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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia Cermin Dunia Kedokteran
Anggita, Vinka Dwi
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Agriculture, Biological Sciences & Forestry Health Professions

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Pengaruh waktu pemanasan dan pengasaman terhadap kadar albumin ekstrak ikan gabus : The effect of long heating and aciditing time on albumin levels in snakehead fish extract Yuniati, Renni; Nurtari, Rahma Yulia; Annaafi, Alviona Denti; Priguna, Tangkas Mukti; Anggita, Vinka Dwi; Kusumaningrum, Novi; Saraswati, Indah; Muslimin, Muslimin; Putra, Farmaditya Eka; Hardian, Hardian
Jurnal Pengolahan Hasil Perikanan Indonesia Vol. 27 No. 2 (2024): Jurnal Pengolahan Hasil Perikanan Indonesia 27(2)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17844/jphpi.v27i2.46448

Abstract

Snakehead fish, specifically the Channa striata species, are known to have an abundance of albumin. However, there is limited information available regarding alterations in the properties of snakehead fish extracts that have undergone high heat and acid treatment. This presents a compelling research area for further exploration and study. The aim of this study was to determine the optimal portion of the fish and to examine the effect of heating and acidification time on albumin concentration in snakehead fish. The method employed in this study involved heating samples at 70 °C for 0, 15, and 30 min and subjecting them to acidification at pH 1, 4, and 7. The extraction process was conducted using centrifugation at a speed of 6,000 rpm for 60 minutes, followed by absorbance measurement at a wavelength of 280 nm using a UV-Vis spectrophotometer to evaluate the properties of protein extracts.The relationship between albumin levels and protein levels is one of direct proportionality.According to recent studies, snakehead fish extract is a safe and effective topical treatment for skin conditions, with a pH level ranging from 4.5 to 6.5. Furthermore, snakehead meat is a rich source of albumin, containing approximately 22.4 mg of protein per 100 g. The absorbance exhibited a more substantial rise at a temperature of 70oC over a 15-minute period and in a highly acidic environment (pH 1.0). Snakehead fish protein extract is less stable and more susceptible to denaturation than standard bovine serum albumin (BSA).
Efficacy of Doxycycline Prophylaxis for Prevention of Bacterial Sexually Transmitted Infections Among People with or Without HIV: A Systematic Review and Meta-Analysis of Randomized Controlled Trials: Systematic Review Prakoeswa, Flora Ramona Sigit; Dzikri, Dykall Naf'an; Anggita, Vinka Dwi
Cermin Dunia Kedokteran Vol 53 No 09 (2026): September 2026 - CDK 356
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i09.2210

Abstract

Introduction: Bacterial sexually transmitted infections (STIs) remain a significant burden among populations at high risk, including people living with HIV (PLWH) and HIV-negative individuals receiving HIV pre-exposure prophylaxis (PrEP). This study evaluated the efficacy and safety of doxycycline pre- and post-exposure prophylaxis for preventing bacterial STIs among people with or without HIV. Methods: This systematic review followed PRISMA 2020 guidelines and was prospectively registered in PROSPERO (CRD420251171815). We conducted comprehensive searches in PubMed, Embase, and Cochrane CENTRAL through October 2025. We included randomized controlled trials evaluating doxycycline prophylaxis versus standard care. Meta-analysis was performed using random-effects models in RevMan 5.4. Results: Seven randomized controlled trials (2,091 participants) were included. Doxycycline prophylaxis significantly reduced bacterial STI incidence by 57% (pooled RR 0.43, 95% CI 0.35–0.53; p < 0.00001; I² = 42%). In the subgroup analysis of HIV-positive participants, doxycycline achieved a 62% reduction (RR 0.38; 95% CI 0.28–0.52). Pathogen-specific analysis showed a 72% reduction for chlamydia (RR 0.28), a 72% reduction for syphilis (RR 0.28), and a 44% reduction for gonorrhea (RR 0.56). Safety outcomes were summarized descriptively, with gastrointestinal symptoms most frequently reported; no pooled adverse-event or discontinuation estimate was calculated. The number needed to treat calculated from pooled event counts was approximately 4. Conclusion: Doxycycline prophylaxis reduced bacterial STI incidence in high-risk populations with and without HIV. These findings support considering doxycycline prophylaxis as a prevention strategy, while emphasizing limitations in regimen-specific evidence and the need for ongoing safety and antimicrobial-resistance monitoring.
Co-Authors Annaafi, Alviona Denti Dzikri, Dykall Naf'an Farmaditya Eka Putra Flora Ramona Sigit Prakoeswa Hardian Hardian Indah Saraswati Kusumaningrum, Novi Muslimin Muslimin Nurtari, Rahma Yulia Priguna, Tangkas Mukti Renni Yuniati