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All Journal Indonesian Journal of Pharmacology and Therapy Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Endro Nugroho, Agung
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The safety of fondaparinux, enoxaparin, and unfractionated heparin in COVID-19 patients Siti Aulia Musyrifah; Endro Nugroho, Agung; Fita Rahmawati
Indonesian Journal of Pharmacology and Therapy Vol 5 No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.8481

Abstract

The coagulopathy, a hematological disorder affecting blood clotting, carries an elevated risk of thrombosis and mortality in COVID-19 patients. Fondaparinux, enoxaparin, and unfractionated heparin (UFH) are potential treatments for reducing coagulopathy in COVID-19 patients. Nonetheless, anticoagulant administration increases the risk of bleeding-related adverse effects. This study aimed to evaluate the safety profile of fondaparinux, enoxaparin, and UFH in COVID-19 patients. The safety was evaluated based on the prevalence of major and minor bleeding events from the data of medical records collected retrospectively from October 2022 to December 2021 at Kediri District Hospital. The Chi-square analysis and multiple logistic regression were employed to establish associations between variables. Out of the 315 patients who meet the inclusion criteria, 35 patients (11.1%) exhibited bleeding, 11 patients (3.5%) experienced major bleeding, while 24 patients (7.6%) encountered minor bleeding. No significantly different in bleeding events both major and minor bleeding among the groups receiving fondaparinux, enoxaparin, and UFH were observed (p> 0.05). The UFH emerged as the most common anticoagulant associated with bleeding incidents. The multivariate analysis revealed that age ≥ 60 yr and concomitant medication with ketorolac influenced bleeding incidence. The monitoring of bleeding events on the use of anticoagulants is necessary.
The Relationship Between Antihypertensives Use And Uncontrolled Blood Pressure In Chronic Kidney Disease With Routine Hemodialysis Pulungan, Yulianasari; Endro Nugroho, Agung; Pramantara, I Dewa Putu
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 12 No. 2 (2025): Jurnal Kesehatan dan Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jka.v12i2.pp142-147

Abstract

Hypertension in end-stage chronic kidney disease (CKD) patients undergoing HD is difficult to control. The aim of the study was to determine the relationship between the number of antihypertensive medications taken and the use of dialyzed antihypertensive medications on uncontrolled blood pressure in CKD patients on hemodialysis. Consecutive sampling was employed in a retrospective cohort study. Data collection for the study took place in July 2023 at Temanggung Regional Hospital. The inclusion criteria in this study were CKD patients who undergoing routine hemodialysis twice a week, aged ≥ 18 years, and without or with comorbidities. Medical records and interviews with research participants were used to gather data. Forty-eight patients with clinical outcomes of uncontrolled predialysis blood pressure and four patients with regulated predialysis blood pressure made up the 52 research subjects. The number of antihypertensive drugs used is significantly associated with uncontrolled predialysis blood pressure in CKD patients with hemodialysis using antihypertensives (p-value 0,033). The use of dialyzed antihypertensive drugs is not associated with uncontrolled predialysis blood pressure in CKD patients on hemodialysis using antihypertensives (p-value 0,115).
Co-Authors Fita Rahmawati I Dewa Putu Pramantara Pulungan, Yulianasari Siti Aulia Musyrifah