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All Journal JURNAL KIMIA SAINS DAN APLIKASI Majalah Obat Tradisional Jurnal Kreativitas PKM Jurnal Ilmiah Pharmacy Indonesian Journal of Food Technology Jurnal Farmasi Kryonaut Journal of Pharmaceutical and Sciences. Journal of Research in Pharmacy and Pharmaceutical Sciences Jurnal Pengabdian Kader Bangsa
Khrisna Pangeran
Department Of Pharmacy, Faculty Of Medicine, Universitas Pembangunan Nasional “Veteran” Jakarta, Jakarta|Universitas Pembangunan Nasional “Veteran” Jakarta|Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Antioxidant Capacity from Ethyl Acetate Fraction of Kenikir (Cosmos Caudatus K) Khrisna Pangeran; Tatang Irianti Irianti; Hari Purnomo
Majalah Obat Tradisional Vol 28, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.84604

Abstract

Antioxidant is an activity that inhibits oxidation reactions due to exposure to free radicals, the search for antioxidant compounds continues to be developed from natural sources. The purpose is to identify new sources of safe and inexpensive agents through antioxidant capacity from ethyl acetate fraction on kenikir leaves was evaluated through enzymatic and non-enzymatic in vitro models. The research began with the method of separating compounds from ethanol extracts and ethyl acetate fractions, quantification of total phenolics and flavonoids, antioxidant capacity tests with DPPH, and tyrosinase enzyme. The results of the study produced isolate E which was observed in a single stain with Rf 0,80. The compound has a typical marker worth 1734.07 cm-1 with an indication of stretching vibration movement on C-O. It has a maximum wavelength of ± 216 nm, with an abundance of 49.75% and a retention time of 27.20 minutes. TPC and TFC test results, the water fraction is the most dominant value with 0.430 mgGAE/g and 0.056 mQE/g. DPPH assay results, isolate E has an IC50 value of 162.03 ppm and a %inhibition of 12.73%. The tyrosinase inhibition test of L-DOPA substrate was resulting an IC50 value of 77.51 ppm compared to kojic acid of 16.48 ppm.
Hepatotoksisitas Isoniazid, Ibuprofen, Parasetamol, dan Amoksisilin-Klavulanat: Tinjauan Naratif Pangeran, Khrisna; Saputra, Rifaldi
Jurnal Ilmiah Pharmacy Vol 13, No 1 (2026)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v13i1.892

Abstract

Hati merupakan organ dalam tubuh manusia yang berperan dalam proses metabolisme. Oleh karena itu, potensi terjadinya kerusakan hati akibat obat (drug-induced liver injury/DILI) cukup besar akibat berbagai obat dan zat kimia lingkungan yang masuk ke dalam tubuh dan dapat menyebabkan gangguan metabolisme serta homeostasis sistemik. Beberapa studi ilmiah dan klinis telah mengidentifikasi beberapa faktor terkait obat dan herbal yang berkaitan dengan peningkatan risiko kerusakan hati akibat obat. Hepatotoksisitas akibat obat merupakan penyebab utama sebagian besar kasus gagal hati dan transplantasi hati sejauh ini. Salah satu obat yang terbukti menyebabkan hepatotoksisitas pada manusia adalah isoniazid atau isonikotinil hidrazida (INH). Penelitian ini bertujuan untuk mengetahui mekanisme hepatotoksisitas yang disebabkan oleh obat-obatan seperti isoniazid, ibuprofen, amoksisilin-klavulanat, dan parasetamol. Penelitian ini merupakan analisis deskriptif kualitatif dengan sumber data berupa tinjauan pustaka yang komprehensif dan mendalam. Hasil penelitian menunjukkan bahwa INH, parasetamol, dan amoksisilin-klavulanat memiliki efek hepatotoksik yang sama, yaitu penurunan kadar GSH di hati. Sementara itu, INH dan ibuprofen mempunyai efek toksik yang mempengaruhi terjadinya apoptosis atau kematian sel nekrotik
Kegiatan Edukasi Karakteristik Pengguna Narkoba di Lingkungan Pondok Pesantren Manaratul Islam Jakarta Selatan Sebagai Upaya Mewujudkan Generasi Bebas Narkoba Fransiskus Samuel Renaldi; Khrisna Pangeran
JURNAL PENGABDIAN KADER BANGSA Vol 2 No 1 (2026): Jurnal Pengabdian Kader Bangsa
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Kader Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54816/jpkb.v2i1.1193

