<![CDATA[Amlodipine is a widely prescribed antihypertensive drug, but its side effect, peripheral edema, can cause discomfort and reduce patient compliance. The high prevalence of hypertension, including in Indonesia, makes understanding the balance between effectiveness and side effects crucial for both healthcare professionals and patients. The purpose of this literature review is to analyze the relationship between Amlodipine use and the risk of peripheral edema, including its mechanisms, risk factors, and clinical implications in therapeutic practice. The method used is a literature review with the PRISMA approach through a search of articles in the PubMed, Semantic Scholar, and Google Scholar databases using related keywords. Inclusion criteria included Indonesian and English-language articles published between 2015 and 2025 that discussed peripheral edema caused by Amlodipine. Of the 241 articles identified, only 5 articles met the criteria for further analysis. The analysis results showed that the incidence of peripheral edema ranged from 10% to 46.5%, with high doses and advanced age being the main risk factors. The main mechanism of edema is an imbalance in arteriolar and venular vasodilation that increases capillary hydrostatic pressure. Effective management strategies include combination with an ACE inhibitor/ARB, dose reduction, or the use of (S)-amlodipine as an alternative. In conclusion, amlodipine remains effective as an antihypertensive therapy, but peripheral edema is a common side effect and can impair quality of life and patient compliance. Therefore, monitoring risk factors and implementing appropriate management strategies are essential to optimize therapy.]]>
