Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal International Journal of Cell and Biomedical Science
Dwi Widyawati
Department Of Physiology, Faculty Of Medicine And Health Science, Sultan Ageng Tirtayasa University, Banten 42118, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Targeting Hypoxia-Induced Oxidative Stress via Natural Antioxidant Modulation: From Cellular Signaling to Therapeutic Perspectives Dwi Widyawati; Ghea Farmaning Thias Putri; Rifdah Hanifah; Firda Asmaul Husna; Nabila Aulia Tsaqifah; Ainina Al Shadrina
International Journal of Cell and Biomedical Science Vol 4 No 12 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i12.76

Abstract

Hypoxia is a fundamental physiological and pathological condition that disrupts cellular homeostasis through the excessive generation of reactive oxygen species (ROS), leading to oxidative stress, inflammation, and organ dysfunction. The imbalance between ROS production and antioxidant defense mechanisms is a key contributor to cell injury and disease progression. This review aims to elucidate the molecular interactions among major redox-sensitive signaling pathways hypoxia-inducible factor 1 (HIF-1), nuclear factor kappa B (NF-κB), and nuclear factor erythroid 2-related factor 2 (Nrf2) in hypoxia-induced oxidative stress, and to highlight the therapeutic potential of natural antioxidants in modulating these pathways. Relevant literature published over the past five years (2020-2025) was systematically reviewed using databases including PubMed, Scopus, and ScienceDirect. The selected studies focused on molecular redox signaling, hypoxia-induced oxidative mechanisms, and the modulatory roles of natural phytochemicals such as Ficus carica bioactive compounds. Recent findings reveal that natural antioxidants regulate redox signaling by activating Nrf2-dependent antioxidant responses, suppressing NF-κB driven inflammation, and stabilizing HIF-1α under hypoxic conditions. Phytochemicals, particularly flavonoids and polyphenols, exhibit strong potential to restore oxidative balance, protect cellular integrity, and reduce hypoxia-induced damage. Modulating hypoxia-induced oxidative stress through natural antioxidant pathways offers a promising therapeutic strategy. A deeper understanding of the molecular crosstalk between redox signaling and phytochemical activity may provide new insights for developing preventive and therapeutic interventions against hypoxia-related disorders.
Biomedical Profile of Hemoglobin Level, Nutritional Status, and Blood Type in Community-Based Health Screening at Pematang Kamasan Posyandu Firda Asma’ul Husna; Ghea Farmaning Thias Putri; Dwi Widyawati; Rifdah Hanifah
International Journal of Cell and Biomedical Science Vol 5 No 13 (2026)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v5i13.94

Abstract

Background: Community-based health screening is essential for the early detection of hematological abnormalities, nutritional disorders, and limited health awareness, particularly in rural populations with restricted access to routine medical services. Objective: This study aimed to describe hemoglobin levels, body mass index (BMI) status, blood type distribution, and community health knowledge among residents participating in Posyandu-based screening in Pematang, Kamasan Village. Methods: A descriptive observational study was conducted using secondary data from community health screening. Among 143 attendees, complete biomedical and knowledge assessment data were available for 45 participants. Variables included sex, hemoglobin level, BMI category, blood type, and awareness of personal blood type and hemoglobin status. Data were analyzed descriptively using frequency distribution, percentage, and mean ± standard deviation. Results: Female participants predominated in the screened population. Blood group O was the most common type, and obesity represented the dominant BMI category. Mean hemoglobin levels in both males and females were generally within normal physiological ranges. Despite measurable biomedical parameters, most participants were unaware of their personal blood type and hemoglobin status, indicating low community health literacy. Conclusion: This study demonstrates a coexistence of relatively normal hemoglobin status with high obesity prevalence and limited biomedical awareness in a rural community. Strengthening integrated community screening combined with targeted health education is necessary to improve preventive health behavior and reduce future cardiometabolic risk.
Co-Authors Ainina Al Shadrina Firda Asma’ul Husna Ghea Farmaning Thias Putri Husna, Firda Asmaul Rifdah Hanifah Rifdah Hanifah