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All Journal Nusantara Medical Science Journal Biofaal Journal International Journal of Cell and Biomedical Science Jurnal Sains dan Kesehatan Masyarakat Mandiri: Jurnal Pengabdian Dan Pembangunan Lokal
Ghea Farmaning Thias Putri
Sultan Ageng Tirtayasa University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Penguatan Perilaku Hidup Sehat dan Bermoral melalui Edukasi Anti-Narkoba, Anti-Bullying, dan Anti-Korupsi Ekawati Rini Wulansari; Luluk Hermawati; Ghea Farmaning Thias Putri; Rifdah Hanifah; Ainina Al Shadrina; Dwi Widyawati
Masyarakat Mandiri : Jurnal Pengabdian dan Pembangunan Lokal Vol. 2 No. 4 (2025): Oktober: Masyarakat Mandiri : Jurnal Pengabdian dan Pembangunan Lokal
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/masyarakatmandiri.v2i4.2032

Abstract

Early character education plays a fundamental role in shaping a generation that is not only intelligent but also physically healthy, emotionally balanced, and morally responsible. The cultivation of these values from an early age is crucial to equip children with the resilience needed to face various social challenges in the future. This community service activity was designed to increase awareness among elementary school students regarding three critical issues: the dangers of drug abuse, the practices of bullying, and the detrimental impact of corruption. The program was conducted at SDN 1 Citeluk with the participation of approximately 80 students from grades IV to VI. The educational materials were delivered through an interactive approach combining lectures, group discussions, role-playing, and quizzes. This approach was selected to ensure that the learning process was enjoyable, engaging, and easily understood by children at the elementary school level. During the sessions, students were introduced to the basic concepts of drugs, their harmful effects on health and life, and the importance of avoiding them. Additionally, the program emphasized identifying the various forms of bullying—whether physical, verbal, or social—and encouraged students to develop empathy and mutual respect. Another important aspect addressed was corruption, where students were guided to recognize the value of honesty and integrity through relatable examples in daily life. The results of the activity revealed that students were able to clearly understand the dangers of drugs, recognize the different forms of bullying, and provide examples of honest and moral behavior. This indicates that early character education delivered through interactive and participatory methods can effectively enhance children’s comprehension of healthy and moral values. It is expected that similar programs can be carried out sustainably in elementary school settings as part of continuous character-building efforts to support the development of a responsible and ethical young generation
Bax/Bcl-2 Ratio as the Golden Marker of Apoptosis: Molecular Mechanisms and Regulatory Pathways Putri, Ghea Farmaning Thias; Nurfatihah Z, Zahara
International Journal of Cell and Biomedical Science Vol 4 No 10 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i10.65

Abstract

Apoptosis is an essential biological mechanism responsible for maintaining tissue homeostasis by removing unnecessary or damaged cells. Among the key molecular regulators, the interplay between the pro-apoptotic protein Bax and the anti-apoptotic protein Bcl-2 determines cellular fate. The Bax/Bcl-2 ratio has been recognized as the “golden marker” of apoptosis, representing the fine equilibrium between survival and death signaling pathways within cells. This review aims to provide an updated overview of recent advances in understanding the molecular mechanisms and regulatory networks that control the Bax/Bcl-2 ratio and its significance as a diagnostic and therapeutic biomarker. Relevant studies were systematically identified from PubMed, Scopus, ScienceDirect, and Google Scholar, focusing on publications from 2020 to 2025. Current evidence suggests that the Bax/Bcl-2 ratio is influenced by transcriptional regulation involving p53, NF-κB, and Akt/PI3K pathways, as well as by post-translational modifications such as phosphorylation and ubiquitination that govern mitochondrial membrane permeabilization. Clinically, alterations in this ratio correlate with disease progression, therapeutic response, and prognosis in cancer, neurodegenerative, and renal disorders. Targeting this ratio through modulation of upstream regulators or BH3 mimetics offers promising therapeutic potential. In conclusion, a deeper understanding of the Bax/Bcl-2 ratio provides crucial perspectives for advancing diagnostic innovation and developing targeted therapies for apoptosis-related diseases.
Diagnostic and Prognostic Relevance of Circulating microRNAs across Multiple Cancer Types Putri, Ghea Farmaning Thias; Husna, Firda Asmaul; Widyawati, Dwi; Nurfatihah Z, Zahara
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp159-172

