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All Journal Journal of Islamic Pharmacy Jurnal Biologi Tropis JURNAL PENDIDIKAN TAMBUSAI Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM) JOURNAL LA MEDIHEALTICO JUKESHUM: Jurnal Pengabdian Masyarakat Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Journal of Pharmaceutical and Sciences. Jurnal Perilaku Kesehatan Terpadu
Rudang, Singgar Ni
Departemen Farmakologi Dan Farmasi Klinis/Komunitas, Fakultas Farmasi, Universitas Sumatera Utara, Medan, 20155, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary

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Sedative Test of Ethanol Extract of Putri Malu Leaves (Mimosa Pudica Linn.) in Mice (Mus Musculus) With Standardized Herbal Medicine Lelap as Comparison Jefri Naldi; Indra Ginting; Singgar Ni Rudang; Suci Ramadayanti
Journal La Medihealtico Vol. 3 No. 2 (2022): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v3i2.579

Abstract

Dense activity and with increasing age experienced by each community, is one of the causes of decreased sleep quality and trigger sleep disorders. The use of medicinal plants is increasingly in the community such as Sensistive plant leaves. This study aims to determine the sensitive plants and to know the comparison of the work activities of the sensitive plants leaves with a deep sleep. This research was an experimental study with a complete random design in a unidirectional pattern. Test animals used 15 male mice, divided into 5 groups randomly consisting of 3 animals. First Group was given a 0.5% CMC suspension, Second group was given a deep suspension, Third group was given an sensitive plants leaves extract with 5% concentration, fourth group was given an sensitive plants leaves extract of 10% concentration, fifth group was given an sensitive plants leaves extract of 20%. Data obtained by Anova test, followed by Duncan's different test to see the real difference in each experimental group. Administration of sensitive plants leaves extract of 5% leaves did not make a significant difference with sleep, but at a concentration of 10%, 20% gave a significant difference with sedative test on mice that were given a deep sleep. Suspension of sensitive plants leave has a sedative effect on mice, at a concentration of 10%, 20% has the same sedative effect as deep sleep, and research needs to be done on other parts of the sensitive plants leaves that has a stronger sedative effect.
Edukasi Covid-19, Pembuatan Hand Sanitizer, dan Sosialisasi Cuci Tangan yang Baik dan Benar dalam Rangka Pemberdayaan Siswa Sebagai Apoteker Cilik di UPT SDN 060796 Medan Singgar Ni Rudang; Embun Suci Nasution; Nurul Aini; Murobbi Murobbi
TRI DHARMA MANDIRI: Diseminasi dan Hilirisasi Riset kepada Masyarakat (Jurnal Pengabdian kepada Masyarakat) Vol 2, No 2 (2022)
Publisher : JTRIDHARMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2022.002.02.98

Abstract

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberdayakan siswa sebagai apoteker cilik. Kegiatan pengabdian kepada masyarakat dilakukan karena pada umumnya siswa sekolah dasar masih kurang mengenal profesi apoteker dan belum mengetahui cara penggunaan obat yang tepat terutama pada masa pandemi seperti saat ini. Selain itu, siswa sekolah dasar masih kurang mengetahui tentang cara pencegahan dari Covid-19. Oleh sebab itu, tim pengabdi memberikan edukasi tentang profesi apoteker, cara penggunaan obat yang tepat, pencegahan Covid-19, serta sosialisasi cuci tangan yang baik dan benar. Metode yang digunakan pada kegiatan ini adalah pengembangan metode berbasis keaktifan siswa yaitu modifikasi Cara Belajar Insan Aktif (CBIA). Untuk meningkatkan keterampilan siswa, tim pengabdi juga memberikan penyuluhan pembuatan hand sanitizer alami. Kegiatan ini dievaluasi melalui hasil pre-test dan post-test. Dari hasil analisis pre-test dan post-test diketahui bahwa terdapat peningkatan pengetahuan siswa. Kesimpulan dari kegiatan ini adalah edukasi yang diberikan mampu meningkatkan pengetahuan dan pemahaman siswa mengenai profesi apoteker, cara penggunaan obat yang tepat, gejala Covid-19, cara Covid-19 menginfeksi tubuh, dan cara pencegahannya. Selain itu, terdapat peningkatan keterampilan siswa-siswi dalam membuat hand sanitizer alami.
Uji aktivitas antibakteri kombinasi ekstrak kulit dan biji Pepaya (Carica papaya L.) terhadap bakteri Staphylococcus aureus dan Escherichia coli Indra Ginting; Singgar Ni Rudang; Muhammad Andry; Mayang Sari; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.262