Abstract

This study explores the role of Manaratul Islam Islamic Boarding School in South Jakarta in preventing drug abuse among its students. The increasing prevalence of drug abuse among adolescents has raised concerns about their well-being and future. Educational institutions, including Islamic boarding schools, play a crucial role in addressing this issue. The purpose of this study was to investigate how Islamic boarding schools implement drug prevention programs and their impact on students' knowledge, attitudes, and behaviors regarding drugs. Usinga case study design with a mixed methods approach, data was collected through semi- structured interviews and Focus Group Discussions(FGDs) with students, program facilitators, and community leaders. Findings indicate that the intervention resulted in a significant increase instudents' understanding of drug abuse, confirming the effectiveness of the combination of education, peer support systems, and community engagement. This study highlights the importance of religious and educational institutions in shaping a drug- free generation and recommendsthat similar programs be implemented across other Islamic boarding schools to increase awareness and prevent drug abuse more widely.
Chemical Composition, Physicochemical, and Pharmacokinetics Profile of Custard Apple Leaf (Annona squamosa) Essential Oil Extract Khrisna Pangeran; Khairul Anam; Dewi Kusrini
Jurnal Kimia Sains dan Aplikasi Vol 28, No 8 (2025): Volume 28 Issue 8 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.8.442-451

Abstract

This study investigates the effects of different drying methods on the chemical composition, physicochemical characteristics, and pharmacokinetic properties of custard apple (Annona squamosa) leaf essential oils. The research also evaluates how these drying techniques influence the yield and quality of the oils, with particular emphasis on terpenoid content and their pharmacological relevance. Fresh custard apple leaves were subjected to four drying methods: shade drying, sun drying, oven drying at 45°C, and air conditioning (AC) drying at 20°C. Essential oils were extracted through steam distillation and analyzed using GC–MS to determine their chemical constituents. Various physicochemical parameters, including refractive index, specific gravity, acid value, and saponification value, were measured. Pharmacokinetic properties were assessed using the pkCSM online tool, while network visualization was performed via STRING.db. The drying methods significantly affected the essential oil yield, with oven drying producing the highest yield. Based on physicochemical analysis, shade drying resulted in the highest acid and ester values. The chemical profiles varied across treatments, with trans-β-caryophyllene, germacrene D, and α-humulene identified as the dominant compounds in all samples. Network pharmacology analysis indicated that CYP2C9 and CYP2C19 play critical roles in optimizing personalized therapy by minimizing adverse effects and enhancing drug efficacy across various diseases.
PHYTOCHEMICAL SCREENING OF PULAI STEM BARK (Alstonia scholaris (L.) R. Br) METHANOL EXTRACT USING ULTRASONIC ASSISTED EXTRACTION METHOD Arini Nur Yunia Puspitaningrum Rahmawati; Prisnu Tirtanirmala; Khrisna Pangeran
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 4 No 2 (2025): Vol.4 No.2 DECEMBER (2025)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v4i2.13038

