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All Journal JURNAL FARMASIMED (JFM) Contagion: Scientific Periodical Journal of Public Health and Coastal Health Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Pharmaceutical and Clinical Research Journal of Functional Food and Nutraceutical Jurnal Penelitian Farmasi dan Herbal Journal of Pharmaceutical and Health Research Journal of Multidisciplinary Applied Natural Science Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal
Vera Estefania Kaban
Program Studi Farmasi, Sekolah Tinggi Ilmu Kesehatan (STIKes) Senior Medan
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Transportation Veterinary

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UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus niruri L.) Dan KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS JANTAN PUTIH Herviani Sari; Vera Estefania Kaban; Friska Raulina Situmorang; Firdaus Fahdi
Jurnal Penelitian Farmasi & Herbal Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i1.79

Abstract

Purpose: To determine the effect of decreasing blood glucose levels in white rats using a combination of meniran and rosella compared to glibenclamide. Method: This research was carried out experimentally. Simplicia of meniran leaves and rosella macerated using 80% ethanol. The research used 21 rats that were induced by alloxan and divided into 7 groups and all compared using glibenclamide.Group 1 (negative control) CMC Na 1%, group 2 (positive control) glibenclamide dose 0.45 mg/kgMB, group 3 single roselle extract dose 130 mg/kgMB, group 4 single meniran leaf extract dose 200 mg/kgMB, group 5 combination of meniran leaf extract dose of 100 mg/kgMB and rosella extract dose of 65 mg/kgMB, group 6 combination of meniran leaf extract dose of 200 mg/kgMB and rosella extract dose of 130 mg/kgMB, and group 7 meniran leaf extract combination dose 400 mg/kgMB and rosella extract dose 195 mg/kgMB. Result: The results showed that rats had hyperglycemia after being induced by alloxan.Data were analyzed using one way ANOVA method followed by LSD and tukeys' B post hoct test. Having a difference in the decrease in blood glucose levels between the positive control group and the five doses of meniran extract and rosella gave a significant effect compared to the negative control group did not have a significant effect in reducing blood glucose levels. Conclusion: Single meniran extract and high-dose combination extract are more effective than glibenclamide.
EFEKTIVITAS PENYEMBUHAN LUKA SAYAT MENGGUNAKAN SALEP EKSTRAK ETANOL DAUN SENGGANI (Melastoma malabathricum L.) PADA KELINCI Vera Estefania Kaban; Jessi Octavia Aritonang; Yulia Citra Hasibuan; Dian Ika Perbina Meliala
Jurnal Penelitian Farmasi & Herbal Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i2.207

Abstract

Senggani plants also have a reddish purple flower, ripe fruit will break the color purple and reddish brown beans. However, the utilization of senggani leaves is still not getting attention, therefore, to increase the economic value and utilization of this plant, senggani leaf can be formulated in the extract ointment of senggani leaf ethanol to healing the cut on the rabbit so it is expected to give healing effect on the rabbit wound.The purpose of this research is to know the concentration of ethanol extract of senggani leaf in the formulation of the ointment which is most effective in healing the rabbit wound in rabbit and to know the ointment ratio of ethanol extract of senggani leaves with betadine ointment .The samples in this study were extract from senggani leaf extracted by maceration using 80% ethanol solvent and formulated in ointment preparation using ingredients of adeps lanae and vaseline album. All data were tested statistically using ANOVA ONE WAY.Preparation of ointment extract of ethanol senggani leaf can accelerate the healing process of the wound and the most effective is the syrup leaf extract of 50% with an average healing for 11 days while betadine ointment does not experience healing until day 14.Indicating differences between treatment groups were more effective in healing of cuts on rabbits and 50% extracts of ethanol extracts of senggani leaf were more effective than with betadine ointment.
Aktivitas Antibakteri Ekstrak Etanol Daun Pepaya (Carica papaya Linn.) Terhadap Bakteri Pseudomonas aeruginosa Nasri Nasri; Vera Estefania Kaban; Kasta Gurning; Hariyadi Dharmawan Syahputra; Denny Satria
INSOLOGI: Jurnal Sains dan Teknologi Vol. 1 No. 3 (2022): Juni 2022
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (376.277 KB) | DOI: 10.55123/insologi.v1i3.438

