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All Journal Jurnal Riset Kesehatan Media Penelitian dan Pengembangan Kesehatan
Kedaton, Rafi Andyah Arum
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Medicine & Pharmacology

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The Correlation Of Preeclampsia, Age, And Type Of Delivery In Postpartum Hemorrhage Kedaton, Rafi Andyah Arum; Ruspita, Mimi; Putri, Hanifa Andisetyana
Jurnal Riset Kesehatan Vol 12 No 2 (2023): NOVEMBER 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v12i2.10023

Abstract

The number of maternal deaths in Semarang City in 2021 was 21 cases out of 22,030 live births, or around 95.32 deaths per 100,000 live births, with the causes of death dominated by bleeding (14.29%) and hypertension (9.52%). Postpartum hemorrhage is caused by four main factors known as the 4T: tone, trauma, tissue, and thrombin. This study was conducted to determine the relationship between preeclampsia, maternal age, and type of delivery with the incidence of postpartum hemorrhage at Central General Hospital Dr. Kariadi Semarang in 2020–2022. The study was an analytic observational quantitative research with a retrospective case control study. The study was conducted in February 2023 with a total sample of 100 samples divided into case (total sampling) and control (simple random sampling) groups with a ratio of 1: 1 for each group. Statistical tests used Chi-square and odds ratio (OR) tests. The results showed that there was no relationship between preeclampsia and the incidence of postpartum hemorrhage (p-value = 0.063; OR = 0.347), there was a relationship between maternal age and the incidence of postpartum hemorrhage (p-value = 0.011; OR = 3.455), and there was a relationship between the type of delivery and postpartum hemorrhage (p-value = 0.012; OR = 2.923). The community can be expected to play an active role in integrated service post cadre activities and ante natal care assistance. Health workers and educational institutions also need to improve their knowledge and skills to form qualified health workers through certified training.
The role of serum ferritin as a biomarker of iron and inflammation in anemia: a systematic literature review Kedaton, Rafi Andyah Arum; Devi, Nabila Sinta; Kusworini, Kusworini; Wardani, Diadjeng Setya
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.4137

Abstract

Background: Anemia remains a major global health concern, particularly in low- and middle-income countries where distinguishing Iron Deficiency Anemia (IDA) from Anemia of Inflamation (AI) remains diagnostically challenging. Hemoglobin alone cannot differentiate these conditions, necessitating more specific biomarkers. Serum ferritin, the primary iron-storage protein, reflects body iron reserves but is also elevated during inflammation through interleukin-6-mediated hepcidin induction. Objective: This review examines the dual role of ferritin as an iron biomarker and an inflammatory marker. Methods: A literature search was conducted in PubMed, ScienceDirect, SpringerLink, and the Cochrane Library with a ten-year publication limit. Of the 89 articles identified, only eight studies met the inclusion criteria and directly evaluated the relationship between ferritin, iron status, and inflammatory processes. Results: Ferritin remains a key indicator of iron reserves, but its interpretation needs to take into account the inflammatory status. Conclusion: The combination of ferritin with inflammatory biomarkers such as C-Reactive Protein (CRP)and Alpha-1-acid glycoprotein (AGP) improves the diagnostic accuracy for anemia related to both iron deficiency and inflammation.
Co-Authors Devi, Nabila Sinta Diadjeng Setya Wardani Kusworini Handono Putri, Hanifa Andisetyana Ruspita, Mimi