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All Journal Journal of Natural Sciences and Mathematics Research Journal of Pharmaceutical and Sciences.
Harfiansyah, M. Deddy
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Simultaneous quantification of B-complex vitamins in tablet dosage form by ultraviolet spectrophotometry using the absorption factor method Effendy De Lux Putra; Siti Morin Sinaga; Harfiansyah, M. Deddy
Journal of Natural Sciences and Mathematics Research Vol. 11 No. 1 (2025): June
Publisher : Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/jnsmr.v11i1.26111

Abstract

A novel ultraviolet (UV) spectrophotometric method using the absorption factor approach was developed for the simultaneous quantification of B-complex vitamins (cobalamin, pyridoxine, riboflavin, nicotinamide, and thiamine) in tablet dosage forms. The analysis was carried out using methanol as the solvent, with distinct wavelengths selected for each vitamin: 361 nm for cobalamin, 291 nm for pyridoxine, 269 nm for riboflavin, 262 nm for nicotinamide, and 239 nm for thiamine. The method exhibited excellent accuracy, with recovery rates of 100.0851%, 100.3548%, 100.3322%, 100.7838%, and 100.4271% for cobalamin, pyridoxine, riboflavin, nicotinamide, and thiamine, respectively. This technique provides a simple, precise, and effective means for simultaneous quantification of B-complex vitamins in tablet formulations. The method satisfies all validation criteria and shows minimal interference from excipients, making it a reliable tool for quality control in pharmaceutical analysis.
Validasi Metode Analisis KCKT untuk Penetapan Kadar Parasetamol dalam Sediaan Tablet Generik dan Bermerek Harfiansyah, M. Deddy; Purba, Gratia Apulina Cindylawsa; Fitria, Fitria; Rambe , Ummi Khairani; Amar , Ageng Azhar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1107

Abstract

Background: Paracetamol is one of the most widely used analgesic and antipyretic drugs, and quality control of its dosage forms is crucial to ensure therapeutic effectiveness. Objective: This study aimed to validate a simple, rapid, and reliable High-Performance Liquid Chromatography (HPLC) method for the determination of paracetamol content in generic and branded tablet formulations. Methods: The chromatographic analysis was performed on a C18 column using a mobile phase of distilled water and methanol (3:1, v/v) with a flow rate of 1.0 mL.min–1, injection volume of 20 µL, and detection wavelength at 243 nm. Validation parameters including system suitability, linearity, accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ) were evaluated according to pharmacopeial guidelines. Results: The method demonstrated excellent linearity over the range of 8–12 µg.mL–1 (r = 0.9998), with LOD and LOQ values of 0.13 µg.mL–1 and 0.40 µg.mL–1, respectively. Accuracy values were 99.00% for generic and 98.86% for branded tablets, while precision showed %RSD of 0.53% and 0.68%. The paracetamol content was 101.47% and 100.20% for generic and branded formulations, respectively, meeting pharmacopeial standards (90–110%). Conclusion: The validated HPLC method proved to be accurate, precise, and sensitive for the quantitative determination of paracetamol in tablet dosage forms. This method is suitable for routine quality control and can be extended for stability or pharmacokinetic studies.
Co-Authors Amar , Ageng Azhar Effendy De Lux Putra Fitria Fitria Purba, Gratia Apulina Cindylawsa Rambe , Ummi Khairani Siti Morin Sinaga