Abstract

Cancer represents a global health burden characterized by high morbidity and mortality,underscoring the urgent demand for reliable, non-invasive biomarkers to enhance early detection,prognostication, and therapeutic monitoring. Circulating microRNAs (c-miRNAs) are short non-coding RNAs present in body fluids that have attracted attention as potential biomarkers, because of their stability, ease of detection, and close relationship with tumor biology. This review evaluates the diagnostic and prognostic potential of c-miRNAs and their integration into precision oncology. A systematic search was performed across PubMed, Scopus, and ScienceDirect for publications from 2010 to 2025 that investigated c-miRNAs in human body fluids in relation to diagnosis, prognosis, or treatment response. Twelve studies met the eligibility criteria, encompassing breast, lung, colorectal, and gallbladder cancers. Frequently dysregulated c-miRNAs, particularly miR-21, miR-155, miR-210, and Let-7a, demonstrated consistent associations with tumor detection, patient survival, and disease progression. Analytical platforms ranged from quantitative RT-PCR to advanced biosensor-based technologies, enabling sensitive and rapid quantification. Collectively, the evidence highlights c-miRNAs as non-invasive biomarkers capable of complementing conventional clinical tools. Their clinical adoption could reduce reliance on invasive tissue biopsies, support earlier and more accurate diagnosis, assist in tailoring patient-specific treatment strategies, and promote the broader implementation of precision medicine in cancer care.
Targeting Hypoxia-Induced Oxidative Stress via Natural Antioxidant Modulation: From Cellular Signaling to Therapeutic Perspectives Dwi Widyawati; Ghea Farmaning Thias Putri; Rifdah Hanifah; Firda Asmaul Husna; Nabila Aulia Tsaqifah; Ainina Al Shadrina
International Journal of Cell and Biomedical Science Vol 4 No 12 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i12.76

Abstract

Hypoxia is a fundamental physiological and pathological condition that disrupts cellular homeostasis through the excessive generation of reactive oxygen species (ROS), leading to oxidative stress, inflammation, and organ dysfunction. The imbalance between ROS production and antioxidant defense mechanisms is a key contributor to cell injury and disease progression. This review aims to elucidate the molecular interactions among major redox-sensitive signaling pathways hypoxia-inducible factor 1 (HIF-1), nuclear factor kappa B (NF-κB), and nuclear factor erythroid 2-related factor 2 (Nrf2) in hypoxia-induced oxidative stress, and to highlight the therapeutic potential of natural antioxidants in modulating these pathways. Relevant literature published over the past five years (2020-2025) was systematically reviewed using databases including PubMed, Scopus, and ScienceDirect. The selected studies focused on molecular redox signaling, hypoxia-induced oxidative mechanisms, and the modulatory roles of natural phytochemicals such as Ficus carica bioactive compounds. Recent findings reveal that natural antioxidants regulate redox signaling by activating Nrf2-dependent antioxidant responses, suppressing NF-κB driven inflammation, and stabilizing HIF-1α under hypoxic conditions. Phytochemicals, particularly flavonoids and polyphenols, exhibit strong potential to restore oxidative balance, protect cellular integrity, and reduce hypoxia-induced damage. Modulating hypoxia-induced oxidative stress through natural antioxidant pathways offers a promising therapeutic strategy. A deeper understanding of the molecular crosstalk between redox signaling and phytochemical activity may provide new insights for developing preventive and therapeutic interventions against hypoxia-related disorders.
Maternal Obesity, Metabolic Syndrome, and Long-Term Effects on Offspring: A Developmental Origins of Health and Disease (DOHaD) Perspective Tsaqifah, Nabila Aulia; Hanifah, Rifdah; Husna, Firda Asma'ul; Hidayati, Mailani Dwi; Widyawati , Dwi; Putri, Ghea Farmaning Thias; Al Shadrina, Ainina
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.47907

