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All Journal E-Prodenta Journal of Dentistry Indonesian Health Journal
Fadhilah, Nadia
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Effectiveness Of Ciplukan Stem Water Extract (Physalis Minima L.) On Malondialdehyde Levels Of Mandibular Bones Of White Rats (Rattus Norvegicus) Wistar Strain Post Ovariectomy Fadhilah, Nadia; Permatasari, Nur; Widodorini, Trining
Indonesian Health Journal Vol. 4 No. 3 (2025): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v4i3.808

Abstract

Estrogen functions as an antioxidant that can suppress free radicals. Hypoestrogenic conditions will increase oxidative stress. Periodontitis is a disease related to oxidative stress. The occurrence of oxidative stress is characterized by increased levels of malondialdehyde (MDA). Malondialdehyde is commonly used to assess oxidative stress. Phytoestrogens are components of plants that have biological activity similar to estrogen. Ciplukan plants are suspected to be phytoestrogen compounds. Based on theoretical studies, it is suspected that the ciplukan stem contains physalin, which has a similar effect to the action of estrogen. The purpose of this study was to determine the effectiveness of ciplukan stem water extract on the level of malondialdehyde of the mandibular bone in white rats of the post-wistar strain ovariectomy. Twenty-four mice were randomly divided into 6 groups with 4 mice each, namely 3 control groups and 3 treatment groups of mice given an extract dose of 500 mg/kgBB, 1,500 mg/kgBB, and 2,500 mg/kgBB for 4 weeks. MDA levels were calculated by thiobarbituric acid (TBA) test and read with a spectrophotometer, kemudian made MDA work curve. The results showed that the increase in MDA levels could be inhibited by the administration of a dose of 500 mg/kg BB, while a dose of 1500 mg/kg BB 2500 mg/kg BB could improve MDA levels close to normal. There was a strong correlation with a negative direction between the dose of ciplukan stem water extract and the MDA level of the mandibular bone (r=--0.507). The conclusion of this study is that the administration of ciplukan stem water extract can reduce the MDA level of mandibular bone in white rats of wistar strain after oophorectomy.
EFEKTIVITAS EKSTRAK AIR BATANG CIPLUKAN (Physalis minima L.) TERHADAP KADAR MALONDIALDEHID TULANG MANDIBULA TIKUS PUTIH (Rattus norvegicus) Strain Wistar Pasca Ovariectomy Fadhilah, Nadia; Permatasari, Nur; Widodorini, Trining
E-Prodenta Journal of Dentistry Vol 9 No 2 (2025)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2025.009.02.2

Abstract

Estrogen has function as an antioxidant that can reduce free radicals. Hipoestrogen condition will increase oxidative stress in the body. Periodontitis is one of the diseases associated with oxidative stress. Oxidative stress, characterized by increased levels of malondialdehid (MDA). Malondialdehid is usually used to assess the oxidative stress. Phytoestrogens are plant components that have biological activity of estrogen. Ciplukan is a natural ingredient or plant suspected to be a phytoestrogen compound. The theoretical study results showed that ciplukan stem contained physalin, which have a similar effect to estrogen. The purpose of this study is to determine the effectiveness of ciplukan stem extract on malondialdehyde levels in the rat mandibular bone post ovariectomy. Twenty four rats were randomly divided into 6 groups with each 4 rats, that are 3 control groups and 3 groups treated rats that were given the ciplukan stem extract at the end of the first 5 weeks ovariectomy with three different doses: 500 mg/kg BW (K4), 1.500 mg/kg BW (K5), and 2.500 mg/kg BW (K6) for 4 weeks. MDA levels calculated by thiobarbituric acid (TBA) test and read by a spectrophotometer and MDA standard curve created. The results showed the incease of MDA levels can be inhibited at the dose of 500 mg / kg, while at the dose of 1500 mg/kg BW and 2500 mg/kg BW can restore MDA levels similar to normal. There is a strong correlation between the negative direction doses of ciplukan stem extract with MDA levels in mandibular bone (r = -0.507). The conclusion of this study is the ciplukan stem extract can reduce MDA levels in mandibular bone strain of wistar rats after ovariectomy.
Co-Authors Nur Permatasari Widodorini, Trining