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All Journal Indonesian Biodiversity Journal Indonesian Biodiversity Journal JIKMA
Tengker, Anita C. C.
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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THE EFFECT OF COMBINATION OF TURMERIC EXTRACT (Curcuma domestica Val.) AND HONEY ON GASTRIC ULCERS IN MICE (Mus musculus) DUE TO KETOPROFEN ADMINISTRATION MICROSCOPICALLY Sianturi, Novita Angraini; Repi, Rudi; Tengker, Anita C. C.
Indonesian Biodiversity Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/v1x5de96

Abstract

Gastric ulcers are one of the common side effects that occur as a result of using non-steroidal anti-inflammatory drugs (NSAIDS) such as ketoprofen. The combination of turmeric extract (Curcuma domestica Val) and honey has the potential as an alternative therapy due to its antioxidant, anti-inflammatory, and cytoprotective properties. This research aims to evaluate the effects of the combination of these two substances on gastric ulcers in mice induced by ketoprofen microscopically. To determine the effect of a combination of turmeric extract and honey on the histopathological profile of stomach ulcers in mice (Mus musculus) induced by ketoprofen. This study used an experimental method with a completely randomized design. Mice were divided into several groups, namely the negative control group (without treatment), positive control (ketoprofen without therapy), and the treatment group that was given a combination of turmeric extract and honey with varying doses. Gastric ulcers are induced by administration of ketoprofen, followed by microscopic observation of gastric mucosal damage. The data was analyzed statistically to see significant differences between groups. Histopathological observations show that the group given a combination of turmeric extract and honey experienced a significant reduction in the level of gastric mucosal damage compared to the positive control group. The combination is capable of reducing inflammation, necrosis, and accelerating tissue regeneration. The combination of turmeric extract and honey is effective in reducing gastric ulcers in mice induced by ketoprofen microscopically. This research supports the potential use of both natural substances as adjuvant therapy to prevent or address gastric damage caused by NSAIDS.
THE EFFECT OF COMBINATION OF TURMERIC EXTRACT (Curcuma domestica Val.) AND HONEY ON GASTRIC ULCERS IN MICE (Mus musculus) DUE TO KETOPROFEN ADMINISTRATION MICROSCOPICALLY Sianturi, Novita Angraini; Repi, Rudi; Tengker, Anita C. C.
Indonesian Biodiversity Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/v1x5de96

Abstract

Gastric ulcers are one of the common side effects that occur as a result of using non-steroidal anti-inflammatory drugs (NSAIDS) such as ketoprofen. The combination of turmeric extract (Curcuma domestica Val) and honey has the potential as an alternative therapy due to its antioxidant, anti-inflammatory, and cytoprotective properties. This research aims to evaluate the effects of the combination of these two substances on gastric ulcers in mice induced by ketoprofen microscopically. To determine the effect of a combination of turmeric extract and honey on the histopathological profile of stomach ulcers in mice (Mus musculus) induced by ketoprofen. This study used an experimental method with a completely randomized design. Mice were divided into several groups, namely the negative control group (without treatment), positive control (ketoprofen without therapy), and the treatment group that was given a combination of turmeric extract and honey with varying doses. Gastric ulcers are induced by administration of ketoprofen, followed by microscopic observation of gastric mucosal damage. The data was analyzed statistically to see significant differences between groups. Histopathological observations show that the group given a combination of turmeric extract and honey experienced a significant reduction in the level of gastric mucosal damage compared to the positive control group. The combination is capable of reducing inflammation, necrosis, and accelerating tissue regeneration. The combination of turmeric extract and honey is effective in reducing gastric ulcers in mice induced by ketoprofen microscopically. This research supports the potential use of both natural substances as adjuvant therapy to prevent or address gastric damage caused by NSAIDS.
Gambaran Kualitas Hidup Penderita Diabetes Melitus di Desa Adow Kabupaten Bolaang Mongondow Selatan Kolintama, Tahsya V. S.; Pongoh, Lucyana L.; Tengker, Anita C. C.; Sudirham, Sudirham; Manoppo, Jonesius E.; Makadada, Fredrik A.
JURNAL ILMIAH KESEHATAN MANADO Vol. 4 No. 3 (2025): JURNAL ILMIAH KESEHATAN MANADO (JIKMA)
Publisher : Yayasan Syalom Cipta Sumikolah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes Mellitus is a chronic disease that affects various aspects of patients' lives, including physical, psychological, social, and environmental aspects. Health center data show an increase in Diabetes Mellitus cases from 21 patients in 2023 to 60 patients in 2024. This increase indicates the importance of understanding the quality of life of patients in order to support prevention and disease management efforts.This study aimed to describe the quality of life of patients with Diabetes Mellitus based on physical, psychological, social relationship, and environmental aspects, as well as satisfaction and concerns related to the disease. This study used a quantitative descriptive method with a total sampling technique involving 60 patients with Diabetes Mellitus. Data were collected using the WHOQOL-BREF questionnaire and the Diabetes Quality of Life (DQOL) questionnaire. Data analysis was carried out using univariate analysis in the form of frequency distribution and percentages. The results showed that the quality of life of patients with Diabetes Mellitus in various aspects was mostly in the poor category. In the physical health aspect, the majority of respondents were in the poor category with 43 people (71.7%). In the psychological aspect, most respondents were in the moderate category with 41 people (68.3%). In the social relationship aspect, the majority of respondents were in the poor category with 37 people (61.7%), while in the environmental aspect most respondents were in the moderate category with 36 people (60%). However, based on the DQOL questionnaire, the diabetes-specific quality of life was in the high category (100%), indicating that respondents had good self-efficacy and high satisfaction in managing their disease.
Co-Authors . Fredrik Alfrets Makadada Jonesius Eden Manopo Kolintama, Tahsya V. S. Lucyana Leonita Pongoh Repi, Rudi Sianturi, Novita Angraini Sudirham, Sudirham