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All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Shalsabillah, Nadia Fitri
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Survival Pasien Kanker Kolorektal di RSUD Nganjuk dan Ekspresi Gen APC, KRAS dan SMAD4 Pada Tumornya Hernanda, Pratika Yuhyi; Pramugyono, Pramugyono; Wulandari, Ida Septika; Agusaputra, Harman; Sugeng, Maria Wijayanti; Ama, Fuad; Shalsabillah, Nadia Fitri
Majalah Kedokteran Indonesia Vol 75 No 5 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.5-2025-1830

Abstract

Introduction: The survival of colorectal cancer patients is significantly influenced by comorbid factors, including age, smoking, obesity, comorbidities, and genetics. The purpose of this study was to analyze factors affecting colorectal cancer survival in Nganjuk Regional General Hospital and to examine the expression of the APC, KRAS, and SMAD4 genes in tumor tissue.Methods: We analyzed the comorbid factors in 51 colorectal cancer patients and then analyzed their relationship to colorectal cancer survival. Immunohistochemistry (IHC) staining was performed to examine the expression of the KRAS, APC, and SMAD4 genes in colorectal cancer tissue. Data were analyzed using bivariate analysis between variables using the Chi-square test, and survival analysis was performed using Kaplan-Meier statistical analysis.Results: The data shows that colorectal cancer patients with comorbidities tend to have a lower survival rate than those without comorbidities (P-value 0.054), and patients with metastases also have a lower survival rate (P-value 0.748). APC and SMAD4 gene expression in stromal tissue IHC was more dominant than KRAS gene expression in the stroma. Increased gene expression in the stroma indicates its role in tumor invasion and metastasis.Conclusion: Comorbidities and the presence of metastases negatively impact the survival rate of colorectal cancer patients. APC and SMAD4 gene expression in the stromal tissue was more dominant than KRAS gene expression in the stroma, suggesting a role for these genes in tumor invasion and metastasis.
Co-Authors Ama, Fuad HARMAN AGUSAPUTRA Pramugyono, Pramugyono Pratika Yuhyi Hernanda Sugeng, Maria Wijayanti Wulandari, Ida Septika