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All Journal Biosaintifika: Journal of Biology & Biology Education Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) Biota
Ahmar, Rasyidah Fauzia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Medicine & Pharmacology Public Health

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Potential of Red Okra Extract (Abelmoschus esculentus L. Moench) to Restore Kidney Damage due to Sodium Nitrite Wahyuningsih, Sri Puji Astuti; Fachrisa, Amalia; Nisa’, Nabilatun; Kusuma, Baskara Wiku Adi; Shoukat, Nadia; Ahmar, Rasyidah Fauzia; Alifiyah, Na'ilah Insani
Biosaintifika: Journal of Biology & Biology Education Vol 13, No 1 (2021): April 2021
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v13i1.28141

Abstract

Sodium nitrite (NaNO2) found in vegetables, drinking water, and cured meats, can damage tissue because it is an oxidant. Plant phytochemicals such as quercetin are antioxidants. This study aimed to determine the potential of red okra pods ethanol extract (ROE) to repair kidney damage in mice (Mus musculus) induced by NaNO2. The red okra pods were extracted three times with saturated ethanol. The experiment used 36 male BALB/c mice aged 6-8 weeks and body weight of about 28 g. There are six research groups, namely, normal control, negative control (exposure to NaNO2 50 mg/kg BW), treatment of exposure to NaNO2 and administration of ROE at doses of 25, 50, 75, and 100 mg/kg BW. Sodium nitrite and ROE were given daily for 23 days by gavage. On day 24, the serum was isolated. Blood urea nitrogen (BUN) and creatinine (Cre) levels are measured to assess kidney function, as well as measuring the oxidant malondialdehyde (MDA) and the antioxidant enzyme of superoxide dismutase (SOD). The kidneys were made histological preparations and analyzed on the proximal convoluted tubule (PCT).  All data were statistically analyzed (α=0.05). This study indicated that the administration of ROE at a 100 mg/kg BW dose is the most optimal in repairing damage to the PCT with increased normal cells and reduced necrosis. Besides, it degraded BUN, Cre, and MDA levels in the serum of mice exposed to NaNO2 compared to the other treatments. All doses of ROE promoted the SOD level. ROE restore kidney tissue, especially on PCT to normal. Kidney damage due to exposure to NaNO2 preservatives can be reduced by administering ROE. ROE prevents kidney damage through an increase in antioxidant enzymes. ROE can be used as a food ingredient as a source of antioxidants, thereby reducing the impact of oxidant compounds.
Dampak Inklusi In-ovo Feeding Vitamin E dan Selenium pada Histomorfometri Bursa Embrio Itik Hibrida Ahmar, Rasyidah Fauzia; Hanum, Qanza Sofia; Kasiyati, Kasiyati
Buletin Anatomi dan Fisiologi Volume 10, Nomor 2, Tahun 2025
Publisher : Departemen Biologi Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/baf.10.2.2025.144-152

