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All Journal Denta: Jurnal Kedokteran Gigi
Soemartono
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Dentistry

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Pengaruh Pemberian Ibuprofen Preoperatif Terhadap Kepadatan Serabut Kolagen Pada Proses Penyembuhan Luka Pasca Ekstraksi Noer Avila Firdauzi; Soemartono; Monika Elidasari
Denta Journal Kedokteran Gigi Vol 10 No 2 (2016): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Socket healing after extraction have two phases the healing of soft tissue and hard tissue. Ibuprofen is one of the NSAID that act as well as analgesics and antiinflammatory drugs. Ibuprofen is generally used in dental clinics after extraction to relieveof pain after tooth extraction. Preoperative Ibuprofen take effect of density of collagen fibers in the proliferative phase. The formation of collagen fibers in the socket healing process is important to support the strength of the tissue. The collagen is initiated healing of soft tissue and begin process of bone healing. Purpose: The purpose of this research was to know the influence of preoperative Ibuprofen related to density of collagen fibers on the socket healing process after extraction. Materials and Methods: This research is true experimental laboratorium. The subjects of this research were 20 Wistar rats which are divided into a control group (K) and treatment group (X). The treatment group was given preoperative Ibuprofen 1 hour before the tooth extraction and the control group were given only 0.2% NaCMC. The Wistar rats were decapitated on day 7 and then the appearance of collagen density is seen histologically. The results were analyzed with statistical methods Mann Whitney test. Results: The results showed a significant difference between control group and treatment group (p <0.05). Conclusion: The preoperative Ibuprofen give less of collagen density on socket healing process after tooth extraction.
Perbedaan Kitosan Berat Molekul Rendah dan Tinggi Terhadap Jumlah Sel Limfosit pada Proses Penyembuhan Luka Pencabutan Gigi Felinda Gunawan; Sularsih; Soemartono
Denta Journal Kedokteran Gigi Vol 9 No 1 (2015): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Molecular weight is one of the chitosan characteristic that affects the effectiveness application for wound healing of dental extraction. Chitosan could improve wound healing process because of its anti inflammation property and improve proliferation phase. Lymphocyte cell is one of the main cells that act during inflammatory phase. Purpose: the aim of this experiment is to account lymphocyte cell in wound healing of dental extraction using chitosan with different molecular weight. Materials and Methods: 54 Male Rattus Norvegicus were divided into 3 groups. Group I is control group (without chitosan). Group IIwas given low molecular weight chitosan. Group III was given high molecular weight chitosan. Rats were sacrificed by decapitation on day 5 and day 7 post extraction then they were examined histopatologically to see the change in lymphocyte cell number. Result: Data were statistically analyzed with One Way ANOVA and LSD with degree of significant p< 0,05 showed significant difference between high molecular weight chitosan group and low molecular weight chitosan group after 5 and 7 days observation. Conclusion: High molecular weight chitosan was found more effective to decrease lymphocyte cell amounts more than low molecular weight chitosan in wound healing of dental extraction process.
Co-Authors Felinda Gunawan Monika Elidasari Noer Avila Firdauzi Sularsih