Article Per Year (5 Year)
p-Index From 2020 - 2025
0.562
P-Index
This Author published in this journals
All Journal Biofaal Journal International Journal of Cell and Biomedical Science Masyarakat Mandiri: Jurnal Pengabdian Dan Pembangunan Lokal
Ghea Farmaning Thias Putri
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Penguatan Perilaku Hidup Sehat dan Bermoral melalui Edukasi Anti-Narkoba, Anti-Bullying, dan Anti-Korupsi Ekawati Rini Wulansari; Luluk Hermawati; Ghea Farmaning Thias Putri; Rifdah Hanifah; Ainina Al Shadrina; Dwi Widyawati
Masyarakat Mandiri : Jurnal Pengabdian dan Pembangunan Lokal Vol. 2 No. 4 (2025): Oktober: Masyarakat Mandiri : Jurnal Pengabdian dan Pembangunan Lokal
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/masyarakatmandiri.v2i4.2032

Abstract

Early character education plays a fundamental role in shaping a generation that is not only intelligent but also physically healthy, emotionally balanced, and morally responsible. The cultivation of these values from an early age is crucial to equip children with the resilience needed to face various social challenges in the future. This community service activity was designed to increase awareness among elementary school students regarding three critical issues: the dangers of drug abuse, the practices of bullying, and the detrimental impact of corruption. The program was conducted at SDN 1 Citeluk with the participation of approximately 80 students from grades IV to VI. The educational materials were delivered through an interactive approach combining lectures, group discussions, role-playing, and quizzes. This approach was selected to ensure that the learning process was enjoyable, engaging, and easily understood by children at the elementary school level. During the sessions, students were introduced to the basic concepts of drugs, their harmful effects on health and life, and the importance of avoiding them. Additionally, the program emphasized identifying the various forms of bullying—whether physical, verbal, or social—and encouraged students to develop empathy and mutual respect. Another important aspect addressed was corruption, where students were guided to recognize the value of honesty and integrity through relatable examples in daily life. The results of the activity revealed that students were able to clearly understand the dangers of drugs, recognize the different forms of bullying, and provide examples of honest and moral behavior. This indicates that early character education delivered through interactive and participatory methods can effectively enhance children’s comprehension of healthy and moral values. It is expected that similar programs can be carried out sustainably in elementary school settings as part of continuous character-building efforts to support the development of a responsible and ethical young generation
Bax/Bcl-2 Ratio as the Golden Marker of Apoptosis: Molecular Mechanisms and Regulatory Pathways Putri, Ghea Farmaning Thias; Nurfatihah Z, Zahara
International Journal of Cell and Biomedical Science Vol 4 No 10 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i10.65

Abstract

Apoptosis is an essential biological mechanism responsible for maintaining tissue homeostasis by removing unnecessary or damaged cells. Among the key molecular regulators, the interplay between the pro-apoptotic protein Bax and the anti-apoptotic protein Bcl-2 determines cellular fate. The Bax/Bcl-2 ratio has been recognized as the “golden marker” of apoptosis, representing the fine equilibrium between survival and death signaling pathways within cells. This review aims to provide an updated overview of recent advances in understanding the molecular mechanisms and regulatory networks that control the Bax/Bcl-2 ratio and its significance as a diagnostic and therapeutic biomarker. Relevant studies were systematically identified from PubMed, Scopus, ScienceDirect, and Google Scholar, focusing on publications from 2020 to 2025. Current evidence suggests that the Bax/Bcl-2 ratio is influenced by transcriptional regulation involving p53, NF-κB, and Akt/PI3K pathways, as well as by post-translational modifications such as phosphorylation and ubiquitination that govern mitochondrial membrane permeabilization. Clinically, alterations in this ratio correlate with disease progression, therapeutic response, and prognosis in cancer, neurodegenerative, and renal disorders. Targeting this ratio through modulation of upstream regulators or BH3 mimetics offers promising therapeutic potential. In conclusion, a deeper understanding of the Bax/Bcl-2 ratio provides crucial perspectives for advancing diagnostic innovation and developing targeted therapies for apoptosis-related diseases.
Diagnostic and Prognostic Relevance of Circulating microRNAs across Multiple Cancer Types Putri, Ghea Farmaning Thias; Husna, Firda Asmaul; Widyawati, Dwi; Nurfatihah Z, Zahara
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp159-172

Abstract

Cancer represents a global health burden characterized by high morbidity and mortality,underscoring the urgent demand for reliable, non-invasive biomarkers to enhance early detection,prognostication, and therapeutic monitoring. Circulating microRNAs (c-miRNAs) are short non-coding RNAs present in body fluids that have attracted attention as potential biomarkers, because of their stability, ease of detection, and close relationship with tumor biology. This review evaluates the diagnostic and prognostic potential of c-miRNAs and their integration into precision oncology. A systematic search was performed across PubMed, Scopus, and ScienceDirect for publications from 2010 to 2025 that investigated c-miRNAs in human body fluids in relation to diagnosis, prognosis, or treatment response. Twelve studies met the eligibility criteria, encompassing breast, lung, colorectal, and gallbladder cancers. Frequently dysregulated c-miRNAs, particularly miR-21, miR-155, miR-210, and Let-7a, demonstrated consistent associations with tumor detection, patient survival, and disease progression. Analytical platforms ranged from quantitative RT-PCR to advanced biosensor-based technologies, enabling sensitive and rapid quantification. Collectively, the evidence highlights c-miRNAs as non-invasive biomarkers capable of complementing conventional clinical tools. Their clinical adoption could reduce reliance on invasive tissue biopsies, support earlier and more accurate diagnosis, assist in tailoring patient-specific treatment strategies, and promote the broader implementation of precision medicine in cancer care.
Co-Authors Ainina Al Shadrina Ekawati Rini Wulansari Husna, Firda Asmaul Luluk Hermawati Nurfatihah Z, Zahara Rifdah Hanifah Widyawati, Dwi