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All Journal Farmaka JPSCR : Journal of Pharmaceutical Science and Clinical Research Indonesian Journal of Chemical Science
Anandawijaya, Spica Diani
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Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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In Silico Test of Active Compounds of Pomegranate Fruit (Punica granatum) Against Estrogen Receptor-α for Osteoporosis Anandawijaya, Spica Diani; Latifah, Nurul; Latifah, Ifa; Nugraha, Primadini Ayesha
Indonesian Journal of Chemical Science Vol. 14 No. 1 (2025): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v14i1.8957

Abstract

Osteoporosis is a systemic bone disease characterized by decreased bone density, so bone breaks easily. In this study, the activity of the phytoestrogen compound content in pomegranates (Punica granatum) against estrogen alpha in Silico. The study aims to get new drug candidates for osteoporosis therapy. The method used is to dock the re-docking of the natural ligands of raloxifene and docking against the ligands of test compounds which are secondary metabolite compounds in pomegranates. The Gridbox used has coordinates x center : -2,079; y center : -30,746; z center : 22,813. The caffeic acid test compound has the best potential binding to the alpha estrogen receptor.
REVIEW: EFEKTIVITAS KOMBINASI Andrographis paniculata DENGAN TANAMAN HERBAL LAIN DALAM PENANGANAN PENYAKIT DIABETES MELLITUS TIPE 2 BERDASARKAN UJI IN VIVO Anandawijaya, Spica Diani; Indradi, Raden Bayu
Farmaka Vol 23, No 3 (2025): Farmaka (November) (In Press)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v23i3.66063

Abstract

Diabetes mellitus menjadi penyakit kronis yang umum dijumpai di masyarakat, terutama diabetes mellitus tipe 2 (DMT2). DMT2 dikarakterisasi dengan defisiensi insulin akibat ketidakmampuan tubuh dalam kompensasi kebutuhan insulin karena defisiensi insulin. Saat ini pengobatan terfokus pada obat-obatan sintetis, yang diketahui memberikan efek samping berbahaya terutama untuk penggunaan jangka panjang. Oleh karena itu, eksplorasi terkait potensi komponen zat aktif tanaman terhadap aktivitas antidiabetes menjadi suatu ketertarikan. Salah satunya adalah Andrographis paniculata yang juga dikenal sebagai sambiloto. Kombinasi A. paniculata dengan tanaman herbal lain diketahui memiliki efek penurunan glukosa darah lebih baik dibandingkan dengan ekstrak tunggal A. paniculata. Artikel ini dibuat untuk meninjau aktivitas antidiabetes kombinasi A. paniculata yang dilakukan dengan uji in vivo untuk mencari kombinasi tanaman A. paniculata dan tanaman herbal lain yang optimal menurunkan kadar glukosa darah. Peninjauan komprehensif dilakukan terhadap jurnal dari database dengan kata kunci pencarian untuk artikel Bahasa Indonesia “Andrographis paniculata, Tanaman Herbal, Hiperglikemia, Diabetes Mellitus, dan In Vivo” dan untuk artikel Bahasa Inggris “Andrographis paniculata, Herbal Plant, Hyperglycemia, Diabetes Mellitus, dan In vivo”. Hasil yang diperoleh menunjukkan bahwa kombinasi ekstrak A. paniculata bersama dengan ekstrak tanaman herbal lain memberikan aktivitas antidiabetes yang lebih baik dibandingkan dengan ekstrak tunggal A. paniculata.
Formulation of Small Quantity Lipid-based Nutrient Supplement (SQ-LNS) Tablet from Soybean: A Preventive Approach on Stunted Birth for Pregnant and Breastfeeding Women Siagian, Virginia Heaven Mariboto; Cung, Johnessa; Anandawijaya, Spica Diani; Febriliani, Sandya Amelia; Widyapuspita, Avika; Sopyan, Iyan
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 2 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i2.91338

Abstract

The prevalence of stunting in Indonesia, which has not met the requirements of the WHO, makes stunting a national problem. In line with the nutritional intervention in 2020-2030, UNICEF developed SQ-LNS products as a food paste. As an effort to prevent stunting as well as improve product stability, the formulation of Small-Quantity Lipid-based Nutrient Supplements (SQ-LNS) from soybeans (Glycine max (L.) Merr) in tablet form is proposed to be a solution for pregnant and breastfeeding women. Microencapsulation technology is used to entrap soybean oil as the lipid source of this supplement. This study aims to obtain the best concentration of maltodextrin, soy protein isolate, and carboxymethyl cellulose as a soybean oil coating for felting into SQ-LNS tablet preparation. The best microcapsule is produced from a 40% formula with a percent yield of 28%, encapsulation efficiency of 79.83%, PSD microcapsule of 1.003 μm, and round agglomerated particles with a smooth surface without any residual oil seen under the SEM, and obtained the best formulation and evaluation of SQ-LNS tablets so that they meet the quality standards of good stunting supplement tablets.
Co-Authors Cung, Johnessa Febriliani, Sandya Amelia Indradi, Raden Bayu Iyan Sopyan Latifah, Ifa Nugraha, Primadini Ayesha nurul latifah Siagian, Virginia Heaven Mariboto Widyapuspita, Avika