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All Journal Nusantara Medical Science Journal Tirtayasa Medical Journal International Journal of Cell and Biomedical Science Tirtayasa Medical Journal Jurnal Sains dan Kesehatan Masyarakat Mandiri: Jurnal Pengabdian Dan Pembangunan Lokal
Ghea Farmaning Thias Putri
Sultan Ageng Tirtayasa University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Penguatan Perilaku Hidup Sehat dan Bermoral melalui Edukasi Anti-Narkoba, Anti-Bullying, dan Anti-Korupsi Ekawati Rini Wulansari; Luluk Hermawati; Ghea Farmaning Thias Putri; Rifdah Hanifah; Ainina Al Shadrina; Dwi Widyawati
Masyarakat Mandiri : Jurnal Pengabdian dan Pembangunan Lokal Vol. 2 No. 4 (2025): Oktober: Masyarakat Mandiri : Jurnal Pengabdian dan Pembangunan Lokal
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/masyarakatmandiri.v2i4.2032

Abstract

Early character education plays a fundamental role in shaping a generation that is not only intelligent but also physically healthy, emotionally balanced, and morally responsible. The cultivation of these values from an early age is crucial to equip children with the resilience needed to face various social challenges in the future. This community service activity was designed to increase awareness among elementary school students regarding three critical issues: the dangers of drug abuse, the practices of bullying, and the detrimental impact of corruption. The program was conducted at SDN 1 Citeluk with the participation of approximately 80 students from grades IV to VI. The educational materials were delivered through an interactive approach combining lectures, group discussions, role-playing, and quizzes. This approach was selected to ensure that the learning process was enjoyable, engaging, and easily understood by children at the elementary school level. During the sessions, students were introduced to the basic concepts of drugs, their harmful effects on health and life, and the importance of avoiding them. Additionally, the program emphasized identifying the various forms of bullying—whether physical, verbal, or social—and encouraged students to develop empathy and mutual respect. Another important aspect addressed was corruption, where students were guided to recognize the value of honesty and integrity through relatable examples in daily life. The results of the activity revealed that students were able to clearly understand the dangers of drugs, recognize the different forms of bullying, and provide examples of honest and moral behavior. This indicates that early character education delivered through interactive and participatory methods can effectively enhance children’s comprehension of healthy and moral values. It is expected that similar programs can be carried out sustainably in elementary school settings as part of continuous character-building efforts to support the development of a responsible and ethical young generation
Bax/Bcl-2 Ratio as the Golden Marker of Apoptosis: Molecular Mechanisms and Regulatory Pathways Putri, Ghea Farmaning Thias; Nurfatihah Z, Zahara
International Journal of Cell and Biomedical Science Vol 4 No 10 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i10.65

Abstract

Apoptosis is an essential biological mechanism responsible for maintaining tissue homeostasis by removing unnecessary or damaged cells. Among the key molecular regulators, the interplay between the pro-apoptotic protein Bax and the anti-apoptotic protein Bcl-2 determines cellular fate. The Bax/Bcl-2 ratio has been recognized as the “golden marker” of apoptosis, representing the fine equilibrium between survival and death signaling pathways within cells. This review aims to provide an updated overview of recent advances in understanding the molecular mechanisms and regulatory networks that control the Bax/Bcl-2 ratio and its significance as a diagnostic and therapeutic biomarker. Relevant studies were systematically identified from PubMed, Scopus, ScienceDirect, and Google Scholar, focusing on publications from 2020 to 2025. Current evidence suggests that the Bax/Bcl-2 ratio is influenced by transcriptional regulation involving p53, NF-κB, and Akt/PI3K pathways, as well as by post-translational modifications such as phosphorylation and ubiquitination that govern mitochondrial membrane permeabilization. Clinically, alterations in this ratio correlate with disease progression, therapeutic response, and prognosis in cancer, neurodegenerative, and renal disorders. Targeting this ratio through modulation of upstream regulators or BH3 mimetics offers promising therapeutic potential. In conclusion, a deeper understanding of the Bax/Bcl-2 ratio provides crucial perspectives for advancing diagnostic innovation and developing targeted therapies for apoptosis-related diseases.
Maternal Obesity, Metabolic Syndrome, and Long-Term Effects on Offspring: A Developmental Origins of Health and Disease (DOHaD) Perspective Tsaqifah, Nabila Aulia; Hanifah, Rifdah; Husna, Firda Asma'ul; Hidayati, Mailani Dwi; Widyawati , Dwi; Putri, Ghea Farmaning Thias; Al Shadrina, Ainina
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.47907