Abstract

This study aimed to characterize the secondary metabolite content of Pulai (Alstonia scholaris (L.) R. Br) stem bark through preliminary phytochemical screening of its methanol extract obtained using ultrasound-assisted extraction (UAE). The research is significant as it provides basic phytochemical information to support the ethnomedicinal use of Alstonia scholaris and to explore its potential as a natural source of bioactive compounds for future phytopharmaceutical development. Dried stem bark from Central Borneo was extracted with methanol using UAE at room temperature with a simplicia-to-solvent ratio of 1:5 and three remaceration cycles, yielding 5.29% w/w crude extract with a yellowish-black appearance. Phytochemical screening was carried out using specific qualitative tests for alkaloids (Mayer, Dragendorff, Bouchardat), flavonoids (Shinoda), phenolics (FeCl₃), saponins (foam test), and steroids/terpenoids (Liebermann–Burchard). The methanol extract tested positive for alkaloids and terpenoids, while flavonoids, saponins, and steroids were not detected. These findings indicate that alkaloids and terpenoids are the dominant secondary metabolites in the methanol extract of Alstonia scholaris stem bark obtained by UAE, and provide a foundational profile for further studies on its biological activities.
A SYSTEMATIC REVIEW OF THE USE OF ARTIFICIAL INTELLIGENCE (VOICE ASSISTANCE) TO IMPROVE MEDICATION COMPLIANCE IN BLIND PATIENTS WITH TUBERCULOSIS Renaldi, Fransiskus Samuel; Pangeran, Khrisna
Jurnal Farmasi Kryonaut Vol 5 No 2 (2026): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v5i2.196

Abstract

Tuberculosis remains a major infectious disease worldwide, with medication non-adherence a critical barrier to successful treatment. Patients with visual impairments face additional challenges in medication management due to their inability to read medication labels, increasing the risk of medication errors and non-adherence. This systematic review analyzed 23 studies on the application of artificial intelligence (AI) to improve medication adherence in tuberculosis (TB) patients, with a particular focus on the potential of AI voice assistance for visually impaired patients. Results showed that AI such as machine learning (ML), natural language processing (NLP), and computer vision effectively improved the accuracy of drug resistance prediction (>90%) and adherence by up to 32%, although challenges such as algorithm bias, data privacy, and geographic accessibility remained significant. For visually impaired TB patients, voice technologies such as Google Assistant or Alexa offer non-visual solutions through personalized reminders, text-to-speech pill recognition (85-95% accuracy), and intake confirmation, overcoming the limitations of visual-dependent video-observed therapy (VDOT). Integrating voice AI with digital therapies (DTx) has the potential to improve autonomy and clinical outcomes in resource-limited settings, but requires empirical randomized controlled trials (RCTs) and user training. This study recommends the development of a culturally based hybrid voice therapy-VDOT for Indonesia
Pelayanan Farmasi untuk Daerah Tertinggal, Terdepan, dan Terluar (3T) Terkait Program Penyakit HIV Berdasarkan Integrasi Model Pemberi Layanan yang Terdiferensiasi (PLD): Sebuah Tinjauan Sistematis Fransiskus Samuel Renaldi; Khrisna Pangeran
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1331

Abstract

Background: Differentiated Service Delivery (DSD) has been proposed to improve HIV treatment continuity in remote areas; however, its success depends on the integration of systemic supports. Objective: This review synthesizes evidence on the effectiveness of community-based DSD models and the determinants of their success in underdeveloped, frontier, and outermost (3T) areas, particularly concerning supply chain resilience, quality assurance, and aligned governance and financing. Methods: A systematic review with narrative synthesis was conducted following PRISMA guidelines. Literature searches were performed in PubMed, Scopus, Web of Science, and grey literature repositories (2010–2025). Out of 1,520 records, 32 studies met the inclusion criteria. Results: Community-based DSD models (ART groups, MMD) were effective in improving adherence, retention, and reducing visit burden. This success was strongly determined by: (1) ARV supply chain stability (minimal stock-out days, synchronization with MMD schedules); (2) quality assurance in storage–distribution (temperature control, FEFO); and (3) aligned governance and financing (pharmacist roles, community health worker incentives, last-mile funding). Qualitative findings identified service proximity, confidentiality, and logistical reliability as key facilitators. Conclusion: DSD is a systemic intervention whose effectiveness hinges on multidimensional readiness. Strengthening HIV pharmaceutical services in 3T areas requires an integrated approach that simultaneously builds supply resilience, service quality, and adaptive governance. This review proposes operational indicators and a phased implementation roadmap for contextual adaptation.
Anti-Drugs Youth Cadre Training: An Effort to Strengthen the Perception and Knowledge of Madrasah Aliyah Students in South Jakarta Fransiskus Samuel Renaldi; Khrisna Pangeran
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 9, No 9 (2026): Volume 9 Nomor 9 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v9i9.27353

