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All Journal International Journal of Health, Engineering and Technology Medical and Health Journal
Amanah Sekar Kinasih
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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HUBUNGAN KADAR TRIGLISERIDA DENGAN KEJADIAN RETINOPATI DIABETIKA PADA PASIEN DIABETES MELITUS TIPE 2 Amanah Sekar Kinasih; Dwi Arini Ernawati; Muhamad Rifqy Setyanto
Medical and Health Journal Vol 2 No 1 (2022): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (222.01 KB) | DOI: 10.20884/1.mhj.2022.2.1.7561

Abstract

Retinopati diabetika merupakan bentuk komplikasi mikrovaskular dari Diabetes Melitus tipe 2. Retinopati diabetika merupakan penyebab gangguan penglihatan terbanyak kelima di dunia. Faktor risiko yang berpengaruh pada timbulnya retinopati diabetika adalah kadar trigliserida. Diabetes Melitus tipe 2 menempati urutan keempat sebagai penyakit dengan pasien terbanyak di Fasilitas Kesehatan Tingkat Pertama (FKTP) Klinik Tanjung Purwokerto. Tujuan penelitian ini untuk mengetahui hubungan antara kadar trigliserida dengan kejadian retinopati diabetika pada pasien Diabetes Melitus tipe II di Fasilitas Kesehatan Tingkat Pertama (FKTP) Klinik Tanjung Purwokerto. Metode penelitian menggunakan metode analitik observasional dengan study cross-sectional. Jumlah sampel pada penelitian ini adalah 34 pasien Diabetes Melitus tipe 2 di PROLANIS FKTP Klinik Tanjung, pengambilan sampel menggunakan metode Consecutive Sampling. Data kadar trigliserida diambil dari pemeriksaan laboratorium darah. Data retinopati diabetika diambil berdasarkan diagnosis dokter spesialis mata. Analisis hipotesis menggunakan Chi Square 2x2. Hasil analisis bivariat antara kadar trigliserida dengan kejadian retinopati diabetika menggunakan Chi-Square 2x2 menunjukan p value : 0,09 . Hal tersebut menunjukan tidak ada hubungan bermakna antara kadar trigliserida dengan kejadian retinopati diabetika (p>0,05). Tidak terdapat hubungan bermakna antara kadar trigliserida dengan kejadian retinopati diabetika di Fasilitas Kesehatan Tingkat Pertama (FKTP) Tanjung Purwokerto.
Inotrope Use and the Risk of Intraventricular Hemorrhage in Preterm Neonates: A Systematic Review and Meta Analysis Anggita Dian Karera; Delta Iswara; Amanah Sekar Kinasih; Dyah Ati Sayuka; Din Alfina
International Journal of Health Engineering and Technology Vol. 4 No. 4 (2025): IJHET NOVEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

More than 40% of neonatal hypotension cases are managed with inotropes; however, recent evidence indicates that inotrope administration, rather than hypotension itself, is independently associated with an increased risk of intraventricular hemorrhage (IVH) after adjustment for confounding factors. This systematic review and meta-analysis aimed to evaluate the association between inotrope use and the occurrence of IVH among preterm neonates. The study followed PRISMA guidelines. A systematic literature search was conducted through PubMed, Scopus, ScienceDirect, and Google Scholar. The methodological quality of each study was assessed using the Newcastle-Ottawa Scale (NOS) for case-control and cohort designs. Relevant data were extracted for qualitative and quantitative synthesis. Meta-analysis was performed using a random-effects model based on adjusted odds ratios (aORs) reported in each study, and the results were presented as pooled aORs with 95% confidence intervals. Eight studies met the inclusion criteria. The meta-analysis showed that inotrope use was significantly associated with a higher risk of IVH in preterm neonates, including IVH of any grade (pooled OR 2.03, 95% CI 1.25-3.29) and severe IVH (pooled OR 2.00, 95% CI 1.33-3.02). Overall, inotrope use doubled the risk of IVH (pooled OR 2.00, 95% CI 1.48-2.70). These findings emphasize the need for cautious and strictly indicated inotrope administration along with standardized hemodynamic management.
Co-Authors Anggita Dian Karera Delta Iswara Din Alfina Dwi Arini Ernawati Dyah Ati Sayuka Muhamad Rifqy Setyanto