Abstract

Background;; Infectious diseases suffered by many people include Enterobacter infection from E.coli and skin infections due to S. aureus. One of the plants that have antibacterial properties is papaya like seeds and skin. Objekctives; The purpose of this study was to determine the activity of papaya skin and Seed (Carica papaya L.) extracts against S. aureus and E.coli. Method; The study used experimental method. The extraction used was maceration with ethanol 80%, 60% solvent. 40% and 20%. Antibacterial Activity Test using disc diffusion method and phytochemical screening test on papaya skin extract (Carica papaya L). Result; The results of screening tests on papaya skin extract (Carica papaya L) were positive for alkaloids, saponins, tannins, flavonoids and steroids. The results obtained at 60% ethanol showed that the combined extract of papaya skin and seeds (Carica papaya L) on S. aureus with concentrations (20:80) - (80:20) was 11.9 mm - 15.6 mm. In E. coli with a concentration (20:80) - (80:20) of 9.7 mm - 14.9 mm. Conclusion; The conclusions from the results of research on the combination of papaya skin and papaya seeds (Carica papaya L) of various concentrations inhibited S.aureus bacteria more than E.coli bacteria.
Toxicity Test of Ethanol Extract of Gagatan Harimau Leaves (Vitis Gracilis BL.) on Artemia Salina Leach Larvae Using Brine Shrimp Lethal Test (BSLT) Method Surbakti, Chemayanti; Rimayani Nasution, Lisda; Ni Rudang, Singgar; Cintya, Henni; Vany, I.; Agnes, P.A.T.; Elsa, S.E.S.
International Journal of Science, Technology & Management Vol. 4 No. 6 (2023): November 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i6.963

Abstract

Gagatan harimau leaves (Vitis gracilis BL) is a plant contains several secondary metabolite compounds, namely alkaloids, glycosides, tannins, saponins and flavonoids and has been used traditionally to treat diarrhea, infectious diseases, inflammation and diabetes. The aim of this study was to to determine data on the percentage of deaths and the LC50 value of the ethanol extract of the Gagatan harimau (Vitis gracilis BL) against Artemia Salina Leach using the Brine Shrimp Lethality Test (BSLT) method. The method used is the Brine Shrimp Lethality Test (BSLT) with concentrations of 180 ppm; 200 ppm; 220ppm; 240ppm; 260ppm; 280ppm; 300 ppm and 0 ppm as negative controls each replicated three times. At each concentration, 10 Artemia salina Leach larvae were used as test animals, each concentration was 48 hours old. The toxic effect of the extract was determined by the percentage mortality of Artemia salina Leach larvae using probit analysis (LC50). The results of this research gave the linear regression equation Y = 11.674x-68.227. Therefore, the LC50 value is 6.275 and the LC50 gets a value is 187.068 ppm. Research on the toxicity of Gagatan harimau (Vitis gracilis BL.) ethanol extract using the BSLT (Brine Shrimp Lethality Test) method in this study is toxic because the LC50 is < 1000 ppm so it has the potential to be anticancer.
Formulasi Sediaan Lulur Krim Dari Ekstrak Etanol Daun Pepaya (Carica papaya L.) Sebagai Pelembab Kulit Leny, Leny; Rudang, Singgar Ni; Ginting, Indra; Simanjuntak, Heppy Taruli
Journal of Islamic Pharmacy Vol 8, No 1 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i1.20793

