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All Journal IJCER (International Journal of Chemistry Education Research) Hydrogen: Jurnal Kependidikan Kimia
Ariyani, Helena Devi
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Chemistry Education Environmental Science Materials Science & Nanotechnology

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Alpha Amylase Inhibitory Activity of Curcumin Analogs and Its Synergy with Ferulic Acid in Vitro Nafillah, Khoirotun; Ariyani, Helena Devi; Asfirah, Lia Retian
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 3 (2025): June 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i3.15683

Abstract

Curcumin analog compounds are α,β unsaturated compounds through simplifying the beta diketo group to monoketo, which has better bioavailability and a more stable structure than curcumin compounds. This study aims to determine the α-amylase inhibitory activity on symmetric curcumin analog compounds, namely the compounds 2,6-bis(3,4-dimethoxybenzylidine)cyclohexanone (A) and 2,6-bis(3,4-dimethoxybenzylidine)cyclopentanone (B). as well as testing its synergistic interaction with ferulic acid in vitro. The α-amylase inhibition test was carried out using an iodine reagent and a starch solution as a substrate. The absorbance value was measured using a UV-vis spectrophotometer (λ 568 nm), and the % inhibition was calculated. The average value of the optimum α-amylase inhibition percentage for compounds A, B, and ferulic acid, respectively is 58.17%; 22.95%, and 93.52%. Based on the synergistic interaction, it was concluded that compounds A and B showed synergistic activity with ferulic acid. The percentage of α-amylase inhibition in the concentration ratio of curcumin analog A: ferulic acid (1:8) was 98.65%, and curcumin analog B: ferulic acid (1:4) was 98.37%. This shows that combining compounds between symmetrical curcumin analogs and ferulic acid can increase the activity of antidiabetic drug candidate compounds compared to single compounds. This study offers a new approach by testing the potential combination of curcumin and ferulic acid analogues as α-amylase inhibitors in vitro, demonstrating a synergy that has not been widely explored and opening up opportunities for developing more effective natural antidiabetic therapies.
Enhancing Students’ Learning Outcomes on Atomic and Molecular Concepts through PhET Simulations Using Build an Atom and Build a Molecule in Engineering Students Nafillah, Khoirotun; Ariyani, Helena Devi; Ekawati, Linda
IJCER (International Journal of Chemistry Education Research) VOLUME 10, ISSUE 2, OCTOBER 2026
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijcer.vol10.iss2.art2

Abstract

Atomic and molecular concepts are fundamental topics in chemistry that are often perceived as abstract and challenging, particularly for engineering students. Conventional instructional approaches that rely heavily on textual explanations and limited visualization tend to be insufficient in supporting students’ conceptual understanding. This study investigated the effectiveness of integrating the PhET interactive simulations Build an Atom and Build a Molecule into chemistry instruction in improving engineering students' learning outcomes in atomic and molecular concepts. A pre-experimental approach employing a one-group pretest–posttest design was adopted. The study involved 32 engineering students enrolled in a Basic Chemistry course. Learning outcomes were assessed using a 15-item multiple-choice test administered before and after the implementation of instruction supported by the PhET simulations Build an Atom and Build a Molecule. The collected data were analyzed using descriptive statistics, the Shapiro–Wilk normality test, the Wilcoxon Signed-Rank Test, and N-Gain analysis. Descriptive analysis revealed that the mean score increased substantially from 51.46 on the pretest to 92.08 on the posttest. The Wilcoxon Signed-Rank Test revealed a statistically significant difference between the pretest and posttest scores (p < 0.05). In addition, the average N-Gain score of 0.82 was classified as high, indicating substantial improvement in students' learning outcomes. These findings demonstrate that integrating the Build an Atom and Build a Molecule PhET simulations into chemistry instruction effectively enhances engineering students' understanding of atomic and molecular concepts and provides empirical support for the use of interactive, simulation-based learning in engineering education.
Co-Authors Asfirah, Lia Retian Ekawati, Linda Khoirotun Nafillah