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All Journal Nursing Care and Health Technology Journal (NCHAT) International Journal of Health, Engineering and Technology
Delta Iswara
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Inotrope Use and the Risk of Intraventricular Hemorrhage in Preterm Neonates: A Systematic Review and Meta Analysis Anggita Dian Karera; Delta Iswara; Amanah Sekar Kinasih; Dyah Ati Sayuka; Din Alfina
International Journal of Health Engineering and Technology Vol. 4 No. 4 (2025): IJHET NOVEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

More than 40% of neonatal hypotension cases are managed with inotropes; however, recent evidence indicates that inotrope administration, rather than hypotension itself, is independently associated with an increased risk of intraventricular hemorrhage (IVH) after adjustment for confounding factors. This systematic review and meta-analysis aimed to evaluate the association between inotrope use and the occurrence of IVH among preterm neonates. The study followed PRISMA guidelines. A systematic literature search was conducted through PubMed, Scopus, ScienceDirect, and Google Scholar. The methodological quality of each study was assessed using the Newcastle-Ottawa Scale (NOS) for case-control and cohort designs. Relevant data were extracted for qualitative and quantitative synthesis. Meta-analysis was performed using a random-effects model based on adjusted odds ratios (aORs) reported in each study, and the results were presented as pooled aORs with 95% confidence intervals. Eight studies met the inclusion criteria. The meta-analysis showed that inotrope use was significantly associated with a higher risk of IVH in preterm neonates, including IVH of any grade (pooled OR 2.03, 95% CI 1.25-3.29) and severe IVH (pooled OR 2.00, 95% CI 1.33-3.02). Overall, inotrope use doubled the risk of IVH (pooled OR 2.00, 95% CI 1.48-2.70). These findings emphasize the need for cautious and strictly indicated inotrope administration along with standardized hemodynamic management.
Neonatal Dengue: A Case Series of Three Patients with a Wide Clinical Spectrum Anggita Dian Karera; Hana Amelia; Delta Iswara; Din Alfina
International Journal of Health Engineering and Technology Vol. 4 No. 4 (2025): IJHET NOVEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

Neonatal dengue is an uncommon but clinically important condition that can present with a wide range of symptoms. This report describes three neonatal dengue cases with distinct clinical manifestations and emphasizes the importance of early recognition. The objective of this case series is to outline the clinical features, laboratory findings, and treatment outcomes of the affected neonates. All three patients presented with fever accompanied by various symptoms, including seizures, jaundice, respiratory distress, and significant thrombocytopenia. Diagnostic evaluation consisted of serological testing, hematological assessment, and imaging studies when needed. The lowest platelet counts ranged from 10,000 to 14,000 per microliter, although none of the neonates experienced major bleeding or shock. All patients received supportive treatment, including fluid management, monitoring, and therapy tailored to presenting symptoms. Each neonate demonstrated gradual improvement and was discharged in stable condition following appropriate observation. These cases highlight that neonatal dengue may resemble sepsis and thus requires a high level of diagnostic vigilance, particularly in endemic areas or when maternal dengue is suspected. Early serological testing in both mother and infant is valuable for timely diagnosis. Supportive care and close monitoring contribute significantly to preventing complications and achieving favorable outcomes.
Korelasi Antara Strategi Koping dengan Burnout Pada Mahasiswa Kedokteran Tahun Pertama di Fakultas Kedokteran Universitas Jenderal Soedirman Delta Iswara; Ashlabiellah Nur Safah Lubis; Azmi Indria Larasati; Raditya Bagas Wicaksono
Nursing Care and Health Technology Journal (NCHAT) Vol. 6 No. 1 (2026): Nursing and Health Care Technology-January to June Period
Publisher : Progres Ilmiah Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56742/nchat.v6i1.260

