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All Journal JOPS (Journal Of Pharmacy and Science) Jurnal Pembelajaran dan Biologi Nukleus Narra J Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi GEMBIRA (Pengabdian Kepada Masyarakat)
Arifa, Nurwahidatul
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Chemical profiling of African leaves (Vernonia amygdalina Delile) and Kenikir leaves (Cosmos caudatus Kunth) extracts using Thin Layer Chromatography (TLC) Yesika, Relin; A, Meridha Mutiara; Arifa, Nurwahidatul; Ferdian, Arif; Andika, Miming; Rasyadi, Yahdian; Liana, Nana; Setiawati, Erdanela
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4103

Abstract

African leaves (Vernonia amygdalina Delile) and kenikir leaves (Cosmos caudatus Kunth) are plants that belong to the asteraceae family. Members of asteraceae have been used in food and medicine for centuries. This study aims to determine the secondary metabolite compounds contained in African leaves extracts and kenikir leaves through phytochemical screening using Thin-layer chromatography (TLC) method detected using UV 254nm and UV 366 nm light, as well as spot revealers that match the chemical group. The results of phytochemical screening using KLT show that African leaves contain flavonoids, terpenoids. And kenikir leaf extract is positive for steroids and flavonoids, one of them which is isocuesitrin.
Lichen substances from Teloschistes flavicans (Sw.) Norman: Isolation, crystal structure, and evaluation of their antibacterial activities Ismed, Friardi; Arifa, Nurwahidatul; Nissa, Mentari Q.; Putra, Deddi P.; Orue, Analia IC.; Clegg, Jack K.; Rouaud, Isabelle; Dévéhat, Françoise L.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1463

Abstract

Teloschistes flavicans (Sw.) Norman is a lichen known as the golden-haired lichen. This lichen has been recognized and used in herbal medicine mixtures as an antimicrobial and bioindicator of air pollution that plays a role in ecological systems. The aim of this study was to explore the potential of its secondary metabolites as antibacterial and anticancer agents, particularly against bacterial pneumonia. Two main compounds (vicacinin and parietin) were isolated with chromatography and identified by spectrometry and single-crystal X-ray diffraction. The crystallographic data of vicanicin are reported for the first time. Chromatography and recrystallization methods were used to obtain both compounds with orange (parietin) and white (vicanicin) crystals. Furthermore, these compounds were evaluated for cytotoxicity on keratinocytes (HaCaT) cells and antibacterial activity against pneumonia pathogens (Klebsiella pneumoniae ATCC 1706, Streptococcus pneumoniae ATCC 49619, Moraxella catarhalis ATCC 25240, and Staphylococcus pyogenes ATCC 19615). The cytotoxic activity of these compounds was moderate at the concentration of 50-100 µM. The antibacterial pneumonia activity was relatively weak compared to chloramphenicol. Between the two compounds, vicanicin showed stronger activity than parietin against all strains. Vicanicin was more active against Klebsiella pneumoniae and Staphylococcus pyogenes with minimum inhibitory concentrations of 156±0.77 µM and 156±0.91 µM, respectively. In this study, comprehensive molecular structures of parietin and vicanicin have been successfully elucidated, and their antibacterial and cytotoxic activities have been provided.
PENINGKATAN PENGETAHUAN SANTRI TENTANG PENGGUNAAN OBAT YANG RASIONAL MELALUI EDUKASI DAGUSIBU DI PESANTREN PROF. DR. HAMKA II PADANG Elvionita, Cindy; Ferilda, Siska; Marsellinda, Elsa; Andania, Meiridha Mutiara; Arifa, Nurwahidatul; Putra, Rama Feriska
Jurnal Gembira: Pengabdian Kepada Masyarakat Vol 3 No 04 (2025): AGUSTUS 2025
Publisher : Media Inovasi Pendidikan dan Publikasi

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Abstract

Penggunaan obat yang tidak rasional merupakan salah satu permasalahan kesehatan yang masih sering terjadi di masyarakat, termasuk di lingkungan pesantren. Santri yang menjalani kehidupan secara mandiri rentan melakukan swamedikasi tanpa pengetahuan yang memadai. Edukasi DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang) Obat dengan Benar merupakan salah satu pendekatan yang dapat digunakan untuk meningkatkan literasi penggunaan obat yang aman dan bertanggung jawab. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan santri kelas VII di Pondok Pesantren Prof. Dr. Hamka II Padang tentang penggunaan obat secara rasional melalui metode edukatif dan interaktif. Metode yang digunakan meliputi pemaparan materi, kuis interaktif, sesi tanya jawab, dan diskusi kasus sederhana. Hasil pelaksanaan menunjukkan tingginya partisipasi dan antusiasme santri, serta peningkatan pemahaman terkait klasifikasi obat, cara penyimpanan yang tepat, dan pentingnya membaca informasi pada kemasan obat. Edukasi ini juga mendorong terjadinya perubahan perilaku awal pada peserta, seperti keinginan untuk menyebarkan informasi yang diperoleh kepada teman sebaya. Kegiatan ini membuktikan bahwa pendekatan edukatif berbasis komunitas pesantren efektif dalam meningkatkan kesadaran dan pengetahuan remaja tentang penggunaan obat yang benar. Intervensi semacam ini diharapkan dapat direplikasi di pesantren lain sebagai upaya promotif dalam penguatan literasi kesehatan di kalangan remaja.
Pelatihan Identifikasi Cepat Fitokimia pada Mahasiswa STIFI BP Palembang Ferdian, Arif; Arifa, Nurwahidatul; Bakhtiar, Amri
ABDIKAN: Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi Vol. 2 No. 4 (2023): November 2023
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/abdikan.v2i4.2372

