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Akanda, Md. Khokon Miah
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health

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From Prodrug to Multimatrix: Recent Advancement of Colon Specific Drug Delivery System Saha, Sabuj Kumar; Hasan, A.H.M. Nazmul; Anjum, Ramisa; Rimun, Shariun Nahar; Rahman, Nujhat Zayma; Akanda, Md. Khokon Miah; Buhiyan, Mohiuddin Ahmed; Islam, SM Ashraful
Sciences of Pharmacy Volume 3 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0303233

Abstract

Prevalence of colonic diseases such as inflammatory bowel disease, colorectal cancer, angiodysplasia, salmonellosis, etc, are increasing daily and are reducing the quality of life of the patients. These diseases can be difficult to treat due to their ability to alter the normal environment of the colon such as the pH, microbiota, enzymes, and more. Anatomy and physiology of the colon also pose difficulty in case of targeted drug administration. Additionally, there are variations in how each colonic disease influences the colon, making it essential to design a Colon-Specific-Drug-Delivery System (CSDDS) that would ensure proper targeting and delivery of the drugs. To reduce systemic side effects and achieve desired therapeutic effects, the dosage form should be designed in such a way that allows for direct and precise targeting of drugs into the colon, while also preventing premature gastrointestinal drug release. In this review, we discuss the conventional (for example, prodrug, CODES, pulsatile drug delivery) and novel (OPTICORE, Phloral, MMX technology, 3D bicompartmental device) approaches aimed at ensuring drug release and absorption within the colon, as well as examine the factors that affect drug delivery targeted at the colon. Despite considerable progress, significant challenges and gaps remain, including the need for a deeper understanding of colonic environmental variability, the development of advanced biocompatible materials, and the implementation of personalized treatment strategies are highly required.
Prevalence, Causes, and Management Strategies of Fungal Diseases in Northern Regions of Bangladesh Akanda, Md. Khokon Miah; Sultana, Razia; Rana, Md. Masud; Hossain, Md. Alamgir; Barik, S. M. Abdul; Islam, Md. Rafiul; Islam, Md. Nazmul; Parvez, G.M. Masud
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301191

Abstract

In Bangladesh, fungus-related skin diseases are highly prevalent. Until this result began, there was no research in Bangladesh to find the cause and management strategies for fungal infection, but there is still no complete research on it. This survey aimed to evaluate the incidence, etiology, and therapeutic alternatives for various fungal ailments in Bangladesh. The research was carried out in Rajshahi from January to June 2019 by the Pharmacy Department of Varendra University. A compilation of 489 patient data was obtained throughout the investigation using a semi-structured questionnaire. The participants' ages vary from three months to seventy years; 327 are male, and 162 are female. The most prevalent skin conditions among the patients are as follows: ringworm (11.25%), skin infections affecting the ear, nose, fingers, and uterus (11.04%), acne (8.19%), allergy (9.82%), dandruff (5.11%), dermatitis (9.00%), eczema (5.73%), and scabies (7.18%). Student individuals comprise 49.28% of the patients, day workers 16.56%, housewives 16.36%, and employed 14.31%. Patients are housed in 53.17 percent concrete houses, 26.5 percent huts, and 26.18% semi-structures. Patients wash their clothing with tap water at a rate of 52%, followed by tube well water at 21.27%, pond water at 20.45%, and river water at 5.52%. It is evident from this study that fungal diseases affect individuals of all ages, including men and women. An adverse finding of the research was that over forty percent of patients do not receive accurate instructions from their physicians, which raises the risk of drug resistance and further contamination.
Co-Authors Anjum, Ramisa Barik, S. M. Abdul Buhiyan, Mohiuddin Ahmed Hasan, A.H.M. Nazmul Islam, Md. Nazmul Islam, MD. Rafiul Islam, SM Ashraful Md. Alamgir Hossain Md. Masud Rana Parvez, G.M. Masud Rahman, Nujhat Zayma Rimun, Shariun Nahar Saha, Sabuj Kumar Sultana, Razia