Abstract

Pengelupasan kulit diperlukan dalam membuang atau mengangkat sel-sel permukaan kulit yang mati dan kering serta dapat membuat tekstur kulit menjadi merata dan halus. Eksfolian fisik seperti scrub bekerja untuk mengelupaskan kulit mati secara instan. Kebanyakan orang mungkin tidak cocok melakukan eksfoliasi setiap hari, karena dapat menyebabkan kulit menjadi kering dan mudah teriritasi. Untuk itu, senyawa alami yang digunakan dalam pembuatan lulur dapat menjadi pilihan yang lebih baik dalam mengangkat sel mati sekaligus menutrisi kulit dengan banyak senyawa antioksidan. Daun pepaya mengandung senyawa kimia yang bersifat antiseptik, antiradang, antijamur, dan antibakteri. Senyawa antibakteri yang terdapat pada daun pepaya antara lain tanin, flavonoid, alkaloid, terpenoid, dan saponin. Selain itu, daun pepaya mengandung vitamin C dan E (masing-masing 68,59 dan 39,78mg/100 g). Tujuan dari penelitian ini adalah memformulasi sediaan krim lulur ekstrak etanol 70% dari daun pepaya yang memiliki kemampuan dalam meningkatkan kelembaban. Penelitian dilakukan secara eksperimental, meliputi pembuatan simplisia, ekstrak, sediaan lulur krim dan pemeriksaan sediaan secara fisik maupun efektivitasnya terhadap kulit sukarelawan. Studi menunjukkan bahwa tidak ada perubahan bentuk, warna dan bau setelah 12 minggu penyimpanan; uji homogenitas menunjukkan preparat homogen; sediaan menunjukkan kisaran pH 6,5-6,9; jenis emulsi adalah fase minyak dalam air sehingga krim mudah diaplikasikan, menyebar dan didispersikan dengan air; tes iritasi menunjukkan tidak ada kemerahan, gatal dan panas pada kulit sukarelawan. Dapat disimpulkan bahwa ekstrak etanol 70% dari daun pepaya (Carica papaya L.) dapat diformulasikan sebagai krim lulur dan dengan konsentrasi 15% ekstrak daun pepaya memberikan efek terbaik dalam meningkatkan kelembaban kulit. 
Comparison of Effectiveness and Duration of Recovery in Acne Treatment Using a Topical Approach Systemics and Lasers Ginting, Indra; Mukhali, Hassan Basri Bin; Abas, Mohd Ihsanuddin Bin; Aji, Andrey; Rachelli, Rachelli; Dakhi, Tiwanto; Rudang, Singgar Ni
Jurnal Pendidikan Tambusai Vol. 9 No. 1 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v9i1.25438

Abstract

Jerawat adalah kondisi kulit kronis yang dapat memengaruhi kualitas hidup penderitanya. Penelitian ini bertujuan untuk membandingkan kemanjuran dan durasi pemulihan dari tiga metode pengobatan jerawat utama: topikal, sistemik, dan laser. Pendekatan retrospektif dilakukan dengan menganalisis data pasien yang menjalani perawatan di klinik dermatologi, menggunakan IGA (Investigator's Global Assessment) untuk menilai keparahan jerawat dan skor CADI (Cardiff Acne Disability Index) untuk mengevaluasi dampak terhadap kualitas hidup. Hasil penelitian menunjukkan bahwa terapi laser memiliki efektivitas tertinggi dengan penurunan skor CADI sebesar 90% dalam waktu 4 minggu dan durasi pemulihan rata-rata 8 minggu, lebih cepat dibandingkan terapi sistemik (10 minggu) dan topikal (12 minggu). Kepuasan pasien tertinggi tercatat pada kelompok terapi laser dengan skor 4,7, diikuti terapi sistemik dan topikal masing-masing 4,2 dan 3,8. Meskipun terapi laser lebih mahal, terapi sistemik tetap efektif untuk jerawat sedang hingga berat, dan terapi topikal lebih cocok untuk jerawat ringan meski membutuhkan waktu pemulihan lebih lama. Penelitian ini menyarankan agar pemilihan terapi didasarkan pada tingkat keparahan jerawat, durasi pemulihan, dan preferensi pasien, memberikan panduan bagi praktisi dermatologi dalam merancang pengobatan yang optimal.
Edukasi Covid-19, Pembuatan Hand Sanitizer, dan Sosialisasi Cuci Tangan yang Baik dan Benar dalam Rangka Pemberdayaan Siswa Sebagai Apoteker Cilik di UPT SDN 060796 Medan Rudang, Singgar Ni; Nasution, Embun Suci; Aini, Nurul; Murobbi, Murobbi
TRI DHARMA MANDIRI: Dissemination and Downstreaming of Research to the Community (Journal of Community Engagement) Vol 2 No 2 (2022)
Publisher : SMONAGENES Research Center, Univeritas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2022.002.02.98

