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All Journal Jurnal SOLMA Walisongo Journal of Chemistry
Faadila, Ayu
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Chemistry Other

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Pemberdayaan Komoditas Kelapa melalui Pelatihan Produksi dan Uji Mutu Virgin Coconut Oil (VCO) di SMAN 1 Kota Jambi Faadila, Ayu; Utami, Wiji; Fitria, Dori; Santini, Syarifa Aini Surnita; Aisyah, Aisyah; Siregar, Fadly Shalsabil; Primarani, Nabila Risa; Setyawati, Ria; Susanti, Try; Arfan, Arfan
Jurnal SOLMA Vol. 14 No. 3 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i3.20963

Abstract

Background: Sebanyak 14,8% masyarakat Indonesia mengalami kulit kering dan rasa gatal yang dapat memicu peradangan. Virgin Coconut Oil (VCO) berpotensi menjadi solusi alternatif karena memiliki kandungan asam laurat, tokoferol, dan fenolik yang bermanfaat untuk kesehatan. Potensi kelapa sebagai bahan baku VCO di Provinsi Jambi mencapai 116 ton, namun pemanfaatannya di bidang pendidikan masih terbatas. Pengabdian kepada masyarakat ini bertujuan sebagai bentuk pemberdayaan komoditas kelapa serta meningkatkan keterampilan siswa SMAN 1 Kota Jambi melalui pelatihan produksi dan uji mutu VCO. Metode: Kegiatan dilakukan mulai dari persiapan, implementasi, dan evaluasi. Hasil: Terlaksanakanya pengabdian ini membuat siswa, siswi dan guru SMAN 1 Kota Jambi sangat antusias. Mereka jadi lebih memahami potensi dari buah kelapa, cara mengolah buah kelapa menjadi produk VCO, serta memahami cara menganalisis mutu produk VCO yang sesuai dengan SNI 7381:2008. Kedua jenis VCO memiliki nilai pH 5 yang memenuhi standar, sedangkan densitas VCO murni 0,963 g/mL dan VCO ekstrak nanas 0,967 g/m. Kesimpulan: Kegiatan ini berhasil meningkatkan pemahaman dan keterampilan siswa dalam aspek produksi serta analisis mutu produk, sekaligus memberikan keuntungan bagi sekolah karena produk yang dihasilkan memiliki daya jual di pasaran.
MOLECULAR DOCKING AND DYNAMICS OF BIOACTIVE COMPOUNDS DERIVED FROM Sauropus androgynus AS CYCLOOXYGENASE-2 INHIBITORS Aisyah, Aisyah; Utami, Wiji; Faadila, Ayu
Walisongo Journal of Chemistry Vol. 8 No. 2 (2025): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v8i2.28912

Abstract

Inflammation is a biological response to injury that can become chronic and lead to various immunological disorders in humans. Bioactive compounds in Sauropus androgynus exhibit a broad spectrum of biological activity, including anti-inflammatory effects. This study employed a computational approach involving Lipinski’s Rule of Five, protein network analysis, molecular docking, ADMET prediction, molecular dynamics simulations, and Density Functional Theory (DFT) calculations for electronic structure elucidation. Among the tested compounds, corchoionoside C and afzelin demonstrated the strongest inhibitory potential against the COX-2 enzyme, with binding energies of −9.57 and −9.14 kcal/mol, respectively. Molecular dynamics simulations showed that the S. androgynus bioactive compound–COX-2 complexes exhibited minimal fluctuation and remained highly stable throughout the simulation, supporting their potential biological activity. DFT HOMO–LUMO analysis further indicated the capability of corchoionoside C and afzelin to interact with biological targets such as COX-2 through polar or electrostatic interactions. These findings are expected to provide a scientific foundation for the development of novel anti-inflammatory agents with promising pharmacological profiles and reduced adverse effects.
Co-Authors Aisyah Aisyah Arfan Arfan Dori Fitria Primarani, Nabila Risa Santini, Syarifa Aini Surnita Setyawati, Ria Siregar, Fadly Shalsabil Try Susanti Wiji Utami, Wiji