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All Journal Journal of Natural Sciences and Mathematics Research Jurnal Indah Sains dan Klinis Journal of Pharmaceutical and Sciences. Jurnal Indah Sains dan Klinis Jurnal Pengabdian Kepada Masyarakat Bidang Kesehatan
M. Deddy Harfiansyah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Aplikasi Metode Penetapan Kadar Rutin Parasetamol PT. Kimia Farma, Tbk secara HPLC pada Sediaan Tablet Generik dan Bermerek di Medan Suprianto Suprianto; Darwin Syamsul; Muhammad Deddy Harfiansyah
Journal of Indah Science and Clinic Vol. 1 No. 1 (2020)
Publisher : LPPM STIKes Indah Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v1i1.1

Abstract

Paracetamol is a drug that is analgesic and antipyretic, which is produced as a generic or branded drug. The research objective was to determine the quality based on paracetamol levels in generic and branded tablet preparations circulating in Medan. The research used HPLC Alliance e2696 UV / Visible Detector 2489, Column µ Bondapak TMC-18: 10 µm 125A 3.9x300 mm, UV-Vis Spectrophotometer Agilent 8453. The method used was a routine assay method for paracetamol PT. Kimia Farma. The results showed that the paracetamol content in the tablet dosage was 97.05% - 106.04%, according to the Indonesian Pharmacopoeia Edition V, not less than 90% and not more than 110%.
Aplikasi Metode Penetapan Kadar Rutin Parasetamol PT. Kimia Farma, Tbk Secara HPLC pada Sediaan Tablet Generik dan Bermerek di Medan Suprianto; Darwin Syamsul; Muhammad Deddy Harfiansyah
Jurnal Indah Sains dan Klinis Vol 1 No 1 (2020): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/9abdjn64

Abstract

Paracetamol is a drug that is analgesic and antipyretic, which is produced as a generic or branded drug. The research objective was to determine the quality based on paracetamol levels in generic and branded tablet preparations circulating in Medan. The research used HPLC Alliance e2696 UV / Visible Detector 2489, Column µ Bondapak TMC-18: 10 µm 125A 3.9x300 mm, UV-Vis Spectrophotometer Agilent 8453. The method used was a routine assay method for paracetamol PT. Kimia Farma. The results showed that the paracetamol content in the tablet dosage was 97.05% - 106.04%, according to the Indonesian Pharmacopoeia Edition V, not less than 90% and not more than 110%.
Simultaneous quantification of B-complex vitamins in tablet dosage form by ultraviolet spectrophotometry using the absorption factor method Effendy De Lux Putra; Siti Morin Sinaga; Harfiansyah, M. Deddy
Journal of Natural Sciences and Mathematics Research Vol. 11 No. 1 (2025): June
Publisher : Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/jnsmr.v11i1.26111

Abstract

A novel ultraviolet (UV) spectrophotometric method using the absorption factor approach was developed for the simultaneous quantification of B-complex vitamins (cobalamin, pyridoxine, riboflavin, nicotinamide, and thiamine) in tablet dosage forms. The analysis was carried out using methanol as the solvent, with distinct wavelengths selected for each vitamin: 361 nm for cobalamin, 291 nm for pyridoxine, 269 nm for riboflavin, 262 nm for nicotinamide, and 239 nm for thiamine. The method exhibited excellent accuracy, with recovery rates of 100.0851%, 100.3548%, 100.3322%, 100.7838%, and 100.4271% for cobalamin, pyridoxine, riboflavin, nicotinamide, and thiamine, respectively. This technique provides a simple, precise, and effective means for simultaneous quantification of B-complex vitamins in tablet formulations. The method satisfies all validation criteria and shows minimal interference from excipients, making it a reliable tool for quality control in pharmaceutical analysis.
Validasi Metode Analisis KCKT untuk Penetapan Kadar Parasetamol dalam Sediaan Tablet Generik dan Bermerek Harfiansyah, M. Deddy; Purba, Gratia Apulina Cindylawsa; Fitria, Fitria; Rambe , Ummi Khairani; Amar , Ageng Azhar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1107

Abstract

Background: Paracetamol is one of the most widely used analgesic and antipyretic drugs, and quality control of its dosage forms is crucial to ensure therapeutic effectiveness. Objective: This study aimed to validate a simple, rapid, and reliable High-Performance Liquid Chromatography (HPLC) method for the determination of paracetamol content in generic and branded tablet formulations. Methods: The chromatographic analysis was performed on a C18 column using a mobile phase of distilled water and methanol (3:1, v/v) with a flow rate of 1.0 mL.min–1, injection volume of 20 µL, and detection wavelength at 243 nm. Validation parameters including system suitability, linearity, accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ) were evaluated according to pharmacopeial guidelines. Results: The method demonstrated excellent linearity over the range of 8–12 µg.mL–1 (r = 0.9998), with LOD and LOQ values of 0.13 µg.mL–1 and 0.40 µg.mL–1, respectively. Accuracy values were 99.00% for generic and 98.86% for branded tablets, while precision showed %RSD of 0.53% and 0.68%. The paracetamol content was 101.47% and 100.20% for generic and branded formulations, respectively, meeting pharmacopeial standards (90–110%). Conclusion: The validated HPLC method proved to be accurate, precise, and sensitive for the quantitative determination of paracetamol in tablet dosage forms. This method is suitable for routine quality control and can be extended for stability or pharmacokinetic studies.
PEMANFAATAN AMPAS KOPI SEBAGAI BAHAN DASAR KOSMETIK DI SMK FARMASI CUT MEUTIA Fitria Fitria; Siti Samaniyah; M. Deddy Harfiansyah; Rahmat Akbar; Nurhayati Nurhayati
JURNAL PENGABDIAN KEPADA MASYARAKAT BIDANG KESEHATAN Vol 7, No 2 (2025): OKTOBER 2025
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ampas kopi merupakan limbah organik yang dihasilkan dalam jumlah besar dari aktivitas konsumsi kopi, khususnya di daerah penghasil kopi seperti Provinsi Aceh. Ampas kopi masih mengandung senyawa bioaktif berupa kafein, polifenol, dan senyawa fenolik yang memiliki aktivitas antioksidan dan berpotensi dimanfaatkan sebagai bahan dasar kosmetik. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan siswa SMK Farmasi Cut Meutia Kota Banda Aceh dalam pemanfaatan ampas kopi sebagai bahan kosmetik sederhana yang aman dan ramah lingkungan. Metode kegiatan meliputi penyuluhan mengenai potensi bahan alam dalam kosmetik, demonstrasi pembuatan sediaan masker wajah berbasis ampas kopi, serta evaluasi pemahaman peserta. Hasil kegiatan menunjukkan adanya peningkatan pemahaman siswa mengenai pemanfaatan limbah organik dan kemampuan praktik pembuatan kosmetik sederhana. Kegiatan ini diharapkan dapat mendukung pembelajaran vokasional serta mendorong inovasi produk kosmetik berbasis bahan alam lokal.
Co-Authors Amar , Ageng Azhar Effendy De Lux Putra Fitria Fitria Fitria Nurhayati Nurhayati Purba, Gratia Apulina Cindylawsa Rahmat Akbar Rambe , Ummi Khairani Siti Morin Sinaga Siti Samaniyah Suprianto Suprianto Syamsul, Darwin