Abstract

Pseudomonas aeruginosa is a Gram-negative bacterium that can cause nosocomial infections. The use of antibiotics in the treatment of non-adherent P. aeruginosa infections increases the risk of antibiotic resistance. Efforts to find new antibiotic compounds from plants continue to be carried out. Papaya leaves are widely spread among the public, which are often used as ingredients for vegetables and have antibacterial potential because they contain papain enzymes and a class of flavonoid compounds. The purpose of this study was to analyze the antibacterial activity of the ethanol extract of papaya leaves (Carica papaya Linn.) against P. aeruginosa by finding the value of the Minimum Inhibitory Concentration (MIC) and calculating the index activity value against the positive control. The method used in this research is Kirby-Bauer (disc diffusion method) with several variations of the test concentration. The results showed that the diameter of the inhibition zone at a concentration of 500 mg/mL was in the strong category with an inhibition zone diameter of 10.87 ± 0.06 mm. MIC at a concentration of 3.125 mg/mL. The index activity value was greatest at a concentration of 500 mg/mL with a value of 0.668. So it can be concluded that the ethanol extract of papaya leaves (Carica papaya Linn.) has inhibitory activity against Pseudomonas aeruginosa.
Antibacterial Potential Ethanol Extract of Papaya Leaves (Carica papaya Linn.) Towards Salmonella typhi Mahatir Muhammad; Nasri Nasri; Vera Estefania Kaban; Denny Satria; Henni Cintya
BEST Journal (Biology Education, Sains and Technology) Vol 5, No 2 (2022): September 2022
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v5i2.5717

Abstract

Infectious diseases are a problem of great concern throughout the world. Bacterial infections such as Salmonella typhi often attack children and cause diarrhea and typhoid fever. Salmonella typhi is a beflagellated Gram negative bacteria that can be transmitted through contaminated food, drink, or water. Treatment of infections using antibiotics, where often the use of antibiotics is not achieved on the therapeutic target due to lack of patient compliance in taking antibiotics, will cause new problems, namely problems related to antibiotic resistance. Papaya leaf is a plant originating from the Caricaceae family which, based on studies, has been reported to have antimicrobial, antidiabetic, and immunomodulatory effects. The purpose of this study was to examine the antibacterial potential of ethanol extract of papaya leaves (Carica papaya Linn.) against Salmonella typhi bacteria. This research method uses the agar diffusion method (Kirby-Bauer) with various concentrations to determine the minimum inhibitory concentration (MIC) and the streaking method to determine the minimum killing concentration (MBC). The minimum inhibitory concentration was obtained at a concentration of 3.125 mg/mL with an inhibitory zone diameter of 6.70 ± 0.20 mm and a minimum killing concentration of 50 mg/mL. The index activity value at a concentration of 300 mg/mL was 0.688 ± 0.05. So it can be concluded that the ethanol extract of papaya leaves has potential antibacterial activity against Salmonella typhi bacteria.
Pemeriksaan dan Pemberian Obat Anemia Kepada Ibu Hamil di Desa Kota Pari Pantai Cermin Nasri Nasri; Vera Estefania Kaban; Kasta Gurning; Chyntia Glori Tania
ABDIKAN: Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Vol. 1 No. 3 (2022): Agustus 2022
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/abdikan.v1i3.787

Abstract

The incidence of anemia in pregnant women carries a great risk because the fetus's need for iron and oxygen supply during development requires iron. This community service activity aims to examine and administer anemia drugs or blood boosters to pregnant women and provide education related to anemia and important nutritional intake for pregnant women to prevent risk factors for anemia. A total of 36 pregnant women patients checked themselves, with 12 in the first trimester, 15 in the second trimester, and 9 in the third trimester. A total of 7 people in the first trimester experienced anemia (19.44%), 10 people in the second trimester (27.77%), and 5 people in the third trimester (13.88%). The rest do not have anemia. This can be due to the fact that the intake of balanced nutrition and foods rich in iron is sufficient during pregnancy. Iron intake during pregnancy in the first trimester is recommended at as much as 0.8 mg/day, while in the second and third trimesters, as much as 6.3 mg/day. Thus, it is hoped that the imparted knowledge and information will be adhered to in order to limit the risk of anemia in pregnant women so that the process of pregnancy until birth will proceed without incident.  
Formulasi Sediaan Lip Cream Ekstrak Daun Miana (Coleus scuatellariodes [L] Benth.) sebagai Pewarna Alami Vera Estefania Kaban; Nasri Nasri; Kasta Gurning; Hariyadi Dharmawan Syahputra; Zulmai Rani
INSOLOGI: Jurnal Sains dan Teknologi Vol. 1 No. 4 (2022): Agustus 2022
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v1i4.719

