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Putra, Diky Okta Yudha
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Profil Farmakologi Binahong (Anredera cordifolia) Sebagai Kandidat Modern Medicine: Tinjauan Sistematis Fitria, Vinnie Ayu; Sakdiyah, Apriati Kalimatus; Kurniati, Veni; Putra, Diky Okta Yudha; Putri, Neviaisyah Zevani; Pratiwi, Puspa Dwi
Sinteza Vol. 5 No. 1 (2025): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i1.29368

Abstract

The pharmacological activity of Binahong has been studied for various therapeutic effects, and the plant is thought to have several bioactive compounds that contribute to its pharmacological activity. This article discusses the pharmacological profile of Anredera cordifolia as a modern medicine candidate. The use of traditional medicine utilizing this plant species has been ongoing since ancient times in Indonesia, a region blessed with abundant flora diversity. This study was examined various medical benefits of the Anredera cordifolia, particularly regarding its antioxidant, antihyperglycemic, antibacterial properties, and wound healing capabilities. The method of this systematic review used the PRISMA framework by searching scientific publications in 2020-2024 through the Crossref database. The research revealed that secondary metabolite compounds in Anredera cordifolia leaf extract include flavonoids, saponins, and phenols, which provide pharmacological effects. Antioxidant capacity measurements using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) technique yielded various IC50 values, indicated its potential as an antioxidant. Additionally, Anredera cordifolia demonstrated significant antihyperglycemic effects in animal experimental models. Its antibacterial activity against various pathogens, along with its ability to accelerate wound healing, further confirms Anredera cordifolia potential as a modern herbal medicine. The conclusion is Anredera cordifolia shows great potential for development as an effective herbal medicine in modern treatment, supporting the trend toward more natural and environmentally friendly alternative medicine.
Optimasi dan Uji Antibakteri Nanopartikel Perak dengan Bioreduktor Ekstrak Batang Anggrek Merpati (Dendrobium crumenatum Sw.) Panjaitan, Keiza Natania; Syamsurizal, Syamsurizal; Maharini, Indri; Putra, Diky Okta Yudha; Septiana, Prima
Sinteza Vol. 5 No. 1 (2025): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i1.29574

Abstract

Silver nanoparticles have demonstrated significant antibacterial efficacy against Escherichia coli and Staphylococcus aureus.  using a green synthesis method with plant extracts rich in flavonoids as bioreductor.  The pigeon orchid (Dendrobium crumenatum Sw.) is a plant with potential as a bioreductant, especially its stem, rich in flavonoid compounds. Optimizing heating temperature, extract volume, and silver nitrate concentration is essential for producing silver nanoparticles with optimal properties and enhanced antibacterial activity.  This research conducts optimization by varying the volume of pigeon orchid stem extract, heating temperature, and AgNO3 solution concentration.  The main parameter in the optimization is the Surface Plasmon Resonance (SPR) value. The characterization of silver nanoparticles includes particle size, polydispersity index, zeta potential, FTIR spectra, and antibacterial activity tests against E. coli and S. aureus. The research results show that the optimum conditions for synthesising silver nanoparticles are 1 mL of orchid stem extract, a heating temperature of 60°C, and an AgNO3 concentration of 1.629 mM..  The silver nanoparticles produced have characteristics with an SPR peak at 450 nm, a particle size of 98.267 nm, a polydispersity index of 0.2337, and a zeta potential of -21.9 mV.  Antibacterial tests showed an inhibition zone of 14,71±1,23 mm against S. aureus and 15,28±0,91 mm against E. coli.  These results prove that silver nanoparticles effectively inhibit the growth of gram-positive and gram-negative bacteria.
Co-Authors Fitria, Vinnie Ayu Kurniati, Veni Maharini, Indri Panjaitan, Keiza Natania Puspa Dwi Pratiwi Putri, Neviaisyah Zevani Sakdiyah, Apriati Kalimatus Septiana, Prima Syamsurizal - -