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All Journal Jurnal Riseta Naturafarm
Dewi, Jingga Apriani Jevita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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The Potential of Carbon Monoxide (CO) as a Therapeutic Agent in Cancer Treatment: A Literature Review: Potensi Karbon Monoksida Sebagai Agen Terapeutik Dalam Pengobatan Kanker: Tinjauan Literatur Samsul, Erwin; Dewi, Jingga Apriani Jevita; Agustina, Inayah Yuli; Atmadja, Meilda Keysia Angelica; Rombe, Irene Aliet; Nabilah, Cindy; Sari, Mila Kansia; Putri, Nur Arinda
Jurnal Riseta Naturafarm Vol. 2 No. 2 (2025): Jurnal Riseta Naturafarm
Publisher : B-Creta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jrn.v2i2.5664

Abstract

Background: Carbon monoxide (CO) has shown potential as an anti-cancer therapy, rather than simply functioning as a toxin. Recent research indicates that carbon monoxide (CO), which is a carbon-based nanoparticle, can target cancer cells and induce apoptosis. CO shows promising cytotoxic activity against cancer cell lines as one of the therapies in cancer treatment. The purpose of this article is to present a concise look at the physiological and biochemical traits of CO and the mechanism of its therapeutic potential in the treatment of cancer Methods: This study is a literature review. The database used in the search for this article using google scholar, pubmed, and elsevier. the data collection process uses the keywords “Carbon Monoxide, cancer, anti- cancer therapy” which are taken from the results of research that has been done previously both from within and outside the country. The results of this research article review are Carbon Monoxide (CO) not only has a toxic effect but also has a cytotoxic effect on cancer cells. In cancer cells treated with CO, there was a significant reduction in Akt (protein kinase B) phosphorylation, a key factor in cancer neovascularization, by 30-50%.
Preclinical Review of the Antidiarrheal Potential Herbal Plants: Kajian Potensi Antidiare Tanaman Herbal secara Praklinik Arief, Maryam Jamila; Robin, Yosepha Vania Usun; Sheila, Annieza; Bidang, Diani Kristiani; Dewi, Jingga Apriani Jevita; Wijayanti, I Dewa Ayu Made Dwita; Rahmadania, Siti Nur
Jurnal Riseta Naturafarm Vol. 3 No. 1 (2026): J Riseta Naturafarm
Publisher : B-Creta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jrn.v3i1.1018

Abstract

Diarrhea remains a major gastrointestinal health problem, highlighting the need for safe and effective alternative therapies, including those derived from traditional medicinal plants. This review aims to evaluate the antidiarrheal potential of various medicinal plants based on preclinical evidence. A narrative review approach was employed by searching the Google search engine using the keyword “antidiarrheal” for scientific publications published between 2018 and 2025. The included literature consisted of preclinical studies using in vivo and/or in vitro approaches. The medicinal plants reviewed included Piper betle L., Eugenia polyantha, Zingiber officinale, Mangifera indica, Psidium guajava L., Curcuma longa L., Pithecellobium jiringa, Crescentia cujete L., fermented Hylocereus polyrhizus, Centella asiatica, Pometia pinnata, Moringa oleifera L., Strobilanthes crispus, and Cuminum cyminum. The findings indicate that these plants exhibit antidiarrheal activity through multiple mechanisms, including antibacterial effects against enteric pathogens, inhibition of intestinal motility, antispasmodic effects, and reduction of intestinal fluid secretion, which are closely associated with the presence of secondary metabolites such as flavonoids, tannins, alkaloids, terpenoids, and phenolic compounds. Several plants demonstrated antidiarrheal efficacy comparable to loperamide at specific doses, suggesting their potential as alternative antidiarrheal agents. However, further studies involving extract standardization, identification of active marker compounds, safety evaluation, and clinical trials are required to confirm their efficacy and safety in humans.
Co-Authors Agustina, Inayah Yuli Arief, Maryam Jamila Atmadja, Meilda Keysia Angelica Bidang, Diani Kristiani Erwin Samsul Nabilah, Cindy Putri, Nur Arinda Rahmadania, Siti Nur Robin, Yosepha Vania Usun Rombe, Irene Aliet Sari, Mila Kansia Sheila, Annieza Wijayanti, I Dewa Ayu Made Dwita