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Rahwal, Sultan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media

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Xanthin Oxidase Activity of Acetone Extract from Cinnamomum burmannii (Nees & T. Nees) Blume. as an Antigout Agung, Yoki Permana; Rahwal, Sultan; Ramadani, Suci Indah; Ismed, Friadi; Arifa, Nurwahidatul
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 4: Jurnal Pembelajaran Dan Biologi Nukleus December 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i4.8502

Abstract

Background: Cinnamomum burmannii commonly referred to as Indonesian cinnamon, belongs to the Lauraceae family and is recognized for its substantial economic and pharmacological significance. The bark is predominantly utilized as it is enriched with bioactive constituents, including cinnamaldehyde, eugenol, and coumarin, which are known to exhibit antioxidant, antibacterial, antifungal, antidiabetic, and anti-inflammatory properties. In purine metabolism, xanthine oxidase (XO) functions as a key enzyme by facilitating the oxidation of hypoxanthine into xanthine and subsequently into uric acid. Elevated XO activity has been associated with increased uric acid levels, leading to conditions such as hyperuricemia and gout. Accordingly, this study was conducted to assess the inhibitory potential of the acetone extract of C. burmannii against xanthine oxidase activity. Methodology: Dried and authenticated bark samples were macerated using acetone as the extraction solvent. Xanthine oxidase inhibition was evaluated invitro using a UV–Vis spectrophotometric assay at 295 nm. Various extract concentrations (0.370–23.684 µg/mL) were tested under controlled conditions (pH 7.6, 25 °C, xanthine as the substrate). The IC₅₀ values were determined by linear regression analysis, and the relative inhibitory concentration (RIC₅₀) was calculated in comparison with allopurinol. Findings: The acetone extract of C. burmannii exhibited potent xanthine oxidase inhibitory activity with an IC₅₀ of 21.029 ppm (compared to allopurinol, IC₅₀ 2.7 ppm), demonstrating the potential of acetone as a solvent for extracting bioactive compounds, with a RIC₅₀ value of  0.13 indicating higher activity than previously reported ethanol extracts. Contribution: These findings indicate that acetone provides better selectivity in extracting compounds from C. burmannii, resulting in stronger xanthine oxidase inhibition. The acetone extract may serve as a promising natural alternative source for the development of antigout agents
Phytochemical Constituents of Cinnamomum burmannii (Ness & T.Nees) Blume: A Systematic Review Rahwal, Sultan; Agung, Yoki Permana; Ramadani, Suci Indah; Ismed, Friardi; Arifa, Nurwahidatul
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 4: Jurnal Pembelajaran Dan Biologi Nukleus December 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i4.8264

Abstract

Background: Cinnamomum burmannii is an Indonesian native cinnamon species with significant potential for developing pharmaceutical and functional food products. Methodology: This study aims to identify and analyze the phytochemical constituents of C. Burmannii through a systematic literature review using PRISMA databases such as PubMed, Scopus, and Science Direct,were searched from 2015-2025. Findings: The findings reveal that C. Burmannii contains diverse bioactive compounds, including aromatic aldehydes, phenolics, flavonoids, terpenoids, coumarins, aromatic alcohols, organic acids, and aromatic esters. Dominant compounds such as cinnamaldehyde, quercetin, catechin, and eugenol exhibit strong antimicrobial, antioxidant, antidiabetic, anti-inflammatory, and analgesic activities. Quantitative analysis shows total phenolic content ranging from 31–89 mg GAE/100 g, total flavonoid 15–80 mg QE/100 g, and total tannin 89–217 mg CE/g, with ethanol extraction yielding optimal results. Several novel pure compounds, including Burmanoside, Burmafuranic acid, Burmannic acid, and o-hydroxycinnamic acid, have been isolated and demonstrate antiproliferative and photoprotective activities. Contribution: This systematic review highlights the diversity of phytochemical constituents in C. Burmannii and emphasizes the influence of plants parts and extraction methods on phytochemicals profiles.
Co-Authors Agung, Yoki Permana Arifa, Nurwahidatul Friardi Ismed Ismed, Friadi Ramadani, Suci Indah