BAKTERI Staphyloccocus aureus Lestari, Widya; Shafriyani, Rini; Ceriana, Ria
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 8, No 2 (2022): OKTOBER 2022
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v8i2.4190

Abstract

Penelitian tentang pemanfaatan tanaman sebagai obat telah banyak dilakukan salah satunya tanaman soka (Ixora coccinea L.). Ekstrak etanol dari bunga soka (Ixora coccinea L.) memiliki kandungan flavonoid, alkaloid, glikosida, terpenoid dan karbohidrat. Data rata-rata selisih diameter sebelum dan sesudah diolesi gel ekstrak etanol bunga asoka dianalisis secara deskriptif, penyembuhan infeksi dinilai dengan parameter diameter luka pada infeksi dan berapa hari luka sembuh total. Semakin kecil diameter luka pada infeksi semakin baik penyembuhan yang terjadi, Formulasi yang bagus untuk penyembuhan infeksi adalah gel konsentrasi 10% ekstrak bunga soka yang terbukti dapat menyembuhkan luka infeksi pada mencit dengan dilihat pengurangan diameter luka sampai hari 11. Hasil pengujian stabilitas gel memenuhi syarat untuk sediaan gel yaitu homogenitas daya lekat, daya sebar dan uji pH.Kata kunci : Bunga soka (Ixora Coccinea L.), Infeksi luka, Gel ekstrak bunga soka.A lot of research has been conducted on the use of plants as drugs, and one of them is Ashoka (Ixora coccinea L.). Ethanol extract from Ashoka flower (Ixora coccinea L.) contains flavonoids, alkaloids, glycosides, terpenoids, and carbohydrates. The data on the average diameter difference, before and after applying the Ashoka ethanol extract gel, were analyzed descriptively, infection healing was assessed by the diameter of the wound in the infection and by the number of days required by the wound to recover. The smaller the wound diameter in infection, the better the healing process is. The best formulation for healing infection is at 10% concentration of Ashoka flower extract gel. It was proven to cure infection wounds in mice based on the reduction of the wound diameter by Day 11. The results of the stability test on the gel show that homogeneity, adhesivity, spreadability, and pH have met the requirements for the gel preparations.Keywords : Ashoka flower (Ixora coccinea L.), Infection wound, extract gel of Ashoka flower
Pengetahuan Masyarakat Desa Doy Kecamatan Ulee Kareng Kota Banda Aceh tentang Obat Tradisional Ceriana, Ria; Verawati; Masykur
Jurnal Mitra Pengabdian Farmasi Vol. 2 No. 2 (2023): Februari 2023
Publisher : Akademi Farmasi YPPM Mandiri

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Abstract

Community service aims to help improve knowledge, skills and public health. This service is carried out to find out and increase the knowledge of the people of Doy Village, Ulee Kareng District, Banda Aceh City regarding traditional medicine. Traditional medicine has been used by people for generations to treat various diseases. This community service was held in June 2022 in Doy Village, Ulee Kareng District, Banda Aceh City, attended by around 20 participants. This activity uses a lecture and counseling model accompanied by a questionnaire instrument to see the level of public knowledge about traditional medicine. The results of this activity are known that the community is 100% about knowing and using traditional medicine. However, about 80% of those who have just planted TOGA plants in their yards. Then after the service was carried out by means of counseling, there was an increase in public knowledge to 100%. Based on this activity it is known that there are about 17 types of plants used by the people of Doy Village as traditional medicine.
Effectiveness of ethanol extract of rambai fruit peel (Baccaurea motleyana Mull. Arg.) on the hematological profile of diabetic mice Ceriana, Ria; Meutia, Savira; Kiti, Annisa Ammalia; Lidyawati, Lidyawati
Open Science and Technology Vol. 3 No. 2 (2023): Open Science and Technology
Publisher : Research and Social Study Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33292/ost.v3i2.103

Abstract

Penelitian ini bertujuan mengetahui pengaruh ekstrak etanol kulit buah rambai (Baccaurea motleyana Mull. Arg.) terhadap profil hematologi mencit jantan (Mus musculus) guna mengetahui dosis yang efektif dalam meningkatkan profil hematologi mencit jantan, serta untuk mengetahui toksisitas ekstrak etanol kulit buah rambai. Penelitian ini menerapkan Rancangan Acak Lengkap (RAL) yang terdiri dari enam perlakuan, yaitu mencit diabetes yang diberi akuades (kontrol negatif) (P1), mencit diabetes yang diberi obat glibenklamid (kontrol positif) (P2), serta mencit diabetes yang diberi ekstrak etanol kulit buah rambai pada dosis 200 mg/kg berat buah (bb) (P3), 400 mg/kg bb (P4), 800 mg/kg bb (P5), dan 1.600 mg/kg bb (P6). Terdapat empat replikasi untuk masing-masing perlakuan. Data yang diperoleh dianalisis secara statistik menggunakan ANOVA dan diuji lanjut menggunakan uji Duncan (DMRT) pada tingkat kepercayaan 95%. Hasil studi ini menunjukkan bahwa ekstrak etanol kulit buah rambai berpengaruh nyata terhadap kadar hemoglobin, jumlah eritrosit, dan jumlah leukosit mencit jantan. Dosis terbaik untuk meningkatkan kadar hemoglobin adalah 400 mg/kg bb. Dosis terbaik untuk meningkatkan jumlah eritrosit adalah 1600 mg/kg bb. Semua dosis perlakuan ekstrak mampu meningkatkan jumlah leukosit. This study aims to determine the effect of ethanol extract of rambai fruit peel (Baccaurea motleyana Mull. Arg.) on the hematological profile of male mice (Mus musculus), to determine the effective dose in increasing their hematological profile, and to determine the toxicity of the ethanol extract of rambai fruit peel. This study applied completely randomized design (CRD) consisting of six treatments: diabetic mice treated with distilled water (negative control) (P1), diabetic mice treated with glibenclamide drug (positive control) (P2), and diabetic mice treated with ethanol extract of rambai fruit peel at a dose of 200 mg/kg fruit weight (fw) (P3), 400 mg/kg fw (P4), 800 mg/kg fw (P4), and 1,600 mg/kg fw (P6). There were four replications for each treatment. The data obtained were statistically analyzed using ANOVA and further tested using DMRT at a 95% confidence level. The results show that the ethanol extract of rambai fruit peel significantly affected the hemoglobin levels, the number of erythrocytes, and the number of leukocytes of the mice. The best dose to increase the hemoglobin levels was 400 mg/kg fw. The best dose to increase the number of erythrocytes was 1600 mg/kg fw. All extract doses was able to increase the number of leucocytes.  
Study of Antioxidant Activity and Hepatoprotector Potential of Ethanol Extracts of Bark Mezzettia Parviflora Becc. on Liver Function of Wistar Strain Rats (Rattus Novergicus L.) Masykur; Nurdin; Hakim, Lukman; Rosnizar; Sari, Widya; Husna, Asmaul; Ceriana, Ria
Jurnal Multidisiplin Madani Vol. 4 No. 5 (2024): May 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i5.9038