Abstract

Introduction: The global prevalence of obesity among women of reproductive age has increased markedly over the past two decades, reaching 24% in high-income and 16% in low- and middle-income countries. This trend contributes to adverse maternal and neonatal outcomes, including a 2–4-fold higher risk of gestational diabetes, a threefold increase in preeclampsia, and up to a 50% higher caesarean delivery rate. Maternal metabolic disorders also have long-term consequences for offspring metabolic and cardiovascular health. Objective: To synthesize current biological and epidemiological evidence linking maternal metabolic status to offspring health within the Developmental Origins of Health and Disease (DOHaD) framework. Methods: A comprehensive search was conducted in PubMed, Scopus, and Web of Science from January 2015 to September 2025 using keywords related to maternal obesity, metabolic syndrome, DOHaD, offspring health, and epigenetics. Included studies comprised human and animal research with follow-up beyond two years, while case reports, editorials, and studies without long-term outcomes were excluded. Findings: From 22 eligible studies, consistent evidence indicates that maternal obesity and metabolic syndrome affect offspring through placental dysfunction, systemic inflammation, and epigenetic reprogramming. Offspring of obese mothers show a 1.5–2.8-fold increased risk of obesity and insulin resistance during adolescence and adulthood. Epigenome-wide analyses reveal altered methylation of genes regulating lipid metabolism (LEP, IGF2) and inflammatory pathways, supporting the DOHaD hypothesis. Conclusion: Maternal metabolic health critically shapes offspring developmental and metabolic outcomes. Preconception and antenatal interventions targeting metabolic optimization provide key opportunities to prevent intergenerational transmission of metabolic risk and promote healthier future generations.
Profil Pengetahuan Data Kesehatan Dasar: Studi Deskriptif Mengenai Golongan Darah dan Hemoglobin pada Kelompok Usia Dewasa Muda: Basic Health Data Knowledge: A Descriptive Study of Blood Groups and Hemoglobin in Young Adults Husna, Firda Asma'ul; Hermawati, Luluk; Putri, Ghea Farmaning Thias; Pratiwisitha, Maytia
Jurnal Sains dan Kesehatan Vol. 8 No. 2 (2026): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v8i2.2630

Abstract

Blood type and hemoglobin (Hb) levels constitute essential basic health data that play a critical role in health screening, emergency medical management, and individual readiness for blood donation. Among university students, the availability and understanding of these basic health data remain challenging due to suboptimal levels of knowledge and limited screening history. This study aimed to analyze students’ knowledge levels regarding blood type and hemoglobin levels as basic health data and to explore their implications for personal health awareness and potential participation as blood donors. This research employed a descriptive observational design with randome sampling involving 143 students. Data were collected using a questionnaire to assess students’ knowledge levels and screening history related to blood type and hemoglobin levels. The results showed that 28% of students were unaware of their blood type, while approximately 77% had never known their hemoglobin levels. These findings indicate limited knowledge and screening history of basic health data, rather than reflecting clinically low hemoglobin levels. Overall, approximately two-thirds of students were aware of their blood type. The low level of knowledge regarding blood type and particularly hemoglobin levels reflect insufficient health screening awareness among young adults. Inadequate monitoring of hemoglobin levels may result in undetected anemia, potentially affecting health status and academic performance. Furthermore, limited knowledge of these health parameters may reduce students’ readiness to serve as potential blood donors. The availability of students’ basic health data related to blood type and hemoglobin levels remains suboptimal, highlighting the need for continuous health education and routine health screening programs within the university setting. Keywords:          blood type; hemoglobin; knowledge; basic health data; university students   Golongan darah dan kadar hemoglobin (Hb) merupakan data kesehatan dasar yang berperan penting dalam skrining kesehatan, penanganan kegawatdaruratan medis, serta kesiapan individu sebagai pendonor darah. Pada kelompok mahasiswa, ketersediaan dan pemahaman terhadap data kesehatan dasar ini masih menjadi tantangan karena tingkat pengetahuan dan riwayat pemeriksaan yang belum optimal. Penelitian ini bertujuan untuk menganalisis tingkat pengetahuan mahasiswa mengenai golongan darah dan kadar hemoglobin sebagai data kesehatan dasar serta implikasinya terhadap kesadaran kesehatan pribadi dan potensi keterlibatan sebagai pendonor darah. Penelitian ini merupakan studi observasional deskriptif dengan random sampling yang melibatkan 143 mahasiswa Data dikumpulkan menggunakan kuesioner untuk menilai tingkat pengetahuan dan riwayat pemeriksaan golongan darah serta kadar hemoglobin. Sebanyak 28% mahasiswa belum mengetahui golongan darahnya, sementara sekitar 77% mahasiswa belum pernah mengetahui kadar hemoglobinnya. Temuan ini menunjukkan rendahnya pengetahuan dan riwayat pemeriksaan terhadap data kesehatan dasar, bukan mencerminkan kondisi klinis kadar hemoglobin yang rendah. Secara umum, sekitar dua pertiga mahasiswa telah mengetahui golongan darahnya. Rendahnya pengetahuan mahasiswa terhadap golongan darah dan terutama kadar hemoglobin mencerminkan rendahnya kesadaran skrining kesehatan pada kelompok usia dewasa muda. Kurangnya pemantauan kadar hemoglobin berpotensi menyebabkan kondisi anemia tidak terdeteksi serta berdampak pada kesehatan dan performa akademik. Selain itu, keterbatasan pengetahuan ini juga memengaruhi kesiapan mahasiswa sebagai calon pendonor darah. Ketersediaan data kesehatan dasar mahasiswa terkait golongan darah dan kadar hemoglobin masih belum optimal, sehingga diperlukan edukasi dan skrining kesehatan berkelanjutan di lingkungan perguruan tinggi. Kata Kunci:         golongan darah; hemoglobin; pengetahuan; data kesehatan dasar; mahasiswa  
Hipoksia Intermiten sebagai Pemicu Disfungsi Mitokondria: Tinjauan Naratif Mekanisme Seluler Dwi Widyawati; Ghea Farmaning Thias Putri
Tirtayasa Medical Journal Vol 5, No 2 (2026): May
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/tmj.v5i2.39071