Abstract

Vitamin E dan selenium adalah dua nutrisi penting yang berperan dalam menjaga kesehatan tubuh serta mendukung fungsi vital organ. Peran vitamin E (VE) dan selenium (Se) sebagai antioksidan dapat dimanfaatkan untuk meningkatkan performa penetasan itik. Penelitian ini bertujuan untuk menganalisis struktur histologi bursa fabricius embrio itik setelah inklusi in-ovo vitamin E dan selenium. Penelitian ini menggunakan rancangan acak lengkap (RAL) yang terdiri atas empat perlakuan, yaitu K0 (kontrol), K1 (inklusi in-ovo 0,1 mL NaCl 0,89%), K2 (inklusi in-ovo 0,1 mL VE dan Se), dan K3 (inklusi in-ovo 0,15 mL VE dan Se). Perlakuan diberikan pada saat telur tetas berumur 14 hari, inkubasi diakhiri pada hari ke-26. Pembuatan preparat bursa menggunakan metode paraffin dan pewarnaan hematoksilin eosin. Parameter yang diamati berupa jumlah dan diameter plika, jumlah dan diameter folikel, tebal epitelium, diameter lumen, tebal korteks dan medula. Data diuji dan dianalisis dengan Analysis of Varians (ANOVA) pada taraf signifikansi 5% (α = 0,05) dan Kruskal-Wallis. Hasil menunjukkan adanya perbedaan nyata (P<0,05) pada jumlah dan diameter folikel. Jumlah plika, diameter plika, tebal epitelium, diameter lumen, tebal korteks dan tebal medula menunjukkan hasil berbeda tidak nyata (P>0,05). Berdasarkan hasil penelitian disimpulkan bahwa injeksi vitamin E dan selenium secara in-ovo berpotensi mengoptimalkan perkembangan struktur histologi folikel bursa fabricius, pada gilirannya mendukung kerja sistem imun itik hibrida. Vitamin E and selenium are two important nutrients that play a role in maintaining body health and supporting vital organ function. The role of vitamin E (VE) and selenium (Se) as antioxidants can be utilized to improve duck hatchability. This study aims to analyze the histological structure of the bursa fabricius of duck embryos after in-ovo inclusion of vitamin E and selenium. This study used a completely randomized design (CRD) consisting of four treatments, namely K0 (control), K1 (in-ovo inclusion of 0.1 mL of 0.89% NaCl), K2 (in-ovo inclusion of 0.1 mL of VE and Se), and K3 (in-ovo inclusion of 0.15 mL of VE and Se). The treatments were administered when the eggs were 14 days old; egg incubation ended on day 26. Bursa preparations were made using the paraffin method and stained with hematoxylin-eosin. The parameters observed were the number and diameter of plicae, the number and diameter of follicles, the thickness of the epithelium, the diameter of the lumen, and the thickness of the cortex and medulla. The data were analyzed using Analysis of Variance (ANOVA) at a significance level of 5% (α = 0.05) and the Kruskal-Wallis test. The results showed a significant difference (P<0.05) in the number and diameter of follicles. The number and diameter of plicae,  epithelium thickness, lumen diameter, cortex and medulla thickness showed no significant differences (P>0.05). Based on the results of this study, it can be concluded that in-ovo injection of VE and Se has the potential to optimize the histological structure of the bursa fabricius follicles, which in turn supports the immune system of hybrid ducks.
Phylogenetic relationship of plastid large single copy genome and potential of ginsenoside compounds from Panax in Alzheimer disease Kinasih, Anggiresti; Ahmar, Rasyidah Fauzia; Fatmawati, Dwi Retno; Rivaldi, Muhammad; Suhaemi, Emi; Saputra, Novanda Eka; Haniyyah, Hernanda Afra
Biota Vol 18 No 1 (2025)
Publisher : Universitas Islam Negeri Mataram

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Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most prevalent cause of dementia, marked by cognitive decline and memory loss. Current treatments are largely symptomatic and do not halt disease progression, underscoring the urgent need for novel therapeutics. Natural products, such as Panax notoginseng, offer promising alternatives due to their structural diversity and multi-target potential. This study investigates the therapeutic potential of 125 terpenoid compounds identified from P. notoginseng, focusing on their relevance to AD. Eight ginsenosides demonstrated notable neuroprotective effects, including improvements in memory and cognitive function. Among them, Ginsenoside Rb1 and Notoginsenoside R1 exhibited low predicted toxicity via oral and intraperitoneal routes, indicating favorable safety profiles. Target prediction and molecular docking suggest these compounds interact with G protein-coupled receptors implicated in cognition and neuroprotection, such as dopaminergic, serotonergic, muscarinic, and adrenergic receptors. However, their deviation from Lipinski’s Rule of Five may limit oral bioavailability. To address this, nanotechnology-based delivery systems are proposed to enhance solubility, permeability, and drug-likeness. These findings support the continued exploration of P. notoginseng ginsenosides as potential anti-dementia agents and highlight nanotechnology's role in overcoming pharmacokinetic limitations
Co-Authors Alifiyah, Na'ilah Insani Fachrisa, Amalia Fatmawati, Dwi Retno Haniyyah, Hernanda Afra Hanum, Qanza Sofia Kasiyati Kasiati Kinasih, Anggiresti Kusuma, Baskara Wiku Adi Nisa’, Nabilatun Rivaldi, Muhammad Saputra, Novanda Eka Shoukat, Nadia Sri Puji Astuti Wahyuningsih, Sri Puji Astuti Suhaemi, Emi