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All Journal Biota Jurnal Veteriner
Haniyyah, Hernanda Afra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Medicine & Pharmacology Veterinary

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Phylogenetic relationship of plastid large single copy genome and potential of ginsenoside compounds from Panax in Alzheimer disease Kinasih, Anggiresti; Ahmar, Rasyidah Fauzia; Fatmawati, Dwi Retno; Rivaldi, Muhammad; Suhaemi, Emi; Saputra, Novanda Eka; Haniyyah, Hernanda Afra
Biota Vol 18 No 1 (2025)
Publisher : Universitas Islam Negeri Mataram

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Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most prevalent cause of dementia, marked by cognitive decline and memory loss. Current treatments are largely symptomatic and do not halt disease progression, underscoring the urgent need for novel therapeutics. Natural products, such as Panax notoginseng, offer promising alternatives due to their structural diversity and multi-target potential. This study investigates the therapeutic potential of 125 terpenoid compounds identified from P. notoginseng, focusing on their relevance to AD. Eight ginsenosides demonstrated notable neuroprotective effects, including improvements in memory and cognitive function. Among them, Ginsenoside Rb1 and Notoginsenoside R1 exhibited low predicted toxicity via oral and intraperitoneal routes, indicating favorable safety profiles. Target prediction and molecular docking suggest these compounds interact with G protein-coupled receptors implicated in cognition and neuroprotection, such as dopaminergic, serotonergic, muscarinic, and adrenergic receptors. However, their deviation from Lipinski’s Rule of Five may limit oral bioavailability. To address this, nanotechnology-based delivery systems are proposed to enhance solubility, permeability, and drug-likeness. These findings support the continued exploration of P. notoginseng ginsenosides as potential anti-dementia agents and highlight nanotechnology's role in overcoming pharmacokinetic limitations
Histomorfometri Duodenum Tikus Putih (Rattus norvegicus) Betina setelah Pemberian Polyethylene-terephthalate (PET) dalam Bentuk Mikroplastik Fitriedis, Dyana Destrianingsih; Sitasiwi, Agung Janika; Haniyyah, Hernanda Afra
Jurnal Veteriner Vol. 27 No. 1 (2026)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/

Abstract

Mikroplastik merupakan partikel plastik berukuran kurang dari 5 mm yang bersifat persisten, toksik dan berpotensi menimbulkan efek biologis terhadap organisme. Salah satu jenis mikroplastik yang umum ditemukan di lingkungan adalah Polietilena Tereftalat (Polyethylene-terephthalate) (PET). Polietilena Tereftalat merupakan plastik yang banyak digunakan dalam industri makanan, tetapi efek terhadap histomorfometri usus halus khususnya duodenum belum banyak dilaporkan. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian mikroplastik PET terhadap histomorfometri duodenum tikus putih. Penelitian menggunakan desain Rancangan Acak Lengkap (RAL), menggunakan 20 ekor tikus betina galur Wistar yang dibagi menjadi empat kelompok perlakuan dengan lima ulangan. Kelompok perlakuan meliputi kontrol (P0) diberi air minum 2 mL, perlakuan P1 diberi mikroplastik PET dengan dosis 0,005 mg/2 mL/hari, perlakuan P2 diberi mikroplastik PET dengan dosis 0,05 mg/2 mL/hari, perlakuan P3 diberi mikroplastik PET dengan dosis 0,25 mg/2 mL/hari. Peubah yang diamati adalah diameter duodenum, tebal lapisan muskularis, panjang vili dan struktur epitel villi duodenum. Data hasil penelitian dianalisis menggunakan uji sidik ragam dengan lanjutan uji jarak berganda Duncan antar perlakuan yang berbeda nyata. Hasil penelitian menunjukkan bahwa pemberian mikroplastik PET tidak berpengaruh nyata terhadap diameter duodenum antar perlakuan (P>0.05), namun berbeda nyata terhadap tebal lapisan muskularis dan panjang villi (P<0.05). Pemberian mikroplastik PET juga memberikan pengaruh pada struktur epitel vili duodenum. Simpulan dari penelitian ini adalah pemberian mikroplastik PET berpotensi menyebabkan gangguan sistem  pencernaan yang ditunjukkan dengan perubahan tebal lapisan muskularis eksterna dan panjang vili, serta kerusakan struktur epitel penyusun vili duodenum.
Co-Authors Agung Janika Sitasiwi Ahmar, Rasyidah Fauzia Fatmawati, Dwi Retno Fitriedis, Dyana Destrianingsih Kinasih, Anggiresti Rivaldi, Muhammad Saputra, Novanda Eka Suhaemi, Emi