Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Organisms: Journal of Biosciences
Rahayu, Regita Lestari
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Effectiveness of Jatropha multifida L. Leaf Extract Gel on Incision Wound Healing in Male Mice (Mus musculus) Rudini, Mahmud; Widiani, Nurhaida; Febriyani, Uun; Rahayu, Regita Lestari
ORGANISMS: JOURNAL OF BIOSCIENCES Vol. 5 No. 2 (2025): Organisms: Journal of Biosciences
Publisher : Pusat HKI, Paten, dan Publikasi Ilmiah Universitas Islam Negeri Raden Intan Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/2yckgp97

Abstract

Jatropha multifida L. has been used as a traditional remedy for fresh wounds. Its bioactive compounds, including flavonoids, alkaloids, saponins, and tannins, are known for their potential to accelerate wound healing. Research on medicinal plants continues to advance in order to develop more practical pharmaceutical formulations. This study aimed to assess the effectiveness of Jatropha multifida L. leaf extract gel on incision wound healing in Mus musculus and to identify the optimal concentration. A laboratory experimental method with a Completely Randomized Design was used, consisting of five treatments: negative control (no gel), positive control (Bioplacenton), and extract gel concentrations of 15%, 30%, and 45%, each replicated three times using 15 male mice. Daily observations over 25 days included measurements of wound length, redness, scab formation and detachment, and overall wound closure. Data were analyzed using ANOVA to determine differences among treatment groups. One-way ANOVA results showed a significance value of < 0.05, indicating a meaningful effect on wound reduction. The 45% gel concentration demonstrated the highest effectiveness in promoting wound healing. This outcome is linked to the flavonoid content of Jatropha multifida, which supports vasodilation, collagen synthesis, and the strengthening of collagen fibers during the healing process.  
Co-Authors Febriyani, Uun Mahmud Rudini Nurhaida Widiani