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All Journal Smart Medical Journal Journal of Midwifery
Ariesto, Mohammad Rizky
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health Social Sciences

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Evaluating Drug Safety in Pregnancy: A Hospital-Based Study on TGA Classification and Prescription Practices in Indonesia Sastranegara, Hawariyyun; Sutrisna, Eman; Nafisah, Nafisah; Priyanto , Edy; Purnawan, Iwan; Ariesto, Mohammad Rizky; Sulistyo, Hidayat
Journal of Midwifery Vol. 10 No. 2 (2025): Published on Desember 2025
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.10.2.48-56.2025

Abstract

Pregnant women are frequently prescribed medications, yet limited data exist on the safety profiles of these drugs in low-resource settings. The Therapeutic Goods Administration (TGA) classification system is a critical tool to evaluate fetal risks, but its application in Indonesian clinical practice remains understudied. This study aimed to analyze prescription patterns and TGA safety categories of drugs prescribed to pregnant women at a tertiary hospital in Indonesia. A cross-sectional study was conducted using medical records of 374 pregnant women at Bunda Arif Hospital (2021-2022). Drugs were classified according to TGA categories (A, B1, B2, B3, C, D, X). Data were analyzed descriptively (frequencies, percentages) and compared across trimesters. Most patients (63%) received one drug, primarily electrolytes/minerals/vitamins (67%). Based on TGA classification, 33% of drugs were Category A (safe), while 27% were Category D (e.g., high-dose Vitamin A). Notably, Category D drugs were increasingly prescribed across trimesters (12% in 1st trimester to 46% in 3rd trimester). No Category X drugs were identified. Conclusion: Despite overall adherence to safe prescribing (Category A), the high prevalence of Category D drugs, particularly Vitamin A, highlights a critical gap in perinatal pharmacovigilance. Clinicians should prioritize evidence-based guidelines to mitigate potential teratogenic risks in pregnancy.
Does Location Matter? Impact of Tumor Location (Peripheral vs Central) on Surgical Outcomes of Segmentectomy in Early Stage NSCLC: A Meta-Analysis Bawono, Mada Ilham; Ariesto, Mohammad Rizky; Mufidah, Belinda; Hari, Mada Dwi
Smart Medical Journal Vol 9, No 1 (2026): April
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v9i1.115488

Abstract

Introduction: Recent studies recommend segmentectomy for early-stage peripheral NSCLC due to better lung parenchyma preservation; however, its role in early-stage central NSCLC remains debated. This study aims to analyze the impact of tumor location (peripheral vs central) on segmentectomy outcomes in early-stage NSCLC.Methods: Only studies comparing segmentectomy outcomes by tumor location (peripheral vs central) in early-stage (T1a–cN0M0) NSCLC will be included. Studies involving lobectomy, wedge resection, or more advanced stages will be excluded. We registered the study protocol on PROSPERO (CRD420251127645). Article searches will be conducted in PubMed, Scopus, and Web of Science. All databases were last searched on 16 August 2025. Risk of bias will be assessed using the Newcastle–Ottawa Scale. Data will be analyzed with RevMan 5.4 and presented as forest plots.Result: Five cohort studies were included, comprising a total 2,134 participants (1,499 peripheral and 635 central tumours) were included. The meta-analysis findings indicated that there were no significant differences between peripheral and central tumor locations regarding 5-year overall survival, recurrence-free survival, recurrence patterns, or intraoperative blood loss. However, segmentectomy performed for peripheral tumors resulted in a significantly shorter operative duration compared with procedures for central tumors (SMD −0.20; 95% CI −0.30 to −0.10; p < 0.0001).Conclusion: This study has limitations due to the small sample size and study design, which affect its generalizability. Nevertheless, the analysis results indicate that segmentectomy is also a choice of treatment for early-stage central NSCLC.
Co-Authors Bawono, Mada Ilham Eman Sutrisna Hari, Mada Dwi Hidayat Sulistyo Iwan Purnawan Mufidah, Belinda Nafisah Nafisah Priyanto , Edy Sastranegara, Hawariyyun