Abstract

Intermittent hypoxia is characterized by recurrent cycles of oxygen deprivation and reoxygenation, commonly observed in chronic diseases such as obstructive sleep apnea, respiratory disorders, and metabolic conditions. Compared to continuous hypoxia, it induces more dynamic cellular stress, particularly affecting mitochondrial function. This review aimed to analyze the cellular mechanisms by which intermittent hypoxia triggers mitochondrial dysfunction. A structured narrative literature search was conducted using PubMed, Scopus, ScienceDirect, and Google Scholar. A total of 104 articles were identified, of which 22 met the inclusion criteria and were included in the analysis. Selected studies were descriptively synthesized to identify key mechanisms. Intermittent hypoxia disrupts mitochondrial electron transport chain activity, especially at complexes I and III, leading to electron leakage and increased reactive oxygen species (ROS). Recurrent oxidative stress causes mitochondrial membrane damage, protein oxidation, mitochondrial DNA injury, reduced ATP synthesis, and impaired cellular bioenergetics. It also alters mitochondrial dynamics and weakens antioxidant defenses. Intermittent hypoxia is a major trigger of mitochondrial dysfunction through repetitive oxidative stress, contributing to metabolic disturbances and organ dysfunction.
Targeting Hypoxia-Induced Oxidative Stress via Natural Antioxidant Modulation: From Cellular Signaling to Therapeutic Perspectives Dwi Widyawati; Ghea Farmaning Thias Putri; Rifdah Hanifah; Firda Asmaul Husna; Nabila Aulia Tsaqifah; Ainina Al Shadrina
International Journal of Cell and Biomedical Science Vol 4 No 12 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i12.76