Abstract

Introduction: The global prevalence of obesity among women of reproductive age has increased markedly over the past two decades, reaching 24% in high-income and 16% in low- and middle-income countries. This trend contributes to adverse maternal and neonatal outcomes, including a 2–4-fold higher risk of gestational diabetes, a threefold increase in preeclampsia, and up to a 50% higher caesarean delivery rate. Maternal metabolic disorders also have long-term consequences for offspring metabolic and cardiovascular health. Objective: To synthesize current biological and epidemiological evidence linking maternal metabolic status to offspring health within the Developmental Origins of Health and Disease (DOHaD) framework. Methods: A comprehensive search was conducted in PubMed, Scopus, and Web of Science from January 2015 to September 2025 using keywords related to maternal obesity, metabolic syndrome, DOHaD, offspring health, and epigenetics. Included studies comprised human and animal research with follow-up beyond two years, while case reports, editorials, and studies without long-term outcomes were excluded. Findings: From 22 eligible studies, consistent evidence indicates that maternal obesity and metabolic syndrome affect offspring through placental dysfunction, systemic inflammation, and epigenetic reprogramming. Offspring of obese mothers show a 1.5–2.8-fold increased risk of obesity and insulin resistance during adolescence and adulthood. Epigenome-wide analyses reveal altered methylation of genes regulating lipid metabolism (LEP, IGF2) and inflammatory pathways, supporting the DOHaD hypothesis. Conclusion: Maternal metabolic health critically shapes offspring developmental and metabolic outcomes. Preconception and antenatal interventions targeting metabolic optimization provide key opportunities to prevent intergenerational transmission of metabolic risk and promote healthier future generations.
Preliminary Study on Long Fixation in Histological Preparations of Internal Organs of Sprague Dawley Rats Prahanarendra, Galang; Ariany, Devy; Rachmawati, Nurlaely Mida; Hermawati , Luluk; Putri, Ghea Farmaning Thias
International Journal of Cell and Biomedical Science Vol 4 No 12 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i12.77

Abstract

Histotechnology is a series of processes ranging from tissue handling to the preparation of slides that can be observed under a microscope. One crucial stage in this process is fixation, which serves to preserve the structure and morphology of the tissue as close as possible to its original physiological state. However, prolonged fixation duration may lead to tissue hardening, dissolution, and structural damage. This study aims to obtain supporting data for the development of a standard operating procedure (SOP) in histotechnology that can be applied in the animal house and histology laboratories of the Faculty of Medicine, Syarif Hidayatullah State Islamic University Jakarta. The results showed that fixation for three weeks caused morphological damage to the kidney, liver, and pancreas of Sprague Dawley rats. The findings included tissue perforation in all three organs, endothelial nuclear damage in the kidney, central vein wall damage in the liver, and cellular disintegration in the pancreatic islets of Langerhans. Based on these findings, it can be concluded that a fixation duration of three weeks does not produce optimal histological images and therefore cannot be used as a reference for establishing a standard histotechnology SOP in the laboratory of the Faculty of Medicine, Syarif Hidayatullah State Islamic University Jakarta.
Profil Pengetahuan Data Kesehatan Dasar: Studi Deskriptif Mengenai Golongan Darah dan Hemoglobin pada Kelompok Usia Dewasa Muda: Basic Health Data Knowledge: A Descriptive Study of Blood Groups and Hemoglobin in Young Adults Husna, Firda Asma'ul; Hermawati, Luluk; Putri, Ghea Farmaning Thias; Pratiwisitha, Maytia
Jurnal Sains dan Kesehatan Vol. 8 No. 2 (2026): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v8i2.2630

