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All Journal JOPS (Journal Of Pharmacy and Science) Narra J GEMBIRA (Pengabdian Kepada Masyarakat)
Arifa, Nurwahidatul
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Religion Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Chemical profiling of African leaves (Vernonia amygdalina Delile) and Kenikir leaves (Cosmos caudatus Kunth) extracts using Thin Layer Chromatography (TLC) Yesika, Relin; A, Meridha Mutiara; Arifa, Nurwahidatul; Ferdian, Arif; Andika, Miming; Rasyadi, Yahdian; Liana, Nana; Setiawati, Erdanela
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4103

Abstract

African leaves (Vernonia amygdalina Delile) and kenikir leaves (Cosmos caudatus Kunth) are plants that belong to the asteraceae family. Members of asteraceae have been used in food and medicine for centuries. This study aims to determine the secondary metabolite compounds contained in African leaves extracts and kenikir leaves through phytochemical screening using Thin-layer chromatography (TLC) method detected using UV 254nm and UV 366 nm light, as well as spot revealers that match the chemical group. The results of phytochemical screening using KLT show that African leaves contain flavonoids, terpenoids. And kenikir leaf extract is positive for steroids and flavonoids, one of them which is isocuesitrin.
Lichen substances from Teloschistes flavicans (Sw.) Norman: Isolation, crystal structure, and evaluation of their antibacterial activities Ismed, Friardi; Arifa, Nurwahidatul; Nissa, Mentari Q.; Putra, Deddi P.; Orue, Analia IC.; Clegg, Jack K.; Rouaud, Isabelle; Dévéhat, Françoise L.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1463

Abstract

Teloschistes flavicans (Sw.) Norman is a lichen known as the golden-haired lichen. This lichen has been recognized and used in herbal medicine mixtures as an antimicrobial and bioindicator of air pollution that plays a role in ecological systems. The aim of this study was to explore the potential of its secondary metabolites as antibacterial and anticancer agents, particularly against bacterial pneumonia. Two main compounds (vicacinin and parietin) were isolated with chromatography and identified by spectrometry and single-crystal X-ray diffraction. The crystallographic data of vicanicin are reported for the first time. Chromatography and recrystallization methods were used to obtain both compounds with orange (parietin) and white (vicanicin) crystals. Furthermore, these compounds were evaluated for cytotoxicity on keratinocytes (HaCaT) cells and antibacterial activity against pneumonia pathogens (Klebsiella pneumoniae ATCC 1706, Streptococcus pneumoniae ATCC 49619, Moraxella catarhalis ATCC 25240, and Staphylococcus pyogenes ATCC 19615). The cytotoxic activity of these compounds was moderate at the concentration of 50-100 µM. The antibacterial pneumonia activity was relatively weak compared to chloramphenicol. Between the two compounds, vicanicin showed stronger activity than parietin against all strains. Vicanicin was more active against Klebsiella pneumoniae and Staphylococcus pyogenes with minimum inhibitory concentrations of 156±0.77 µM and 156±0.91 µM, respectively. In this study, comprehensive molecular structures of parietin and vicanicin have been successfully elucidated, and their antibacterial and cytotoxic activities have been provided.
PENINGKATAN PENGETAHUAN SANTRI TENTANG PENGGUNAAN OBAT YANG RASIONAL MELALUI EDUKASI DAGUSIBU DI PESANTREN PROF. DR. HAMKA II PADANG Elvionita, Cindy; Ferilda, Siska; Marsellinda, Elsa; Andania, Meiridha Mutiara; Arifa, Nurwahidatul; Putra, Rama Feriska
Jurnal Gembira: Pengabdian Kepada Masyarakat Vol 3 No 04 (2025): AGUSTUS 2025
Publisher : Media Inovasi Pendidikan dan Publikasi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penggunaan obat yang tidak rasional merupakan salah satu permasalahan kesehatan yang masih sering terjadi di masyarakat, termasuk di lingkungan pesantren. Santri yang menjalani kehidupan secara mandiri rentan melakukan swamedikasi tanpa pengetahuan yang memadai. Edukasi DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang) Obat dengan Benar merupakan salah satu pendekatan yang dapat digunakan untuk meningkatkan literasi penggunaan obat yang aman dan bertanggung jawab. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan santri kelas VII di Pondok Pesantren Prof. Dr. Hamka II Padang tentang penggunaan obat secara rasional melalui metode edukatif dan interaktif. Metode yang digunakan meliputi pemaparan materi, kuis interaktif, sesi tanya jawab, dan diskusi kasus sederhana. Hasil pelaksanaan menunjukkan tingginya partisipasi dan antusiasme santri, serta peningkatan pemahaman terkait klasifikasi obat, cara penyimpanan yang tepat, dan pentingnya membaca informasi pada kemasan obat. Edukasi ini juga mendorong terjadinya perubahan perilaku awal pada peserta, seperti keinginan untuk menyebarkan informasi yang diperoleh kepada teman sebaya. Kegiatan ini membuktikan bahwa pendekatan edukatif berbasis komunitas pesantren efektif dalam meningkatkan kesadaran dan pengetahuan remaja tentang penggunaan obat yang benar. Intervensi semacam ini diharapkan dapat direplikasi di pesantren lain sebagai upaya promotif dalam penguatan literasi kesehatan di kalangan remaja.
Co-Authors A, Meridha Mutiara Andika, Miming Clegg, Jack K. Dévéhat, Françoise L. Elsa Marsellinda Elvionita, Cindy Ferdian, Arif Friardi Ismed liana, nana Meiridha Mutiara Andania Nissa, Mentari Q. Orue, Analia IC. Putra, Deddi P. Putra, Rama Feriska Rouaud, Isabelle Setiawati, Erdanela Siska Ferilda Yahdian Rasyadi Yesika, Relin