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All Journal Journal of Innovation Research and Knowledge International Journal of Health, Engineering and Technology
Danny Ernest Jonas Luhulima
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Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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LABORATORY EXAMINATION OF HEMOLYTIC DISEASE IN NEONATES DUE TO RHESUS INCOMPATIBILITY Danny Ernest Jonas Luhulima; Christian Ronald Tanggo; Ria Amelia
Journal of Innovation Research and Knowledge Vol. 5 No. 8 (2026): Januari 2026
Publisher : Bajang Institute

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Abstract

Hemolytic disease of the newborn (HDN) occurs when fetal red blood cells (RBCs), which possess an antigen that the mother lacks, cross the placenta into the maternal circulation, where they stimulate antibody production. The antibodies return to the fetal circulation and result in RBC destruction. Three classifications of HDN are: ABO, other causes like unexpected immune antibodies like anti-c or anti-K and Rhesus–anti D alone or may be accompanied by other Rh antibodies, examples anti-D with anti-C or anti-E. Clinical presentation of HDN varies from mild jaundice and anemia to hydrops fetalis (with ascites, pleural and pericardial effusions). This article discusses hemolytic due to incompability Rhesus anti-D.)
D-Dimer In Pregnancy Danny Ernest Jonas Luhulima; Batara Imanuel Sirait
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.696

Abstract

D-dimer is a fibrin degradation product that serves as a vital biomarker in the fibrinolytic system. This review aims to examine the role and mechanism of D-dimer during pregnancy and its measurement methods. The method used is a literature review of clinical studies and references related to hemostasis in pregnancy. Results show that pregnancy physiologically increases coagulation activity as a natural mechanism to prevent hemorrhage during delivery. Increased D-dimer levels are found in 27% of first-trimester pregnancies, 87% in the second trimester, and 100% in the third trimester. Pathological conditions such as preeclampsia, eclampsia, and venous thromboembolism (VTE) risks are closely linked to significant surges in D-dimer levels. While ELISA remains the gold standard for D-dimer testing, immunoturbidimetric and immunofiltration methods are more commonly used due to their speed and efficiency. In conclusion, although D-dimer levels naturally rise during pregnancy, monitoring this parameter is crucial for predicting medical emergencies like disseminated intravascular coagulation (DIC) to reduce maternal mortality rates.
Co-Authors Batara Imanuel Sirait Christian Ronald Tanggo Ria Amelia