Abstract

Hypoxia is a fundamental physiological and pathological condition that disrupts cellular homeostasis through the excessive generation of reactive oxygen species (ROS), leading to oxidative stress, inflammation, and organ dysfunction. The imbalance between ROS production and antioxidant defense mechanisms is a key contributor to cell injury and disease progression. This review aims to elucidate the molecular interactions among major redox-sensitive signaling pathways hypoxia-inducible factor 1 (HIF-1), nuclear factor kappa B (NF-κB), and nuclear factor erythroid 2-related factor 2 (Nrf2) in hypoxia-induced oxidative stress, and to highlight the therapeutic potential of natural antioxidants in modulating these pathways. Relevant literature published over the past five years (2020-2025) was systematically reviewed using databases including PubMed, Scopus, and ScienceDirect. The selected studies focused on molecular redox signaling, hypoxia-induced oxidative mechanisms, and the modulatory roles of natural phytochemicals such as Ficus carica bioactive compounds. Recent findings reveal that natural antioxidants regulate redox signaling by activating Nrf2-dependent antioxidant responses, suppressing NF-κB driven inflammation, and stabilizing HIF-1α under hypoxic conditions. Phytochemicals, particularly flavonoids and polyphenols, exhibit strong potential to restore oxidative balance, protect cellular integrity, and reduce hypoxia-induced damage. Modulating hypoxia-induced oxidative stress through natural antioxidant pathways offers a promising therapeutic strategy. A deeper understanding of the molecular crosstalk between redox signaling and phytochemical activity may provide new insights for developing preventive and therapeutic interventions against hypoxia-related disorders.
Preliminary Study on Long Fixation in Histological Preparations of Internal Organs of Sprague Dawley Rats Galang Prahanarendra; Devy Ariany; Nurlaely Mida Rachmawati; Luluk Hermawati; Ghea Farmaning Thias Putri
International Journal of Cell and Biomedical Science Vol 4 No 12 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i12.77

Abstract

Histotechnology is a series of processes ranging from tissue handling to the preparation of slides that can be observed under a microscope. One crucial stage in this process is fixation, which serves to preserve the structure and morphology of the tissue as close as possible to its original physiological state. However, prolonged fixation duration may lead to tissue hardening, dissolution, and structural damage. This study aims to obtain supporting data for the development of a standard operating procedure (SOP) in histotechnology that can be applied in the animal house and histology laboratories of the Faculty of Medicine, Syarif Hidayatullah State Islamic University Jakarta. The results showed that fixation for three weeks caused morphological damage to the kidney, liver, and pancreas of Sprague Dawley rats. The findings included tissue perforation in all three organs, endothelial nuclear damage in the kidney, central vein wall damage in the liver, and cellular disintegration in the pancreatic islets of Langerhans. Based on these findings, it can be concluded that a fixation duration of three weeks does not produce optimal histological images and therefore cannot be used as a reference for establishing a standard histotechnology SOP in the laboratory of the Faculty of Medicine, Syarif Hidayatullah State Islamic University Jakarta.
Engineered Stem Cell-Derived Exosomes for Precision Regenerative Medicine: Molecular Targeting, Cargo Optimization, and Therapeutic Applications Ghea Farmaning Thias Putri; Dwi Widyawati; Firda Asma'ul Husna; Rifdah Hanifah; Nabila Aulia Tsaqifah
International Journal of Cell and Biomedical Science Vol 5 No 13 (2026)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v5i13.85

Abstract

Regenerative medicine has increasingly transitioned from cell-based therapies to cell-free approaches due to the constraints of stem cell transplantation, such as limited engraftment efficiency, immunogenicity, tumorigenic potential, and difficulties in clinical standards. Among novel cell-free methodologies, stem cell-derived exosomes have garnered considerable interest as nanoscale extracellular vesicles that facilitate tissue repair via paracrine signaling. Recent advancements in molecular biology and bioengineering have facilitated the creation of modified exosomes, permitting precise alterations of surface molecules and bioactive cargo to improve therapeutic specificity and efficacy. This narrative review encapsulates current advancements in synthetic stem cell-derived exosomes for precision regenerative medicine, emphasizing molecular targeting techniques, therapeutic cargo optimization, and applicability across various disease types. Literature pertinent to the years 2020 to 2025 was sourced from PubMed, Scopus, and ScienceDirect and subjected to qualitative analysis. The results demonstrate that modified exosomes can efficiently regulate critical biological pathways associated with apoptosis, inflammation, angiogenesis, and tissue regeneration. Improved targeting specificity increases tissue accumulation and therapeutic efficacy, while tailored cargo allows for precise modulation of molecular signaling in damaged microenvironments. Despite encouraging preclinical results, challenges related to production standardization, cargo uniformity, dosage optimization, and long-term safety hinder clinical translation. However, ongoing advancements in bioengineering, nanotechnology, and regulatory structures position modified exosomes as strong contenders for the development of next-generation regenerative therapeutics. Engineered stem cell-derived exosomes are a versatile and unique platform with considerable promise to connect molecular mechanisms and clinical applications in precision regenerative medicine.
From Oxidative Stress to Fibrogenesis: A Comprehensive Review of a Composite Oxidative-Fibrotic Index in Hypoxia-Associated MAFLD Dwi Widyawati; Ghea Farmaning Thias Putri; Ayu Tiara Fitri; Rifdah Hanifah; Nabila Aulia Tsaqifah; Yani Dwi Lestari; Rossa Amelia
International Journal of Cell and Biomedical Science Vol 5 No 13 (2026)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v5i13.91

