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Alvi, Nurul Vadilla
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Agriculture, Biological Sciences & Forestry Chemistry Nursing Physics

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Antimalarial Activity of Ugonin J and Ugonin K Isolated from Tunjuk Langit (Helminthostachys zeylanica) Alvi, Nurul Vadilla
Photon: Jurnal Sain dan Kesehatan Vol. 16 No. 1 (2025): Journal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v16i1.9137

Abstract

Malaria is a life-threatening disease caused by Plasmodium parasites, transmitted by Anopheles mosquitoes, and remains a significant global health issue. This study aimed to identify the antimalarial activity of Ugonin K isolated from Tunjuk langit (Helminthostachys zeylanica). The in vitro antimalarial assay was conducted using the 3D7 strain of Plasmodium falciparum, which is sensitive to chloroquine, with Ugonin K concentrations ranging from 0.01 to 100 µg/mL. The parasitemia percentage was assessed at 48 hours post-treatment, and the percentage inhibition was calculated. The results showed a significant dose-dependent inhibition, with an IC₅₀ value of 0.12 µg/mL, indicating potent antimalarial activity. Ugonin K exhibited effective inhibition of parasitemia at concentrations as low as 1 µg/mL, supporting its potential as a promising antimalarial agent. This study suggests that Helminthostachys zeylanica could be a valuable source of antimalarial compounds.
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