Abstract

Blood type and hemoglobin (Hb) levels constitute essential basic health data that play a critical role in health screening, emergency medical management, and individual readiness for blood donation. Among university students, the availability and understanding of these basic health data remain challenging due to suboptimal levels of knowledge and limited screening history. This study aimed to analyze students’ knowledge levels regarding blood type and hemoglobin levels as basic health data and to explore their implications for personal health awareness and potential participation as blood donors. This research employed a descriptive observational design with randome sampling involving 143 students. Data were collected using a questionnaire to assess students’ knowledge levels and screening history related to blood type and hemoglobin levels. The results showed that 28% of students were unaware of their blood type, while approximately 77% had never known their hemoglobin levels. These findings indicate limited knowledge and screening history of basic health data, rather than reflecting clinically low hemoglobin levels. Overall, approximately two-thirds of students were aware of their blood type. The low level of knowledge regarding blood type and particularly hemoglobin levels reflect insufficient health screening awareness among young adults. Inadequate monitoring of hemoglobin levels may result in undetected anemia, potentially affecting health status and academic performance. Furthermore, limited knowledge of these health parameters may reduce students’ readiness to serve as potential blood donors. The availability of students’ basic health data related to blood type and hemoglobin levels remains suboptimal, highlighting the need for continuous health education and routine health screening programs within the university setting. Keywords:          blood type; hemoglobin; knowledge; basic health data; university students   Golongan darah dan kadar hemoglobin (Hb) merupakan data kesehatan dasar yang berperan penting dalam skrining kesehatan, penanganan kegawatdaruratan medis, serta kesiapan individu sebagai pendonor darah. Pada kelompok mahasiswa, ketersediaan dan pemahaman terhadap data kesehatan dasar ini masih menjadi tantangan karena tingkat pengetahuan dan riwayat pemeriksaan yang belum optimal. Penelitian ini bertujuan untuk menganalisis tingkat pengetahuan mahasiswa mengenai golongan darah dan kadar hemoglobin sebagai data kesehatan dasar serta implikasinya terhadap kesadaran kesehatan pribadi dan potensi keterlibatan sebagai pendonor darah. Penelitian ini merupakan studi observasional deskriptif dengan random sampling yang melibatkan 143 mahasiswa Data dikumpulkan menggunakan kuesioner untuk menilai tingkat pengetahuan dan riwayat pemeriksaan golongan darah serta kadar hemoglobin. Sebanyak 28% mahasiswa belum mengetahui golongan darahnya, sementara sekitar 77% mahasiswa belum pernah mengetahui kadar hemoglobinnya. Temuan ini menunjukkan rendahnya pengetahuan dan riwayat pemeriksaan terhadap data kesehatan dasar, bukan mencerminkan kondisi klinis kadar hemoglobin yang rendah. Secara umum, sekitar dua pertiga mahasiswa telah mengetahui golongan darahnya. Rendahnya pengetahuan mahasiswa terhadap golongan darah dan terutama kadar hemoglobin mencerminkan rendahnya kesadaran skrining kesehatan pada kelompok usia dewasa muda. Kurangnya pemantauan kadar hemoglobin berpotensi menyebabkan kondisi anemia tidak terdeteksi serta berdampak pada kesehatan dan performa akademik. Selain itu, keterbatasan pengetahuan ini juga memengaruhi kesiapan mahasiswa sebagai calon pendonor darah. Ketersediaan data kesehatan dasar mahasiswa terkait golongan darah dan kadar hemoglobin masih belum optimal, sehingga diperlukan edukasi dan skrining kesehatan berkelanjutan di lingkungan perguruan tinggi. Kata Kunci:         golongan darah; hemoglobin; pengetahuan; data kesehatan dasar; mahasiswa  
Co-Authors Ainina Al Shadrina Ainina Al Shadrina Al Shadrina, Ainina Ariany, Devy Dwi Widyawati Ekawati Rini Wulansari Hidayati, Mailani Dwi Husna, Firda Asma'ul Husna, Firda Asmaul Luluk Hermawati Nurfatihah Z, Zahara Prahanarendra, Galang Pratiwisitha, Maytia Rachmawati, Nurlaely Mida Rifdah Hanifah Rifdah Hanifah Widyawati, Dwi