Abstract

Identification of phytochemicals is an important preliminary test that pharmacy students need to know and understand. As is known, that natural ingredients are an important aspect that plays a role in herbal medicine. One of the most prominent uses of plants is as a medicinal ingredient. In determining the traditional use of natural materials, it is necessary to know which groups of chemical compounds are contained in natural materials. Chemical compounds contained in natural products are grouped into alkaloids, phenolics, flavonoids, saponins, steroids and terpenoids. To determine the class of compounds in natural products, it is necessary to carry out preliminary tests quickly, namely by testing phytochemicals. Phytochemical identification training is aimed at STIFI Bhakti Pertiwi Palembang students who conduct field studies at Anai Land, Padang Pariaman Regency, Padang, West Sumatra. This field study activity is held as a support for natural product chemistry lectures. Phytochemical testing was carried out in groups guided by each. Students who have received training can carry out phytochemical testing of natural ingredients as a provision for final project research.
Xanthin Oxidase Activity of Acetone Extract from Cinnamomum burmannii (Nees & T. Nees) Blume. as an Antigout Agung, Yoki Permana; Rahwal, Sultan; Ramadani, Suci Indah; Ismed, Friadi; Arifa, Nurwahidatul
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 4: Jurnal Pembelajaran Dan Biologi Nukleus December 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i4.8502

Abstract

Background: Cinnamomum burmannii commonly referred to as Indonesian cinnamon, belongs to the Lauraceae family and is recognized for its substantial economic and pharmacological significance. The bark is predominantly utilized as it is enriched with bioactive constituents, including cinnamaldehyde, eugenol, and coumarin, which are known to exhibit antioxidant, antibacterial, antifungal, antidiabetic, and anti-inflammatory properties. In purine metabolism, xanthine oxidase (XO) functions as a key enzyme by facilitating the oxidation of hypoxanthine into xanthine and subsequently into uric acid. Elevated XO activity has been associated with increased uric acid levels, leading to conditions such as hyperuricemia and gout. Accordingly, this study was conducted to assess the inhibitory potential of the acetone extract of C. burmannii against xanthine oxidase activity. Methodology: Dried and authenticated bark samples were macerated using acetone as the extraction solvent. Xanthine oxidase inhibition was evaluated invitro using a UV–Vis spectrophotometric assay at 295 nm. Various extract concentrations (0.370–23.684 µg/mL) were tested under controlled conditions (pH 7.6, 25 °C, xanthine as the substrate). The IC₅₀ values were determined by linear regression analysis, and the relative inhibitory concentration (RIC₅₀) was calculated in comparison with allopurinol. Findings: The acetone extract of C. burmannii exhibited potent xanthine oxidase inhibitory activity with an IC₅₀ of 21.029 ppm (compared to allopurinol, IC₅₀ 2.7 ppm), demonstrating the potential of acetone as a solvent for extracting bioactive compounds, with a RIC₅₀ value of  0.13 indicating higher activity than previously reported ethanol extracts. Contribution: These findings indicate that acetone provides better selectivity in extracting compounds from C. burmannii, resulting in stronger xanthine oxidase inhibition. The acetone extract may serve as a promising natural alternative source for the development of antigout agents
Phytochemical Constituents of Cinnamomum burmannii (Ness & T.Nees) Blume: A Systematic Review Rahwal, Sultan; Agung, Yoki Permana; Ramadani, Suci Indah; Ismed, Friardi; Arifa, Nurwahidatul
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 4: Jurnal Pembelajaran Dan Biologi Nukleus December 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i4.8264

Abstract

Background: Cinnamomum burmannii is an Indonesian native cinnamon species with significant potential for developing pharmaceutical and functional food products. Methodology: This study aims to identify and analyze the phytochemical constituents of C. Burmannii through a systematic literature review using PRISMA databases such as PubMed, Scopus, and Science Direct,were searched from 2015-2025. Findings: The findings reveal that C. Burmannii contains diverse bioactive compounds, including aromatic aldehydes, phenolics, flavonoids, terpenoids, coumarins, aromatic alcohols, organic acids, and aromatic esters. Dominant compounds such as cinnamaldehyde, quercetin, catechin, and eugenol exhibit strong antimicrobial, antioxidant, antidiabetic, anti-inflammatory, and analgesic activities. Quantitative analysis shows total phenolic content ranging from 31–89 mg GAE/100 g, total flavonoid 15–80 mg QE/100 g, and total tannin 89–217 mg CE/g, with ethanol extraction yielding optimal results. Several novel pure compounds, including Burmanoside, Burmafuranic acid, Burmannic acid, and o-hydroxycinnamic acid, have been isolated and demonstrate antiproliferative and photoprotective activities. Contribution: This systematic review highlights the diversity of phytochemical constituents in C. Burmannii and emphasizes the influence of plants parts and extraction methods on phytochemicals profiles.
Co-Authors A, Meridha Mutiara Agung, Yoki Permana Amri Bakhtiar Clegg, Jack K. Dévéhat, Françoise L. Elsa Marsellinda Elvionita, Cindy Ferdian, Arif Friardi Ismed Ismed, Friadi liana, nana Meiridha Mutiara Andania Miming Andika Nissa, Mentari Q. Orue, Analia IC. Putra, Deddi P. Putra, Rama Feriska Rahwal, Sultan Ramadani, Suci Indah Rouaud, Isabelle Setiawati, Erdanela Siska Ferilda Yahdian Rasyadi Yesika, Relin