Abstract

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberdayakan siswa sebagai apoteker cilik. Kegiatan pengabdian kepada masyarakat dilakukan karena pada umumnya siswa sekolah dasar masih kurang mengenal profesi apoteker dan belum mengetahui cara penggunaan obat yang tepat terutama pada masa pandemi seperti saat ini. Selain itu, siswa sekolah dasar masih kurang mengetahui tentang cara pencegahan dari Covid-19. Oleh sebab itu, tim pengabdi memberikan edukasi tentang profesi apoteker, cara penggunaan obat yang tepat, pencegahan Covid-19, serta sosialisasi cuci tangan yang baik dan benar. Metode yang digunakan pada kegiatan ini adalah pengembangan metode berbasis keaktifan siswa yaitu modifikasi Cara Belajar Insan Aktif (CBIA). Untuk meningkatkan keterampilan siswa, tim pengabdi juga memberikan penyuluhan pembuatan hand sanitizer alami. Kegiatan ini dievaluasi melalui hasil pre-test dan post-test. Dari hasil analisis pre-test dan post-test diketahui bahwa terdapat peningkatan pengetahuan siswa. Kesimpulan dari kegiatan ini adalah edukasi yang diberikan mampu meningkatkan pengetahuan dan pemahaman siswa mengenai profesi apoteker, cara penggunaan obat yang tepat, gejala Covid-19, cara Covid-19 menginfeksi tubuh, dan cara pencegahannya. Selain itu, terdapat peningkatan keterampilan siswa-siswi dalam membuat hand sanitizer alami.
Formulation of Natural Food Coloring Granules from Dragon Fruit Peel Extract (Hylocereus polyrhizus) and Effectiveness Test in Reducing Blood Glucose Levels Rudang, Singgar Ni; Ginting, Indra; Andry, Muhammad
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7635

Abstract

Anthocyanin is one of the many compounds in dragon fruit skin that can be used as an antioxidant. Dragon fruit skin can also lower blood glucose levels. The fact that cases of diabetes mellitus are increasing every year shows that this disease needs serious treatment. This study aims to make dragon fruit skin extract formulated in the form of granules and make dragon fruit skin extract granules that meet the requirements as natural food coloring and to determine the content and effectiveness of dragon fruit skin extract (Hylocereus polyrhizus) which can lower blood glucose levels. This research method is experimental. The One Way Anova test and the Tukey HSD post-hoc test were used to analyze the data. The outcomes showed that there were 9 granule recipes that met the assessment test necessities. After being induced by 20% fructose solution, the glucose level study revealed that the treatment of dragon fruit skin extract at 100, 200, and 400 mg / kgBW was able to lower blood glucose levels in test animals. Winged serpent natural product skin concentrate can be formed as granules. Equations 2 and 3 produce the best tone. The consequences of the review reasoned that winged serpent natural product skin remove (Hylocereus polyrhizus) at dosages of 100, 200 and 400 mg/kgBW was viable in decreasing blood glucose levels in guinea pigs prompted by 20% fructose arrangement and a portion of 200 mg/kgBW gave an impact of lessening blood glucose levels that was practically equivalent to the positive control.
Formulation and Evaluation of Facial Wash Gel Preparation from Celery Leaf Ethanol Extract (Apium graveolens L.) Against Staphylococcus aureus Bacteria Ginting, Indra; Mukhali, Hassan Basri bin; Abas, Mohd Ihsanuddin Bin; Aji, Andrey; Rachelli, Rachelli; Andry, Muhammad; Sibero, Jitasari Tarigan; Rudang, Singgar Ni
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8500

