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All Journal Jurnal Wawasan Pendidikan Indonesian Biodiversity Journal Indonesian Biodiversity Journal
Repi, Rudi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Veterinary Other

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THE EFFECT OF COMBINATION OF TURMERIC EXTRACT (Curcuma domestica Val.) AND HONEY ON GASTRIC ULCERS IN MICE (Mus musculus) DUE TO KETOPROFEN ADMINISTRATION MICROSCOPICALLY Sianturi, Novita Angraini; Repi, Rudi; Tengker, Anita C. C.
Indonesian Biodiversity Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/v1x5de96

Abstract

Gastric ulcers are one of the common side effects that occur as a result of using non-steroidal anti-inflammatory drugs (NSAIDS) such as ketoprofen. The combination of turmeric extract (Curcuma domestica Val) and honey has the potential as an alternative therapy due to its antioxidant, anti-inflammatory, and cytoprotective properties. This research aims to evaluate the effects of the combination of these two substances on gastric ulcers in mice induced by ketoprofen microscopically. To determine the effect of a combination of turmeric extract and honey on the histopathological profile of stomach ulcers in mice (Mus musculus) induced by ketoprofen. This study used an experimental method with a completely randomized design. Mice were divided into several groups, namely the negative control group (without treatment), positive control (ketoprofen without therapy), and the treatment group that was given a combination of turmeric extract and honey with varying doses. Gastric ulcers are induced by administration of ketoprofen, followed by microscopic observation of gastric mucosal damage. The data was analyzed statistically to see significant differences between groups. Histopathological observations show that the group given a combination of turmeric extract and honey experienced a significant reduction in the level of gastric mucosal damage compared to the positive control group. The combination is capable of reducing inflammation, necrosis, and accelerating tissue regeneration. The combination of turmeric extract and honey is effective in reducing gastric ulcers in mice induced by ketoprofen microscopically. This research supports the potential use of both natural substances as adjuvant therapy to prevent or address gastric damage caused by NSAIDS.
THE EFFECT OF COMBINATION OF TURMERIC EXTRACT (Curcuma domestica Val.) AND HONEY ON GASTRIC ULCERS IN MICE (Mus musculus) DUE TO KETOPROFEN ADMINISTRATION MICROSCOPICALLY Sianturi, Novita Angraini; Repi, Rudi; Tengker, Anita C. C.
Indonesian Biodiversity Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/v1x5de96

Abstract

Gastric ulcers are one of the common side effects that occur as a result of using non-steroidal anti-inflammatory drugs (NSAIDS) such as ketoprofen. The combination of turmeric extract (Curcuma domestica Val) and honey has the potential as an alternative therapy due to its antioxidant, anti-inflammatory, and cytoprotective properties. This research aims to evaluate the effects of the combination of these two substances on gastric ulcers in mice induced by ketoprofen microscopically. To determine the effect of a combination of turmeric extract and honey on the histopathological profile of stomach ulcers in mice (Mus musculus) induced by ketoprofen. This study used an experimental method with a completely randomized design. Mice were divided into several groups, namely the negative control group (without treatment), positive control (ketoprofen without therapy), and the treatment group that was given a combination of turmeric extract and honey with varying doses. Gastric ulcers are induced by administration of ketoprofen, followed by microscopic observation of gastric mucosal damage. The data was analyzed statistically to see significant differences between groups. Histopathological observations show that the group given a combination of turmeric extract and honey experienced a significant reduction in the level of gastric mucosal damage compared to the positive control group. The combination is capable of reducing inflammation, necrosis, and accelerating tissue regeneration. The combination of turmeric extract and honey is effective in reducing gastric ulcers in mice induced by ketoprofen microscopically. This research supports the potential use of both natural substances as adjuvant therapy to prevent or address gastric damage caused by NSAIDS.
PENGARUH MODEL PROBLEM BASED LEARNING DALAM MENINGKATKAN HASIL BELAJAR SISWA PADA MATERI SISTEM EKSKRESI KELAS XI MIPA DI SMA NEGERI 1 MOTOLING TIMUR Kaligis, Brigita Jenifer; Repi, Rudi; Tumbel, Ferny Margo
Jurnal Wawasan Pendidikan Vol 6, No 2 (2026): AGUSTUS 2026
Publisher : Fakultas Ilmu Pendidikan, Universitas Persatuan Guru Republik Indonesia Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/jwp.v6i2.25805

Abstract

This study investigated the extent to which the Problem-Based Learning (PBL) model enhances students’ academic performance on the Excretory System topic among 11th-grade learners at SMA Negeri 1 Motoling Timur. A quasi-experimental approach employing a Non-Equivalent Control Group design was utilized, involving two intact classes designated as the experimental and control groups. All 32 students from the 11th-grade science class were included as participants using a total sampling technique. Quantitative analysis revealed that the implementation of the PBL model significantly improved student learning outcomes. The superiority of the experimental group’s scores over those of the control group demonstrates that PBL is more effective than traditional instructional methods.
Co-Authors Kaligis, Brigita Jenifer Sianturi, Novita Angraini Tengker, Anita C. C.