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All Journal Indonesian Journal of Pharmaceutical and Clinical Research
Rambe, Rima Elfitra
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Identifikasi Drug Related Problems Pada Pasien Penyakit Ginjal Kronis Di Rumah Sakit Prof. dr. Chairuddin Panusunan Lubis Tahun 2023 Rudang, Singgar Ni; Rambe, Rima Elfitra; Annisa, Sheyla
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.18031

Abstract

Chronic kidney disease (CKD) is an abnormality of kidney structure or function, present for ≥ 3 months, with implications for health. The high number of medications used by CKD patients can increase the potential for Drug-Related Problems (DRPs) which can interfere with desired health outcomes. This study aimed to determine the occurrence of DRPs in chronic kidney disease patients admitted to Prof. dr. Chairuddin Panusunan Lubis Hospital in 2023. This study was a descriptive retrospective cross-sectional study conducted. Data were obtained from the medical records of CKD inpatients in 2023 (n=51). The sampling technique used was total sampling. The occurrence of DRPs was identified based on the Pharmaceutical Care Network Europe (PCNE) V9.1 classification, which includes problems categories (P1-P3) and causes (C1-C6). There were 28 females (54.90%) and 23 males (45.10%), with an average age of 46.8±11.5 years. The highest stage of CKD was stage 5 (78.43%). The most common comorbid condition was anemia (84.31%), with the most frequently used medication being antihypertensives in the Calcium Channel Blocker class (88.24%). Among the 51 medical records, 21 (41,17%) showed the occurrence of DRPs, consisting of 26 Problems (P) categorized under P1. Treatment effectiveness (46,15%) and P2. Treatment safety (53,85%), and 26 Causes (C) categorized under C1. Drug selection (57,69%) and C3. Dose selection (42,31%). Drug-Related Problems (DRPs) occurred in chronic kidney disease patients admitted to Prof. dr. Chairuddin Panusunan Lubis Hospital in 2023.
MEDICATION SAFETY PROFILE: A CASE REPORT OF FIRST TRIMESTER PREGNANCY PATIENTS WITH DEEP VEIN THROMBOSIS DIAGNOSIS ACCOMPANIED BY COMORBIDITY Aritonang, Anggi Chatie Yunida; Rambe, Rima Elfitra; Henny Sri Wahyuni; Lumbanraja, Sarma Nursani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 02 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i02.21822

Abstract

Pregnancy is a hypercoagulable state that elevates the risk of Deep Vein Thrombosis (DVT). The selection of pharmacological interventions for DVT during pregnancy necessitates rigorous consideration of both maternal and fetal safety. Management becomes increasingly complex when the condition is accompanied by comorbidities, which often lead to polypharmacy and a higher potential for drug-drug interactions. This case report discusses a 33-year-old pregnant woman in her first trimester diagnosed with DVT in the left lower extremity, complicated by secondary hypertension, type 2 diabetes mellitus, and fever. The therapeutic regimen comprised 13 medications, including anticoagulants, antibiotics, analgesic-antipyretics, antiemetics, antihypertensives, and antidiabetic agents. Medication safety profiles were evaluated based on FDA pregnancy categories and other peer-reviewed references. Potential drug interactions were analyzed using the UpToDate® Lexicomp™ database. The study identified two drugs in category A, five in categories B and C, respectively, and one agent for which data was unavailable. Four potential drug interactions were identified, ranging from moderate to minor severity. All prescribed drugs demonstrated an adequate safety profile supported by current clinical literature. This study emphasizes the critical importance of a thorough risk-benefit analysis. Stringent monitoring is essential to ensure both the safety and efficacy of the treatment.
Co-Authors Annisa, Sheyla Aritonang, Anggi Chatie Yunida Henny Sri Wahyuni Rudang, Singgar Ni Sarma Nursani Lumbanraja