Abstract

Facial wash is a facial cleansing soap that can clean oil and cosmetics that stick to the face. Usually facial wash has a low pH or close to the skin's normal pH, namely 4.5-6.5 and contains milder detergent. Researchers are to determine which celery leaf extract (Apium graveolens L.) is being evaluated as a facial wash preparation and to determine which facial wash preparation has inhibitory power for the growth of Staphylococcus aureus bacteria. This research is experimental using the maceration method. The sample used in this research was 10 kilograms of celery leaves. Results : Testing the pH of the celery leaf ethanol extract facial wash gel preparation for each F0, F1, F2 and F3 showed that the pH of the celery leaf ethanol extract facial wash gel preparation decreased due to the presence of acid compounds in celery leaves, causing the pH to decrease slightly but still within the pH range. topical, namely 4.5-7.0 and the pH of the celery leaf ethanol extract facial wash gel preparation above shows a relatively neutral pH which is still safe for the skin. The facial wash gel preparation of ethanol extract of celery leaves (Apium graveolens L.) has an inhibitory zone containing Staphylococcus aureus bacteria in K(+), K(-), F1 (5%), F2 (10%) and F3 (15%) with strong inhibition zone category. Researchers found that the ethanol extract of celery leaves can be formulated in the form of a facial wash gel. It is recommended that further research be carried out on the effectiveness of celery leaves with different concentrations and methods.
Formulation and Evaluation of a Sheet Mask with Ethanol Extract of Mengkudu (Morinda citrifolia L.) as a Moisturizing Agent Ginting, Indra; Mukhali, Hassan Basri bin; Abas, Mohd Ihsanuddin Bin; Aji, Andrey; Rachelli, Rachelli; Rudang, Singgar Ni
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8551

Abstract

Facial skin often faces issues such as acne, dullness, and dryness. Sheet masks are one of the cosmetic care products that can help maintain facial skin hydration. Noni leaves (Morinda citrifolia L.) contain secondary metabolite compounds such as alkaloids, tannins, saponins, and flavonoids, which can act as antioxidants.  To determine whether noni leaf ethanol extract can be formulated into a sheet mask preparation and its effectiveness as a moisturiser. The research involved several steps: plant identification/determination, sample collection, extraction using the maceration method with 70% ethanol solvent, formulation of the sheet mask preparation, and evaluation, including organoleptic tests, homogeneity, pH, stability, irritation, and moisture effectiveness testing using a skin analyser. Sheet mask preparations with 5%, 7%, and 10% concentrations were found to be thick, homogeneous, with pH ranging from 4.42 to 5.72, non-irritating, stable during storage, and increased skin moisture by 78.94% for F1, 84.0% for F2, and 85.15% for F3. Noni leaf ethanol extract can be formulated into sheet mask preparations and is effective in moisturising the skin. Keywords: Noni leaf extract, sheet mask, moisture.
Co-Authors Abas, Mohd Ihsanuddin Bin Agnes, P.A.T. Aini Nurul Aji, Andrey Annisa, Sheyla Bayu Aji, Andreas Cintya, Henni Dakhi, Tiwanto Elsa, S.E.S. Embun Suci Nasution Fajar Putra, Adika Ginting, Indra Ginting, Indra Tahir Indra Ginting Ismanelly Hanum, T. Jefri Naldi Leny Leny, Leny Mayang Sari Muhammad Amin Nasution Muhammad Andry Mukhali, Hassan Basri bin Murobbi Murobbi Murobbi, Murobbi Nadaresta, Maria Nasution, Embun Suci Nurhaz Siregar, Arfah Nurul Aini Putri Yolanda Barus, Dwi Rachelli, Rachelli Rambe, Rima Elfitra Rimayani Nasution, Lisda Sibero, Jitasari Tarigan Simanjuntak, Heppy Taruli Sormin, Tessa Sri Rohani, Ade Suci Nasution, Embun Suci Ramadayanti Sumaiyah, Sumaiyah Surbakti, Chemayanti Syafitri, Rachelli Nova Vany, I.