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All Journal Inovasi Kesehatan Global Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Hanabila Putri
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Health Professions Medicine & Pharmacology Nursing Public Health

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Hubungan Konsentrasi Ekstrak Daun Puring dengan Variabilitas Parameter Bioaktivitas Haryanto Haryanto; Ainun Jariyah; Norita Norita; Nia Agustina; Rarah Maulidya Putri; Hastata Hastata; Naylha Salsabila Hs; Naylha Musdalifa Rabbani; Hanabila Putri; Husnul Khatimah; Najwa Nur Sahdrina
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1937

Abstract

The puring plant (Codiaeum variegatum), which has been known as an ornamental plant, apparently has significant therapeutic potential, supported by the presence of secondary metabolites such as flavonoids, tannins, saponins and alkaloids. Various modern studies report the biological activity of croton leaves, including anti-cholesterol, anti-hyperglycemia, antibacterial effects, and their use in biosurfactant formulations. However, studies on how varying extract concentrations influence bioactivity parameters quantitatively are still limited, especially in the context of dose-response relationships involving many biological parameters in one series of research. Therefore, this research was conducted to evaluate eight bioactivity parameters, namely PSM, SSSP, DSSP, SL, RO, SM, PSL, and ANA at croton leaf extract concentrations of 1%, 2%, and 4%. This research uses a laboratory experimental approach by extracting croton leaves through a maceration method using ethanol, then formulated in three concentration levels. Each parameter was analyzed quantitatively to observe the pattern of changes in biological response to variations in the dose administered. The results showed that most of the PSM, SSSP, DSSP, SL, and PSL parameters showed an optimum response at a concentration of 2%, which indicates that there is a most effective dose point before a decrease in activity occurs at the highest concentration. In contrast, several parameters such as RO, SM, and ANA showed a more fluctuating response, even the ANA parameter gave the highest value at a concentration of 4%, indicating that certain activities require higher compound levels to be achieved. In general, the response pattern found was not linear, but instead formed an optimum curve typical of the bioactivity of plant extracts. These findings confirm that determining dosage is very important in the use of croton leaf extract, both for pharmacological purposes and for the formulation of natural ingredient-based products.
Uji Larvasida Ekstrak Etanol 70% Daun Trembesi (Samanea Saman (Jacq.) Merr.) Berdasarkan Pendekatan Nilai LC₅₀ pada Larva Artemia Salina Leach Haryanto Haryanto; Aldya Marjanah Putri; Nia Agustina; Nur Asyah; Husnul Khatimah; Hanabila Putri; Hilyah Muthiah M. H; Femy Femy; Saskiah Adiajun; Marwah Ridwan
Inovasi Kesehatan Global Vol. 3 No. 3 (2026): Agustus: Inovasi Kesehatan Global
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/ikg.v3i3.3378

Abstract

Trembesi (Samanea saman (Jacq.) Merr.) leaves contain various secondary metabolites, including flavonoids, alkaloids, saponins, tannins, phenolic compounds, and terpenoids, which are known to possess diverse biological activities. However, information regarding the safety profile of the 70% ethanol extract of S. saman leaves remains limited. Therefore, a preliminary toxicity evaluation is necessary. This study aimed to determine the toxicity profile of the 70% ethanol extract of S. saman leaves based on the LC₅₀ value using Artemia salina Leach larvae. This laboratory experimental study employed the Brine Shrimp Lethality Test (BSLT) with a post-test only control group design. The extract was prepared by maceration using 70% ethanol and tested at concentrations of 10, 100, 500, 1,000, and 5,000 ppm. Larval mortality was observed after 24 hours of exposure, and the data were analyzed using probit analysis to determine the LC₅₀ value. The results showed that larval mortality increased with increasing extract concentration, reaching 18.92%, 52.78%, 79.55%, 91.23%, and 97.22%, respectively. Probit analysis indicated an LC₅₀ value of approximately 72.66 mg/L, classifying the extract as toxic according to the toxicity classification proposed by Haryanto et al. (2023). These findings indicate that the 70% ethanol extract of S. saman leaves exhibits significant toxicity toward Artemia salina Leach larvae and may contain bioactive compounds with potential pharmacological applications. Further toxicity and pharmacological studies are recommended to evaluate its safety and therapeutic potential and is useful as a natural pesticide.
Co-Authors Ainun Jariyah Aldya Marjanah Putri Femy Femy Haryanto Haryanto Haryanto Haryanto Hastata Hastata Hilyah Muthiah M. H Husnul Khatimah Marwah Ridwan Najwa Nur Sahdrina Naylha Musdalifa Rabbani Naylha Salsabila Hs Nia Agustina Norita Norita Nur Asyah Rarah Maulidya Putri Saskiah Adiajun