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Satria, Raasikhah Aadilah
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Economics, Econometrics & Finance Education Environmental Science Law, Crime, Criminology & Criminal Justice Social Sciences

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Dose-dependent muscle relaxant activity of avocado leaf (Persea americana Mill.) extract: Central nervous system effects in mice and implications for phytopharmaceutical development Alsabianti, Nur Ahya; Nampe, Dian Febrianti Putri; Arianti, Ririn; Durratunnafisa, Ihda; Satria, Raasikhah Aadilah; Wahyuni, Resky; Azhara, Wa Ode Kezya; Nurjannah, Nurjannah; Jufri, Agniatul Azizah; Ningrum, Andi Utari Prasetya
Priviet Social Sciences Journal Vol. 5 No. 12 (2025): December 2025
Publisher : Privietlab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55942/pssj.v5i12.1310

Abstract

Avocado leaves (Persea americana Mill.) contain flavonoids, saponins, and phenols, which are thought to exert muscle-relaxing effects through central nervous system depressant mechanisms. This study investigated the muscle-relaxing effects of avocado leaf extract (Persea americana) in male mice. Nine male mice were divided into three groups and administered 1%, 2%, and 4% avocado leaf infusions orally. Motor activity and reflex responses were observed every 15 min until the 100th min to assess muscle relaxation effects. The results showed that the muscle-relaxation effect increased with increasing extract concentration, at 15.55%, 34.44%, and 42.22%, respectively. Flavonoids and saponins are thought to play a role in increasing GABA activity, which reduces muscle tone. Avocado leaf extract showed muscle relaxation effects that increased with dose and has the potential to be a natural muscle relaxant through GABA activation.
Co-Authors Alsabianti, Nur Ahya Azhara, Wa Ode Kezya Durratunnafisa, Ihda Jufri, Agniatul Azizah Nampe, Dian Febrianti Putri Ningrum, Andi Utari Prasetya Nurjannah Nurjannah Ririn Arianti, Ririn Wahyuni, Resky