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All Journal Indonesian Journal of Applied Research (IJAR) InaBHS (Indonesian Journal of Biomedicine and Health Science)
Putri, Inayati Diana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Medicine & Pharmacology Public Health

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Antibacterial Activity of Ethyl Acetat Fraction of Basil Leave (Ocimum Basilicum L) Toward Escherichia Coli Growth Marfuati, Sri; Weni, Mustika; Putri, Inayati Diana
Indonesian Journal of Applied Research (IJAR) Vol. 5 No. 1 (2024): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v5i1.433

Abstract

Antibiotic resistance to Escherichia coli is commonly found. Several studies have found that basil leaves contain chemical compounds: flavonoids, alkaloids, tannins, and saponins, which act as antibacterials. This research aimed to determine the inhibitory power of the ethyl acetate fraction of basil leaves (Ocimum basilicum L) on the growth of Escherichia coli. This study used a post-test-only control group design. This study contained five groups: one positive control group, one negative control group, and three treatment groups. The treatment group consisted of the ethyl acetate fraction of basil leaves at 12.5% μ, 25% μ, and 50% μ. The control group was a positive control K(+) with co-trimoxazole and a negative control K(-) with 10% Dimethyl Sulfoxide (DMSO). Kruskal walls test was chosen, followed by the Mann-Whitney difference test. In the Kruskal Walls test, a significant difference was found (p-value < 0.050) for basil leaf ethyl acetate fraction treatment. The largest average was obtained, namely the ethyl acetate fraction with a concentration of 12.5%. The Mann-Whitney test was carried out to determine fundamental differences between groups. The results of ethyl acetate fraction showed that the Minimum inhibitory concentration (MIC) for Escherichia coli was 12.5%.
UJI AKTIVITAS ANTIBAKTERI FRAKSI ETIL ASETAT DAUN KEMANGI (Ocimum basilicum L) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli Putri, Inayati Diana; Marfuati, Sri; Weni, Mustika
InaBHS (Indonesian Journal of Biomedicine and Health Science) Vol 3 No 2 (2024): Indonesian Journal of Biomedicine and Health Science
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/inabhs.v3i2.10523

Abstract

Latar Belakang : Escherichia coli merupakan bakteri penyebab diare. Banyak yang melaporkan terjadinya resistensi antibiotik terhadap Escherichia coli. Oleh karena itu dibutuhkan alternatif pengobatan. Beberapa penelitian mengatakan Daun Kemangi mengandung zat metabolit sekunder seperti alkaloid, flavonoid, saponin dan tanin yang berfungsi sebagai antibakteri. Tujuan : Mengetahui Daya Hambat Fraksi Etil Asetat Daun Kemangi (Ocimum basilicum L) Terhadap Pertumbuhan Escherichia coli. Metode : Penelitian ini adalah penelitian eksperimental laboratorium dengan rancangan penelitian post-test only control grup design. Penelitian ini menggunakan 5 kelompok, yaitu 2 kelompok kontrol dan 3 kelompok perlakuan. Kelompok perlakuan terdiri dari fraksi etil asetat dari daun kemangi konsentrasi 12,5%, 25% , 50% . Kelompok kontrol yaitu kontrol positif (K(+)) dengan cotrimoxazole dan kontrol negatif (K(-)) yaitu Dimetil Sulfoksida (DMSO) 10%. Data diuji menggunakan uji Kruskal wallis dan dilanjutkan dengan uji beda Mann Whitney Hasil : Pada uji Kruskal walls terdapat perbedaan yang signifikan (p-value < 0,050), terhadap pemberian perlakuan fraksi etil asetat daun kemangi. Didapat rerata terbesar yaitu pada fraksi etil asetat konsentrasi 12,5% 28960000000. Dilanjutkan dengan uji Mann whitney untuk mengetahui perbedaan antar kelompok, didapatkan perbedaan daya hambat pada masing-masing konsentrasi Kesimpulan : Kadar hambat minimum dari fraksi etil asetat daun kemangi terhadap pertumbuhan Escherichia coli konsentrasi 12,5% dengan nilai TPC sebesar 28960000000, dan terdapat perbedaan yang bermakna setiap konsentrasi fraksi etil asetat daun kemangi terhadap pertumbuhan Escherichia coli Kata Kunci : Daun Kemangi, Fraksi, Escherichia coli
Co-Authors Marfuati, Sri Weni, Mustika