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All Journal JURNAL KIMIA SAINS DAN APLIKASI Majalah Obat Tradisional Jurnal Ilmiah Pharmacy Journal of Pharmaceutical and Sciences.
Khrisna Pangeran
Magister Of Pharmaceutical Science, Faculty Of Phramacy, Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Antioxidant Capacity from Ethyl Acetate Fraction of Kenikir (Cosmos Caudatus K) Khrisna Pangeran; Tatang Irianti Irianti; Hari Purnomo
Majalah Obat Tradisional Vol 28, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.84604

Abstract

Antioxidant is an activity that inhibits oxidation reactions due to exposure to free radicals, the search for antioxidant compounds continues to be developed from natural sources. The purpose is to identify new sources of safe and inexpensive agents through antioxidant capacity from ethyl acetate fraction on kenikir leaves was evaluated through enzymatic and non-enzymatic in vitro models. The research began with the method of separating compounds from ethanol extracts and ethyl acetate fractions, quantification of total phenolics and flavonoids, antioxidant capacity tests with DPPH, and tyrosinase enzyme. The results of the study produced isolate E which was observed in a single stain with Rf 0,80. The compound has a typical marker worth 1734.07 cm-1 with an indication of stretching vibration movement on C-O. It has a maximum wavelength of ± 216 nm, with an abundance of 49.75% and a retention time of 27.20 minutes. TPC and TFC test results, the water fraction is the most dominant value with 0.430 mgGAE/g and 0.056 mQE/g. DPPH assay results, isolate E has an IC50 value of 162.03 ppm and a %inhibition of 12.73%. The tyrosinase inhibition test of L-DOPA substrate was resulting an IC50 value of 77.51 ppm compared to kojic acid of 16.48 ppm.
Chemical Composition, Physicochemical, and Pharmacokinetics Profile of Custard Apple Leaf (Annona squamosa) Essential Oil Extract Pangeran, Khrisna; Anam, Khairul; Kusrini, Dewi
Jurnal Kimia Sains dan Aplikasi Vol 28, No 8 (2025): Volume 28 Issue 8 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.8.442-451

Abstract

This study investigates the effects of different drying methods on the chemical composition, physicochemical characteristics, and pharmacokinetic properties of custard apple (Annona squamosa) leaf essential oils. The research also evaluates how these drying techniques influence the yield and quality of the oils, with particular emphasis on terpenoid content and their pharmacological relevance. Fresh custard apple leaves were subjected to four drying methods: shade drying, sun drying, oven drying at 45°C, and air conditioning (AC) drying at 20°C. Essential oils were extracted through steam distillation and analyzed using GC–MS to determine their chemical constituents. Various physicochemical parameters, including refractive index, specific gravity, acid value, and saponification value, were measured. Pharmacokinetic properties were assessed using the pkCSM online tool, while network visualization was performed via STRING.db. The drying methods significantly affected the essential oil yield, with oven drying producing the highest yield. Based on physicochemical analysis, shade drying resulted in the highest acid and ester values. The chemical profiles varied across treatments, with trans-β-caryophyllene, germacrene D, and α-humulene identified as the dominant compounds in all samples. Network pharmacology analysis indicated that CYP2C9 and CYP2C19 play critical roles in optimizing personalized therapy by minimizing adverse effects and enhancing drug efficacy across various diseases.
Pelayanan Farmasi untuk Daerah Tertinggal, Terdepan, dan Terluar (3T) Terkait Program Penyakit HIV Berdasarkan Integrasi Model Pemberi Layanan yang Terdiferensiasi (PLD): Sebuah Tinjauan Sistematis Renaldi, Fransiskus Samuel; Pangeran, Khrisna
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1331

Abstract

Background: Differentiated Service Delivery (DSD) has been proposed to improve HIV treatment continuity in remote areas; however, its success depends on the integration of systemic supports. Objective: This review synthesizes evidence on the effectiveness of community-based DSD models and the determinants of their success in underdeveloped, frontier, and outermost (3T) areas, particularly concerning supply chain resilience, quality assurance, and aligned governance and financing. Methods: A systematic review with narrative synthesis was conducted following PRISMA guidelines. Literature searches were performed in PubMed, Scopus, Web of Science, and grey literature repositories (2010–2025). Out of 1,520 records, 32 studies met the inclusion criteria. Results: Community-based DSD models (ART groups, MMD) were effective in improving adherence, retention, and reducing visit burden. This success was strongly determined by: (1) ARV supply chain stability (minimal stock-out days, synchronization with MMD schedules); (2) quality assurance in storage–distribution (temperature control, FEFO); and (3) aligned governance and financing (pharmacist roles, community health worker incentives, last-mile funding). Qualitative findings identified service proximity, confidentiality, and logistical reliability as key facilitators. Conclusion: DSD is a systemic intervention whose effectiveness hinges on multidimensional readiness. Strengthening HIV pharmaceutical services in 3T areas requires an integrated approach that simultaneously builds supply resilience, service quality, and adaptive governance. This review proposes operational indicators and a phased implementation roadmap for contextual adaptation.
Hepatotoksisitas Isoniazid, Ibuprofen, Parasetamol, dan Amoksisilin-Klavulanat: Tinjauan Naratif Pangeran, Khrisna; Saputra, Rifaldi
Jurnal Ilmiah Pharmacy Vol 13, No 1 (2026)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v13i1.892

Abstract

Hati merupakan organ dalam tubuh manusia yang berperan dalam proses metabolisme. Oleh karena itu, potensi terjadinya kerusakan hati akibat obat (drug-induced liver injury/DILI) cukup besar akibat berbagai obat dan zat kimia lingkungan yang masuk ke dalam tubuh dan dapat menyebabkan gangguan metabolisme serta homeostasis sistemik. Beberapa studi ilmiah dan klinis telah mengidentifikasi beberapa faktor terkait obat dan herbal yang berkaitan dengan peningkatan risiko kerusakan hati akibat obat. Hepatotoksisitas akibat obat merupakan penyebab utama sebagian besar kasus gagal hati dan transplantasi hati sejauh ini. Salah satu obat yang terbukti menyebabkan hepatotoksisitas pada manusia adalah isoniazid atau isonikotinil hidrazida (INH). Penelitian ini bertujuan untuk mengetahui mekanisme hepatotoksisitas yang disebabkan oleh obat-obatan seperti isoniazid, ibuprofen, amoksisilin-klavulanat, dan parasetamol. Penelitian ini merupakan analisis deskriptif kualitatif dengan sumber data berupa tinjauan pustaka yang komprehensif dan mendalam. Hasil penelitian menunjukkan bahwa INH, parasetamol, dan amoksisilin-klavulanat memiliki efek hepatotoksik yang sama, yaitu penurunan kadar GSH di hati. Sementara itu, INH dan ibuprofen mempunyai efek toksik yang mempengaruhi terjadinya apoptosis atau kematian sel nekrotik
Co-Authors Anam, M. Khairul Dewi Kusrini Hari Purnomo Renaldi, Fransiskus Samuel Saputra, Rifaldi Tatang Irianti