Abstract

ABSTRACT Adolescent drug abuse is a public health concern influenced by access to substances, peer pressure, and exposure to digital information. This activity aimed to describe Madrasah Aliyah Mannaratul Islam students’ perceptions and knowledge of drug-abuse risks and to assess immediate knowledge change following anti-drug youth cadre training. This community-service evaluation used a qualitative descriptive design with content analysis of verbatim interview responses from 70 students in grades 10–12, supported by univariate analysis of respondent characteristics and pretest–posttest knowledge scores. Most students perceived drugs as deadly and addictive (80%); 93% lived in a complete family structure, and 26% had received counseling during the previous six months. Knowledge scores increased from 87.5% to 96.0% after the educational session. The findings indicate that knowledge improvement should be reinforced through interactive education, digital literacy, stronger family communication, and peer-led intervention grounded in madrasa values. Keywords: Drug Perception, Adolescent Knowledge, Madrasa Prevention, Drug Education.
The Physical Evaluation and Hedonic Comparison of Aloe Vera (Aloe vera (L.) Burm.f.) Gel Soaked in Rice-Washing Water and Lime Water Arini Nur Yunia Puspitaningrum Rahmawati; Andiri Niza Syarifah; Rifaldi Saputra; Khrisna Pangeran; Annisa Farida Muti
Indonesian Journal of Food Technology Vol 5 No 2 (2026): Indonesian Journal of Food Technology
Publisher : Program Studi Teknologi Pangan Fakultas Pertanian UNSOED

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.ijft.2026.5.2.19537

Abstract

Background: Aloe vera is widely used in food, nutraceutical, and pharmaceutical products. However, its utilization is limited by undesirable sensory characteristics, such as bitterness, excessive mucilage, and an unpleasant aroma, which reduce consumer acceptance. Pretreatment through soaking is commonly applied to improve these characteristics. Purpose: This study aimed to compare the sensory properties of aloe vera gel soaked in lime water and rice-washing water as alternative pretreatment media, with a focus on key sensory attributes related to consumer preference. Method: The study employed an experimental sensory evaluation design using a hedonic test. Fresh aloe vera gel was prepared and soaked in two different media: lime water and rice-washing water. Sensory evaluation was conducted by panelists using a five-point hedonic scale to assess color, aroma, taste, texture, and overall acceptance. The collected data were summarized as mean scores and analyzed using paired statistical comparison to evaluate differences between the two treatments. Result: The results demonstrated that both soaking treatments produced a comparable sensory profile. Color scores were identical for both treatments. Aroma and taste scores showed only minor numerical differences, suggesting a comparable level of sensory perception. Texture exhibited the largest difference. Overall sensory acceptance showed similar results between the two treatments. Overall hedonic scores indicated that aloe vera soaked in rice washing water achieved sensory acceptance comparable to lime water. These findings suggest that rice washing water was effective in reducing undesirable sensory characteristics, such as excessive mucilage and bitterness to an acceptance level.
Co-Authors Andiri Niza Syarifah Annisa Farida Muti Dewi Kusrini Hari Purnomo Khairul Anam Prisnu Tirtanirmala Rahmawati, Arini Nur Yunia Puspitaningrum Renaldi, Fransiskus Samuel Rifaldi Saputra Saputra, Rifaldi Tatang Irianti