Abstract

Miana leaf (Coleus scutellarioides L.) is a plant that contains anthocyanins that can provide certain dyes. The purpose of this study was to formulate miana leaf extract in lip cream preparations as a natural dye. The research method includes the manufacture of ethanol extract of miana leaves (Coleus scutellarioides L.) by maceration method. The extract formulas used were 25%, 50%, and 75%. The tests carried out included organoleptic tests, homogeneity tests, physical tests, pH tests, irritation tests and color preference tests. The results of the lip cream preparation, the results of the organoleptic examination were declared to have a semi-solid dosage form, distinctive odor and varied colors F1 pink F2 purplish red, F3 blackish red, homogeneity test results were declared homogeneous, stability test results showed that the preparation did not change shape, color and the odor of the preparation for 14 days of storage, the results of the pH test showed that the preparation was still within the permissible pH range on the use of the skin, the test results were declared non-irritating. Miana leaf ethanol extract can be made as a colorant in lip cream preparations.
Mekanisme Antibakteri Ekstrak Etanol Daun Kemangi (Ocimum basilicum L.) terhadap Salmonella typhi Nasri Nasri; Vera Estefania Kaban; Denny Satria; Hariyadi Dharmawan Syahputra; Zulmai Rani
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3176

Abstract

Infectious diseases are conditions that can be brought on by a variety of different organisms, including bacteria, viruses, fungi, and parasites. Typhoid fever is an example of an infectious disease that frequently causes the body's defenses to come under attack. The fever associated with typhoid is a leading cause of death around the world. Infection with the bacterium Salmonella typhi is considered to be one of the potential causes of typhoid fever. When antibiotics are used to treat bacterial infections, there is a risk that the bacteria will become resistant to the medication. In day-to-day life, basil leaves are utilized both as a cooked vegetable and as a fresh vegetable. The antibacterial properties of kemangi leaves have yet to be fully uncovered. The purpose of this study was to investigate the various mechanisms that are involved in antibacterial activity. These mechanisms include cell leakage, minimum inhibitory concentration, minimum killing concentration, and antibiofilm activity. The minimum inhibitory concentration (MIC) was determined with the agar diffusion method, the minimum biofilm forming concentration (MBC) was determined with the staining method, and cell leakage was determined with UV-VIS spectrophotometry at wavelengths of 260 nm (DNA) and 280 nm (protein). Additionally, the formation of anti-biofilms was determined with microtiter plates and gentian violet staining. In the moderate category, the MIC value tests showed a concentration of 0.3125% with an inhibition zone value of 6.80 0.05 mm. These results were obtained from the MIC value. Because there was no detectable bacterial growth on the streaked medium, KBM was obtained at a concentration of 10%. At wavelengths of 260 and 280 nanometers, leakage cells show absorbance absorption. The percentage of biofilm activity that is measured when the concentration is increased to 25% is 44.82%. In conclusion, the ethanol extract of basil leaves possesses a possible antibacterial mechanism against Salmonella typhi. This was discovered through testing.
Uji Aktivitas Antibakteri Ekstrak Daun Karenda (Carissa carandas Linn.) Terhadap Bakteri Propionibacterium acne dan Staphylococcus epidermidis Vera Estefania Kaban; Nasri Nasri; Hariyadi Dharmawan Syahputra; Muhammad Fauzan Lubis; Denny Satria
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3181

Abstract

Karenda leaves contain flavonoids, steroids or triterpenoids, saponins, and tannins that act as antimicrobial compounds. The aim of the study was to determine the antibacterial activity of the ethanol extract of Karenda leaves against several acne-causing bacteria. The research method involved characterizing the simplicia of karenda leaves and extract preparation by maceration using 96% ethanol as a solvent. and test the antibacterial activity of the ethanol extract of Karenda leaves using the agar diffusion method. The bacteria used were Propionibacterium acnes and Staphylococcus epidermis. The extract concentrations used were 300, 150, 125, 100, 75, 50, 25, and 5 mg/mL. Based on tests carried out by the ethanol extract of karenda leaves, the diameters of the inhibition zones were 7.2 ± 0.12 respectively; 7.8±0.10; 9.7±0.15; 11.23±0.25; 12.43±0.06; 13.57±0.06; 14.20±0.10; 16.47 ± 0.21 for Propionibacterium acne and 8.17 ± 0.06; 9.37 ± 0.15; 9.80 ± 0.10; 10.73 ± 0.15; 11.27±0.12; 12.43±0.06; 13.77±0.06; 15.47 ± 0.12 for Staphylococcus epidermis. he test results proved that 300 mg/mL was the best concentration for inhibiting the growth of Propionibacterium acnes and Staphylococcus epidermis bacteria.
Peningkatan Pengetahuan Pola Hidup Bersih dan Sehat serta Penggunaan Vitamin pada Anak di Panti Asuhan Claresta Nasri Nasri; Vera Estefania Kaban; Hariyadi Dharmawan Syahputra; Junius Gian Ginting; Chyntia Glori Tania
ABDIKAN: Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Vol. 2 No. 1 (2023): Februari 2023
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/abdikan.v2i1.1712