Abstract

Burnout merupakan masalah psikologis yang banyak dialami mahasiswa kedokteran, terutama pada tahun pertama ketika mereka menghadapi transisi akademik yang menuntut. Strategi koping yang tepat diperlukan untuk membantu mahasiswa mengelola stres dan mencegah terjadinya burnout. Penelitian ini bertujuan untuk menganalisis hubungan antara strategi koping dan burnout pada mahasiswa kedokteran tahun pertama. Penelitian menggunakan desain cross-sectional dan melibatkan 107 mahasiswa melalui teknik total sampling. Data dikumpulkan menggunakan kuesioner Ways of Coping (WOC) dan Maslach Burnout Inventory–Student Survey (MBI-SS), kemudian dianalisis dengan uji korelasi Spearman menggunakan SPSS. Hasil penelitian menunjukkan adanya hubungan negatif yang signifikan antara strategi koping dan burnout (r = -0.548; p = 0.000). Semakin tinggi kemampuan koping mahasiswa, semakin rendah tingkat burnout yang dialami. Kesimpulannya, strategi koping berperan penting dalam meminimalkan burnout sehingga diperlukan intervensi dini untuk meningkatkan kemampuan koping mahasiswa tahun pertama.
Clinical Characteristics And Inflammatory Biomarkers Of Hospitalized Children With Hand, Foot, And Mouth Disease: A Case Series Anggita Dian Karera; Delta Iswara
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.709

Abstract

Hand, foot, and mouth disease (HFMD) is an acute viral infection that commonly affects young children. Although the disease is usually self-limiting, some patients require hospitalization due to decreased oral intake and dehydration. Data on the clinical and laboratory characteristics of hospitalized HFMD patients remain limited. This retrospective case series analyzed medical records of pediatric HFMD patients hospitalized at RSU An Ni'mah Wangon Banyumas from January 2024 to November 2025. Demographic characteristics, clinical manifestations, length of stay, and laboratory findings were collected. Inflammatory biomarkers including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were calculated. Data were analyzed descriptively. A total of 11 patients were included with a median age of 33 months (range 16–121 months). Most patients were younger than 36 months (63.6%), and 72.7% were female. The median length of hospital stay was 4 days (range 2–8 days). All patients presented with fever and oral lesions, while hand and foot lesions were observed in 81.8% and 90.9% of cases. Gastrointestinal symptoms were present in several patients. Laboratory findings were generally within normal ranges, with a median NLR of 2.76 and PLR of 160. One patient had dengue coinfection. Hospitalized HFMD patients commonly present with typical clinical features and favorable outcomes with supportive treatment. Inflammatory biomarkers such as NLR and PLR may reflect the inflammatory response in HFMD.
Stroke Prevention With Direct Oral Anticoagulants (Doac) Versus Warfarin In Patients With Non-Valvular Atrial Fibrillation (Nvaf): A Real-World Cohort Meta-Analysis Rizqiana Arum Sari; Habib Laksmana Prima; Delta Iswara; Faishal Hanif
International Journal of Health Engineering and Technology Vol. 5 No. 2 (2026): Vol 5. No. 2 JULY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i2.995

Abstract

Atrial fibrillation, particularly NVAF, is a major risk factor for stroke and systemic embolism, yet real-world evidence on the effectiveness and safety of DOACs versus warfarin remains limited. This systematic review and meta-analysis compared the effectiveness and safety outcomes of direct oral anticoagulants (DOACs) vs for stroke prevention in patients with NVAF. This review followed PRISMA guidelines. Cohort studies published in the past 10 years were identified from PubMed, Scopus, and Google Scholar, with study quality assessed using the Newcastle–Ottawa Scale. Pooled hazard ratios for the effectiveness and safety of DOACs versus warfarin in NVAF were calculated using a random-effects model in RevMan 5.4.1. A total of 12 studies were included in this meta-analysis. Compared with warfarin, DOACs significantly reduced the risk of stroke or systemic embolism (HR = 0.76, 95% CI: 0.67–0.87), ischemic stroke (HR = 0.70, 95% CI: 0.54–0.92), and hemorrhagic stroke (HR = 0.62, 95% CI: 0.45–0.86). All-cause mortality was numerically lower with DOACs but not statistically significant (HR = 0.82, 95% CI: 0.66–1.01). For safety outcomes, DOACs were associated with a lower risk of major bleeding (HR = 0.81, 95% CI: 0.65–1.00) and intracranial hemorrhage (HR = 0.57, 95% CI: 0.50–0.65), while gastrointestinal bleeding did not differ significantly between groups (HR = 1.09, 95% CI: 0.62–1.90). Based on real-world cohort evidence, DOACs demonstrate superior effectiveness in reducing stroke and systemic embolism and a more favorable safety profile compared with warfarin in patients with NVAF.
Co-Authors Amanah Sekar Kinasih Anggita Dian Karera Anggita Dian Karera Ashlabiellah Nur Safah Lubis Azmi Indria Larasati Din Alfina Dyah Ati Sayuka Faishal Hanif Habib Laksmana Prima Hana Amelia Raditya Bagas Wicaksono Rizqiana Arum Sari