Abstract

This study aims to analyze the hepatoprotective potential of ethanol extract of Mezzetia Parviflora Becc. stem bark. (EEKBM) on serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels in rats induced by toxic doses of paracetamol, as well as measuring the antioxidant concentration of EEKBM. The method used in this research was a Completely Randomized Design (CRD) consisting of 6 treatment groups and 4 replications. The test animals used were 24 individual male rats that were induced by hepatotoxicity with 1350 mg/kgBW of paracetamol on day 7, except for the normal control (K0) which was given distilled water. Test animals received treatment with distilled water in the negative control (K-), Hepa-Q as much as 11.34 mg/kgBW in the positive control (K+), EEKBM dose of 150 mg/kgBW (P1), dose of 300 mg/kgBW (P2), and a dose of 600 mg/kgBB (P3) for 14 days. Data on SGOT and SGPT levels were analyzed using Analysis of Variance (ANOVA) with a significance level of 5% with the Tukey test as a further test. The results of the study showed that there was a significant difference (P<0.05) in the effect of giving EEKBM on SGOT and SGPT levels. Based on the research results, it was concluded that a dose of 150 mg/kgBB EEKBM has hepatoprotective potential. Spectrophotometric measurement results show that EEKBM has an IC50 value of 96.308 μg/mL, categorized as strong antioxidant activity
Effect of Ethanol Extract of Sugar Apple (Annona squamosa L.) Stem Bark on Rat SGPT and SGOT Masykur, Masykur; Nurdin; Hakim, Lukman; Rosnizar; Sari, Widya; Ulfa, Munira; Sari, Novi Yana; Ceriana, Ria
Jurnal Penelitian Pendidikan IPA Vol 9 No 10 (2023): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i10.4773

Abstract

This study aims to compare hepatoprotector potency of the ethanol extract of sugar apple (A. squamosa) stem bark (EESSB) against the enzyme activity of SGOT and SGPT in rats induced by toxic doses of paracetamol. The method used in this study is Completely Randomized (CRD) consisting of 6 treatment groups and 3 replications. The parameters that are being observed in this study are phytochemical, antioxidant, clinical symptoms, macroscopic, SGOT and SGPT rats. Data were analyzed using Analysis of Variance (ANOVA) with a significant level of 5% with the Duncan test as a follow-up test. The clinical and macroscopic symptoms of rat liver including changes in color, surface structure and consistency as well as relative organ weight. Data were analyzed using ANOVA significant level 5% and Duncan's test as a follow-up test.  Extracts contains alkaloid, steroid and phenolic compounds. The results showed that there was a significant difference (P <0.05) in the levels of SGOT and SGPT after giving ethanol extract of stem bark A.squamosa (EESSB). Based on the results of the study, it was concluded that all EESSB doses had the potential to reduce the levels of AST and ALT in paracetamol induced rats. The results showed that there was a significant difference (P <0.05) in the macroscopic changes in the liver based on changes in color and degree of liver damage. Relative organ weight had no significant effect (P> 0.05). The ethanol extract of  A. squamosa (EESSB) stem bark has the potential to be a hepatoprotector, however a dose of 150 mg/kg BW is a more effective dose as a hepatoprotector against paracetamol.
Co-Authors Adisah, Nur Arafah, Siti Asmaul Husna Desi, Navira Nava Hery Widijanto Hizqiya Al Zuhra, Cut Husni, Barada Kinanti Kinanti, Kinanti Kiti, Annisa Ammalia Lidyawati, Lidyawati Lukman Hakim Masykur Masykur, Masykur Meutia, Savira Mukhlisa, Ida Nadia, Ayu Nurdin Pratiwi, Silvia Putri Putri, Virda Rosnizar Rumaida, Rumaida Safira, Ulfia Sari, Novi Yana Shafriyani, Rini Siti Baitul Mikraj Susila Indrayani, Pocut Thursina Andayani Ulfa, Munira Verawati Widya Sari Yuliana, Cut Zafis, Fathiya Imaniyyah