Abstract

Achieving a healthy lifestyle requires a series of consistent steps, such as regular exercise, eating healthy and nutritious foods, getting enough rest, implementing a clean and healthy lifestyle, and consuming vitamins to boost external immunity. There is also concern about improving the health of children and adolescents, especially children who may have a minimal immune system that needs to be strengthened. The purpose of this activity is to provide education and counseling on how to live a clean and healthy lifestyle and to provide knowledge to children about the use of vitamins. The method of this activity is that children are first given questions for a pre-test about a clean and healthy lifestyle and vitamins, then present the material and close it with a post-test. As a result, only 8,57% of the students knew what a healthy lifestyle and vitamins were at the time of the pre-test. After the presentation of the material, the increase in children's knowledge increased by an average of 86,1%. The activity's conclusion is that it can teach children about living a healthy lifestyle and consuming vitamins. .  
A Simple Comparative Analysis on Self-Medication Knowledge and Effort of Health and Non-Health Students in Universitas Islam Negeri Sumatera Utara Wahyudi Wahyudi; Vera Estefania Kaban
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 5, No 1 (2023): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v5i1.14862

Abstract

Self medication  has advantages such as increases access to medication and also can  contribute to reducing prescribed drug costs. This study aims to describe the comparison of knowledge and efforts of self-medication health students (Faculty of Public Health/FPH) and non-health students (Faculty of Science and Technology/FST) in State Islamic University Of North Sumatera.  This research is a quantitative descriptive study using survey methods. Data collection was carried out using a questionnaire through the Google form which was then analyzed to be able to describe the results of the research. The research was conducted on 100 students (FPH n=50 and FST n=50) were students in semesters 1-6.  Self-medication knowledge on very good category are 80% for FPH and 16% for FST. The good category is 12% for FPH and 24%, the moderate category is for 4% FPH and 44% FST, the bad category is for 4% FPH and 12% FST, and the very bad category for FPH is absent and 4% for FST. Self-medication knowledge on very good category are 72% for FPH and 28% for FST. The good category is 18% for FPH and 26%, the moderate category is for 8% FPH and 36% FST, the bad category is for 2% FPH and 4% FST, and the very bad category for FPH is absent and 6% for FST. Health and non-health students both like the tablet drug form with a percentage of 56% and 64% respectively.  Conclusion- The conclusion of this study is that FPH students have a much better level of knowledge and self-medication efforts than FST. This could be because FPH students have a background in health education.  Keywords:   Knowledge, Medicine,  Self-Medication, Student.
Co-Authors Bangar, Roy Indrianto Barus, Bunga Rimta Br Sembiring, Novitaria Chiuman, Linda Chyntia Glori Tania Chyntia Glori Tania Denny Satria Dian Ika Perbina Meliala Firdaus Fahdi Friska Raulina Situmorang Ginting, Chrismis Novalinda Ginting, Junius Gian Harahap, Daimah Wirdatus Sanaun Hariyadi Dharmawan Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Henni Cintya Herviani Sari Iksen, Iksen Jansen Silalahi Jessi Octavia Aritonang Kasta Gurning Lumban Gaol, Irma Yohana Mahatir Muhammad Muhammad Fauzan Lubis Muhammad Fauzan Lubis Nasri N Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri Nasri, Nasri Ningsih, Wulan Seppia Raissa Fitri Razoki, Razoki Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Nurhakiki Sumaiyah Sumaiyah Syahputra, Hariyadi Dharmawan Wahyudi Wahyudi Waruwu, Loice Desy Krisna Yanti Wijaya, Johanna Fransiska Yulia Citra Hasibuan Yusmarlisa, Siti Zulmai Rani