Abstract

Metabolically associated fatty liver disease (MAFLD) is a leading cause of chronic liver disease, with fibrosis representing the strongest predictor of adverse clinical outcomes. Emerging evidence suggests that intermittent hypoxia, commonly associated with obstructive sleep apnea, contributes to fibrosis progression through oxidative stress-mediated mechanisms. This review aims to synthesize current evidence on the role of intermittent hypoxia in driving oxidative stress and hepatic fibrogenesis in MAFLD, and to propose a Composite Oxidative-Fibrotic Index as an integrative biomarker framework. A narrative review was conducted using major biomedical databases to identify experimental and clinical studies evaluating hypoxia-induced oxidative stress, redox-sensitive signaling pathways, and fibrogenic responses in MAFLD. Intermittent hypoxia induces repetitive hypoxia-reoxygenation cycles that promote reactive oxygen species generation, impair antioxidant defenses, and activate redox-sensitive pathways, including HIF-1α, NF-κB, and Nrf2 dysregulation. These mechanisms contribute to hepatic stellate cell activation, extracellular matrix remodeling, and increased liver stiffness. Evidence indicates that individual oxidative and fibrogenic biomarkers are insufficient to capture the dynamic progression of fibrosis. The proposed Composite Oxidative-Fibrotic Index integrates oxidative stress markers, signaling mediators, fibrogenic indicators, and liver stiffness measurement into a unified framework. This approach may improve early detection, risk stratification, and monitoring of fibrosis progression in hypoxia-associated MAFLD, with potential implications for biomarker-guided clinical management and targeted therapeutic strategies.
Biomedical Profile of Hemoglobin Level, Nutritional Status, and Blood Type in Community-Based Health Screening at Pematang Kamasan Posyandu Firda Asma’ul Husna; Ghea Farmaning Thias Putri; Dwi Widyawati; Rifdah Hanifah
International Journal of Cell and Biomedical Science Vol 5 No 13 (2026)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v5i13.94

Abstract

Background: Community-based health screening is essential for the early detection of hematological abnormalities, nutritional disorders, and limited health awareness, particularly in rural populations with restricted access to routine medical services. Objective: This study aimed to describe hemoglobin levels, body mass index (BMI) status, blood type distribution, and community health knowledge among residents participating in Posyandu-based screening in Pematang, Kamasan Village. Methods: A descriptive observational study was conducted using secondary data from community health screening. Among 143 attendees, complete biomedical and knowledge assessment data were available for 45 participants. Variables included sex, hemoglobin level, BMI category, blood type, and awareness of personal blood type and hemoglobin status. Data were analyzed descriptively using frequency distribution, percentage, and mean ± standard deviation. Results: Female participants predominated in the screened population. Blood group O was the most common type, and obesity represented the dominant BMI category. Mean hemoglobin levels in both males and females were generally within normal physiological ranges. Despite measurable biomedical parameters, most participants were unaware of their personal blood type and hemoglobin status, indicating low community health literacy. Conclusion: This study demonstrates a coexistence of relatively normal hemoglobin status with high obesity prevalence and limited biomedical awareness in a rural community. Strengthening integrated community screening combined with targeted health education is necessary to improve preventive health behavior and reduce future cardiometabolic risk.
Co-Authors Ainina Al Shadrina Ainina Al Shadrina Al Shadrina, Ainina Ayu Tiara Fitri Devy Ariany Dwi Widyawati Dwi Widyawati Dwi Widyawati Dwi Widyawati Ekawati Rini Wulansari Firda Asma'ul Husna Firda Asma’ul Husna Galang Prahanarendra Hidayati, Mailani Dwi Husna, Firda Asma'ul Husna, Firda Asmaul Luluk Hermawati Nabila Aulia Tsaqifah Nabila Aulia Tsaqifah Nurfatihah Z, Zahara Nurlaely Mida Rachmawati Pratiwisitha, Maytia Rifdah Hanifah Rifdah Hanifah Rifdah Hanifah Rifdah Hanifah Rifdah Hanifah Rossa Amelia Widyawati, Dwi Yani Dwi Lestari